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James Vaughn KohlJames Vaughn Kohl
James Vaughn Kohl was the first to help accurately conceptualize energy-dependent RNA-mediated cell type differentiation via the pheromone-controlled physiology of reproduction, and he began presenting his findings to the scientific community in 1992. He continues to disseminate accurate information to diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualizations and model of energy-dependent biophysically constrained biologically-based cause and effect. Kohl has integrated experimental evidence that pinpoints the de novo creation of an ecologically adapted neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain. Ecological variation is linked to ecological adaptations via the sensory integration of olfactory and visual input, which determines how behavioral development leads to the development of personal preferences for food and for other people. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by distinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Additional published works have continued to link what is currently known about nutritional epigenetics, food odors, and human pheromones, which link conserved molecular mechanisms  from ecological variation to RNA-mediated cell type differentiation and ecological adaptions in species from microbes to man.

Credentials

Kohl worked as a medical laboratory scientist from 1974 until 2013, and he devoted more than twenty-nine of those thirty-nine years to researching the relationship between the sense of smell and cell type differentiation, which he linked to life history transitions that include the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. That fact led Kohl to recognize how nutrient-dependent pheromone-controlled cell type differentiation enables ecological variation to epigenetically effected cell type differentiation in all cells of all tissues in all organs of all organ systems in all organisms via conserved molecular mechanisms.

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James V. Kohl is a member of:

Kohl is a former member or will become a former member of:

* Asterisks indicate approximately how many times Kohl has presented at an annual meeting. Other publications:

Kohl, J.V. (2013) Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Socioaffective Neuroscience & Psychology, 3: 20553.

Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.

Diamond M, Binstock T, Kohl JV. From fertilization to adult sexual behavior. Horm Behav. 1996 Dec;30(4):333-53. (Authors’ copy here.)

Unpublished (invited review of nutritional epigenetics for the journal Nutrients)

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

Selected Presentations:

Nutrient-dependent / Pheromone-controlled adaptive evolution: (a mammalian model of thermodynamics and organism-level thermoregulation) 5.5 minute video presentation

See also: Nutrient-dependent/pheromone-controlled adaptive evolution

Human Pheromones: Epigenetic Effects of Odors and Their Affects on Behavior

Human pheromones, epigenetics, physiology, and the development of animal behavior

Human Pheromones: The Mind’s Eyes and behavior (videos from my 2010 presentation to Mensa)

Adaptations

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Claims that “…mutations supply the raw material from which new life forms evolve…” continue to be replaces as experimental evidence shows that “Ecological variation is the raw material by which natural selection can drive evolutionary divergence [1–4].”

Links: www.ncbi.nlm.nih.gov, rspb.royalsocietypublishing.org

Alternative Splicings

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“Alternative splicing (AS) is one of the key processes involved in the regulation of gene expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the joining of selected exons, thus ensuring the correct processing of the primary transcript into the mature mRNA. The combinatorial nature of AS allows a great expansion of the genome coding potential, as multiple splice-variants encoding for different proteins may arise from a single gene.”

Links: www.ncbi.nlm.nih.gov

Diseases & Disorders

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Comparative approaches in evolutionary psychology: molecular neuroscience meets the mind won the same award in 2002. Excerpt: “Evolutionary psychologists often overlook a wealth of information existing between the proximate genotypic level and the ultimate phenotypic level. This commonly ignored level of biological organization is the ongoing activity of neurobiological systems.”

Links: www.ncbi.nlm.nih.gov

Ecology

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In 2014, Israeli middle schools began to teach the theory of evolution. “…learning about evolution is not the primary function of the decision, but rather to use it as a building block for students to learn more about their ecology.” Serious scientists throughout the world have been learning the difference between theory and biologically-based facts during the past decade. Some think it is time to teach facts before students begin to believe in ridiculous theories.

Links: www.educationnews.org

Human Brain

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The development of the central nervous system is nutrient-dependent and pheromone-controlled. It can be viewed in the context of differences in nutrient-dependent microRNAs MicroRNA Expression and Regulation in Human, Chimpanzee, and Macaque Brains. It can also be viewed in the context of differences in amino acid substitutions in primates. the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla. — Dobzhansky

Links: www.dx.doi.org, www.jstor.org

Human Pheromones

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The epigenetic effect of human pheromones on the development of RNA-mediated changes in morphology and behavior parallel the effects on morphology and affects on behavior in the honeybee. See our award-winning review: Human pheromones: integrating neuroendocrinology and ethology

Links: www.nel.edu

Light Energy

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Light-induced amino acid substitutions link the biophysically constrained chemistry of RNA-mediated protein folding from the biological energy of the sun to cell type differentiation in plants and animals. Unfortunately, some researchers do not know the difference between a mutation and an amino acid substitution.

Links: www.pnas.org

Model Organisms

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Model organisms link top-down causation to epigenetically-effected differences in morphology and behavior. For example, the honeybee is a model organism for studying human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, diseases of the X chromosome, learning and memory, as well as conditioned responses to sensory stimuli. See: Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors.

Links: www.ncbi.nlm.nih.gov

Neuronal Plasticity

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Amino acid substitutions are linked from metabolic networks and genetic networks to human behavior during life history transitions. See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

Links: www.dx.doi.org

Nutrigenomics

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Nutrient-dependent alternative splicings link what is currently known about nutrigenomics to metabolic networks and genetic networks. See: Nutrigenomics: A controversy on Science Direct (below)

Links: www.sciencedirect.com

Pharmacogenomics

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Metabolic networks and genetic networks are linked from the metabolism of therapeutic drugs to epigenetically effected amino acid substitutions and RNA-mediated outcomes. See: Clinically Actionable Genotypes Among 10,000 Patients With Preemptive Pharmacogenomic Testing

Links: www.medscape.com

Physics

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“The absorption of quanta of light (photons) is important for many biological processes such as vision, photosynthesis, and animal magnetoreception…” Photoactivated biological processes as quantum measurements. “Analyzing photosynthesis, vision, and magnetoreception, they concluded that only the latter requires quantum coherence. For the other two, the ensuing chemical reactions may still occur without it, albeit with reduced efficiency.” Synopsis: When is Biology Quantum? The fact that biophysical constraints prevent mutations from leading to increasing organismal complexity has been virtually ignored by population geneticists. An extreme example of this ignorance is manifested in the conclusion from Mutation-Driven Evolution (p. 199). “… genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world.” Population geneticist ignore the need for anti-entropic epigenetic traps that link entropic elasticity to epistasis.

Links: www.link.aps.org, physics.aps.org, www.amazon.com/books

RNA Directed

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RNA-directed DNA methylation links RNA-mediated alternative splicings to nutrient-dependent cell type differentiation. See: RNA-directed DNA methylation: an epigenetic pathway of increasing complexity

Links: dx.doi.org

Variations

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Ecological variation is linked to ecological adaptations by differences in viral microRNAs and nutrient-dependent microRNAs. The nutrient-dependent microRNA/messenger RNA balance links the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man via the physiology of their pheromone-controlled reproduction and fixation of amino acid substitutions.


I performed diagnostic testing on people during a 4 decades-long career as a medical laboratory scientist. That experience makes me uniquely qualified to integrate information from the fields of ecology, biophysics, chemistry, microbiology, epigenetics, molecular biology, neuroscience, and animal behavior. Here, I explore the relevance of different scientific disciplines to the organization and activation of “The Mind’s Eyes” in the context of informed scientific views that link differences in the body to differences in behavior. Nearly everything known about cell type differences in species from microbes to man has been learned since the turn of this century. We predicted most of what has been learned about the molecular epigenetics of cell type differentiation in our 1996 review: From Fertilization to Adult Sexual Behavior. My other published works, presentations, and this blog continues to explore that paradigm-shifting work and show how ecological variation leads to ecological adaptations.Already, more than 200 blog posts on RNA-mediated cause and effect have integrated scientific discoveries as they have appeared. Here, I will continue to explain how new scientific discoveries link food odors and pheromones to differences in the development of behavior via conserved molecular mechanisms in species from microbes to man. Intelligent discussion among self-identified participants will be encouraged.

Intro to topics/catagories?
RNA-mediated.com provides details aspects of molecular biology that link metabolic networks and genetic networkss to what is known about the molecular neuroscience of the mind. It is resource of technical information for those who want to learn more than social scientists will ever tell you about the biology of behavior. Some content is directed towards a general audience, but most people may find they are in ‘over their head’ unless they have an interest in learning about accurate representations of how differences in behavior develop.

Human Brain
Perfuming the Mind: The Biological Logic of Physical Attraction is a brief non-technical introductory article about the effect of human pheromones on hormones and human behavior. It links two award-winning technical reviews across decades of additional information to what is currently known about how pheromones effect hormones that affect behavior.

Model Organisms
Most information about animal behavior comes from model organisms and it shows that “…the only worthwhile biology is molecular biology. All else is “bird watching” or “butterfly collecting.” Bird watching and butterfly collecting are occupations manifestly unworthy of serious scientists!” — Dobzhansky (1964)

Neuronal Plasticity

Here you will find serious science. I co-authored Human pheromones: integrating neuroendocrinology and ethology, which won the “Zdenek Klein for human ethology” in 2001. Excerpt: “The effect of sensory input on hormones is essential to any explanation of mammalian behavior, including aspects of physical attraction.”

Diseases & Disorders
Comparative approaches in evolutionary psychology: molecular neuroscience meets the mind won the same award in 2002. Excerpt: “Evolutionary psychologists often overlook a wealth of information existing between the proximate genotypic level and the ultimate phenotypic level. This commonly ignored level of biological organization is the ongoing activity of neurobiological systems.”

Discoveries
From Fertilization to Adult Sexual Behavior, which I co-authored in 1996, links human pheromones to the biologically-based organization of human behavior. Evolutionary theorists have continued to overlook obvious links from food odors and human pheromones to behavior while touting their theories about mutation-initiated natural selection and the evolution of biodiversity. Here you will find accurate representations of biological facts that refute evolutionary theory. Without being labeled a “Creationist,” you can discover what makes your mind different by using information about what’s known from molecular neuroscience in the context of odors that perfume the mind.

Physics
Biophysical constraints that prevent mutations from leading to increasing organismal complexity have been virtually ignored by population geneticists. However, an extreme example of this ignorance was manifested when one book author did not ignore the biophysical constraints. Instead, he concluded that: “… genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world.” Mutation-Driven Evolution (p. 199).

Ecology
In 2014, Israeli middle-schools began to teach the theory of evolution. They now use the theory as an example of how to compare what is known about ecology to ideas that have no explanatory power. Theories do not address how ecological variation leads to ecological adaptations. Instead, theorists claim that mutation-initiated natural selection leads to the biodiversity manifested in ecological adaptations via evolution. How does evolution do that? If you start with a theory and force mutations and natural selection to fit into the context of the theory, you can explain what happened as if you understood biologically-based nutrient-dependent pheromone-controlled epigenetic cause and effect. But, sooner or later people will realize that you explained nothing about how evolution occurred. You simply insisted it did and then tried but failed miserably to explain biodiversity.

Common Scents
Claims that human pheromones don’t exist have repeatedly been made by those who have no understanding of what they are claiming. Conserved molecular mechanisms link food odors and pheromones to the biology of behavior in all species. If a species responds to food odors, the members of that species must also respond to species-specific pheromones. If not, the species is not a species because the physiology of species-specific reproduction is controlled by the metabolism of nutrients to pheromones, which links food odors and pheromones to biodiversity in all species. Those who claim human pheromones don’t exist have no insight and do not understand what’s common about common scents. For example, food odors and pheromones epigenetically effect hormones that affect behavior in all vertebrates and invertebrates.

What’s in the News
The overwhelming amount of news from scientific sources is confusing. It forces most people to specialize and only look at information that pertains to their area of expertise. This means they typically do not integrate what they read into any representation that might make what is in the news reflect what is actually known about biologically-based cause and effect. Instead, bits and pieces of information that often conflict with the representations being made continue to entice the scientifically illiterate, and lead them to believe in self-proclaimed experts whose knowledge-base is extremely limited. Meaningless results are meaningfully interpreted and that’s what most people learn about from the news.

Miscellaneous
“Neuroendocrinology is the study of the interaction between the nervous system and the endocrine system, including the biological features of the cells involved.” ” The focus of ethology is on animal behaviour under natural conditions

Searching for the Mind with Jon Lieff, M.D. also provides details that help to link human pheromones, hormones, and perfuming the mind from cell type differentiation in all cells of all inidividuals of all species to the molecular neuroscience of the mind via the conserved molecular mechanisms of biologically-based cause and effect.

RNA-directed DNA methylation links the sun’s biological energy from RNA-mediated amino acid substitutions to cell type differentiation via metabolic networks and genetic networks in plants and in animals.

Information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes will be posted here to encourage discussion of a paradigm shift.

The shift leads away from pseudoscientific nonsense about mutations and evolution to what is currently known by serious scientists about biophysically constrained nutrient-dependent protein folding. The nutrient-dependent chemistry of protein folding links ecological variation to ecological adaptations in species from microbes to man via conserved molecular mechanisms during life history transitions.

The honeybee is a model organism that best exemplifies biologically-based cause and effect. However, the molecular mechanisms that enable nutrient-dependent pheromone-controlled cause and effect are conserved in species from microbes to humans.

microRNA, messenger RNA, RNA-directed, methylation, acetylation, histone, chromosome, remodeling, epigenetic, transcription, translation, cell type, amino acid, substitution, pharmacogenomics, nutrigenomics, personalized medicine, differentiation, cancer, health, disease, physiopathology, pathophysiology, transposons, quantitative trait loci, sunlight, light, light-induced, atoms, ecosystems

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