base editing

The emergence of light as energy from a life-giving star

The Sun – our steady, reliable companion – tells a very different story up close “…a mesmerising, perspective-shaking glimpse at Earth’s life-giving star.” (video) Questions: 1) Did the energy in this life-giving star create itself? 2) How is hydrogen-atom transfer in DNA base pairs in solution biophysically constrained. 3) Who created the feedback loops that link the solar analemma from the time-space continuum to representations of biophysically constrained life and free will in the Mobius strip. 4) Was Linda Buck…

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God’s shrinking role in salvation (3)

Summary: I believe there is a bipartisan trend that links conservative Republicans to survival of the species, but I don’t know for sure what will happen to the liberal Democrats. And, I can’t prove it!   Helicity and chirality See also: God’s shrinking role in salvation (2) A Theory of Reality as More Than the Sum of Its Parts “Causal emergence is a way of claiming that your agent description is really real,” said Hoel, a postdoctoral researcher at…

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Food energy-dependent cell type differentiation (2)

Summary: The concept of “faster-evolving DNA” regions in the context of nucleotide variation in both the 16S and 12S sequences is not consistent with any accurate representation of how the functional structure of supercoiled DNA must be linked from energy-dependent changes in angstroms to ecosystems in all living genera. Conserved molecular mechanisms link the sense of smell in bacteria from the de novo creation of olfactory receptor genes to the physiology of reproduction via the microRNA/messenger RNA balance and Feynman’s…

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Synthetic RNA-based switches

Synthetic RNA-based switches for mammalian gene expression control Current Opinion in Biotechnology, Volume 48, December 2017, Pages 54–60 If you wait until December, 2017 to see this article in print, you will probably be among the last of those to have missed a two decades-old paradigm shift. The fact that these researchers created synthetic RNA-based switches attests to the fact that natural selection for energy-dependent codon optimality links what organisms eat to energy-dependent RNA-mediated amino acid substitutions. The substitutions help…

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Functionally interdependent editing and methylation

Editing and methylation at a single site by functionally interdependent activities …cytosine 32 in the anticodon loop of Trypanosoma brucei tRNAThr is methylated to 3-methylcytosine (m3C) as a pre-requisite for C-to-U deamination. Formation of m3C in vitro requires the presence of both the T. brucei m3C methyltransferase TRM140 and the deaminase ADAT2/3. Once formed, m3C is deaminated to 3-methyluridine (m3U) by the same set of enzymes. ADAT2/3 is a highly mutagenic enzyme4, but we also show that when co-expressed with…

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RNA editing refutes theistic evolution

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals January 9, 2017 Reported February 19, 2017 as A new way Forward for Gene Therapy If you want an explanation of how mRNA works within a cell, check out the video above from the Khan Academy. Unfortunately, the speaker seems to think that sickle-cell disease is caused by a mutation. All serious scientists know that the hemoglobin S variant is a biophysically constrained nutrient energy-dependent ecological…

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Light energy-induced base pair changes (2)

See: Light energy-induced base pair changes (1) To help others move forward via the concept of energy-dependent biophysically constrained RNA-mediated protein folding and what is known about how virus-driven energy theft is linked to all pathology, see also: Subatomic Particles, Part 1: Leptons Subatomic Particles, Part 2: Baryons, the Substance of the Cosmos Subatomic Particles, Part 3: Mesons If you are not ready to start from the de novo creation of the energy in a hydrogen atom, you may need…

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Hydrogen-Atom Transfer in DNA Base Pairs (4)

Historical perspective: Behold James Vaughn Kohl. Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction. These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people…

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Finding peace and π in the light of H bond energy

It might be amusing if the misrepresentations of links between energy and cell type differentiation by people like PZ Myers were not going to cause more suffering and death.  Instead, two years after his attack on me for my accurate representations of the link from nutrient energy-dependent chromosomal rearrangements to pheromone-controlled biodiversity in species from microbes to humans we see this: You’re trying to explain a random phenotype by looking for a randomization mechanism in the genome. No one will…

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Easy editing: Reinventing our RNA world

Easy DNA Editing Will Remake the World. Buckle Up. Excerpt: Most present-day animals and plants defend themselves against viruses with structures made out of RNA. My comment: RNA-mediated gene duplication and fixation of  RNA-mediated amino acid substitutions in the context of the nutrient-dependent physiology of learning, memory, and reproduction links the biophysically constrained chemistry of cell type differentiation in all genera via conserved molecular mechanisms. That fact was integrated into the science fiction novel Blood Music by Greg Bear, who…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more