Diseases & Disorders

Losers: rediscovering an epigenetic key

Epigenetic mechanisms modulate differences in Drosophila foraging behavior Little is known about how genetic variation and epigenetic marks interact to shape differences in behavior. Reported as: An epigenetic key to unlock behavior change October 16, 2017 “One of the big questions in the Child & Brain Development program over the years has been how experience gets embedded in our biology and the mechanisms for that,” says Sokolowski. See for comparison: See Brain on stress: How the social environment gets under…

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Virulence: Out of stock

Virulence: An Infectious Card Game This product is currently out of stock and is on backorder. For comparison, pre-orders of “Cytosis: A Cell Biology Board Game”  are being shipped this month, and the “board game” adds “depth” to what could already have been learned from the “card game.” I ordered two cases of “Cytosis.” Players start with the creation of energy and link ATP from the creation of RNA to the creation of all biophysically constrained life on Earth. Players…

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For God and Country

Faith in evolution: Paleontology as a molecular science

Keeping the faith For the last 20 years, Mary Schweitzer, a paleontologist at North Carolina State University in Raleigh, has amassed a wealth of evidence that she’s isolated protein fragments from dinosaurs as much as 80 million years old. That bucks the conventional wisdom among paleontologists who argue that proteins, which are made of chains of amino acids, can’t survive more than 1 million years or so. So far, no group other than Schweitzer and her collaborators has managed to…

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Lethal virus kills 5 billion people?

Until death: Virus-driven failure of multisensory integration (3)

What Your Nose Knows: Sense of Smell and Your Health August 2016 What the Nose Knows May Affect Your Brain Health October 2017 Doty’s research found a strong connection between low scores on a 40-item smell test and damage to this area of the brain. His recent article in The Lancet outlines possible ways that sense of smell and overall brain health could be linked and “may be the genesis of many neurodegenerative diseases. See: ”Olfactory dysfunction in neurodegenerative diseases:…

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For God and Country

Energy-dependent structure and function: Until death (5)

Summary: If a player starts with evolution instead of the creation of energy that links ATP to the creation of RNA, the player is a loser. Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull Secular: Ancient Viruses Are Buried in Your DNA (2017) by…

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For God and Country

Energy-dependent structure and function: Until death (4)

The structure-energy landscape of NMDA receptor gating The NMDA receptor gating is complex, exhibiting multiple closed, open, and desensitized states; however, central questions regarding the conformations and energetics of the transmembrane domains as they relate to the gating states are still unanswered. Reported as: Molecule Movements Through Nerve Cells Could Lead to Multi-functional Drugs The subunits sit on each side of the channel and activate when they bind both glutamate and glycine neurotransmitter ligands and trigger the signaling pathway that…

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For God and Country

Energy-dependent structure and function: Until death (1)

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear mechanism of gating at this site. Furthermore, the smFRET data suggest that allosteric inhibition by zinc occurs by an uncoupling of the agonist-induced changes at…

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Lethal virus kills 5 billion people?

Until death: Virus-driven failure of multisensory integration (2)

Summary: The virus-driven degradation of messenger RNA is clearly linked to frontotemporal dementia (FTD) by altered language, personality, behavior, cognition and motor function. What causes FTD? If the virus-driven degradation of messenger RNA causes all pathology, I would expect to find a link from microRNAs to the pathology and to the effective treatment. The social and economic burden of frontotemporal degeneration Reported as: Study reveals staggering economic burden of dementia in younger people Frontotemporal degeneration (FTD) accounts for 20 to…

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Biophysically constrained intelligence vs human idiocy

Microbes Mind Forum Research on origins, evolution, and syntheses of life How did self-organization and evolution give rise to complex, life-like systems and how can these dynamics inform our futures? How can we move beyond the Tragedy of the Commons as a necessary outcome of evolutionary dynamics to evolve toward sustainable futures, channeled by constraints that unleash innovative potential, designing multi-agent, problem-solving systems. Eshel Ben-Jacob is Professor of Physics of Complex Systems and holds the Maguy-Glass Chair in Physics at…

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Cryo-EM from atoms to ecosystems

Summary: I’m not going to continue repeating myself indefinitely. See: Reduced protein synthesis in schizophrenia patient-derived olfactory cells The reduced protein synthesis is a clear link from the virus-driven degradation of messenger RNA to all pathology. October 5, 2017 Lactate Metabolism in Human Lung Tumors Reported as: Study challenges long-standing concept in cancer metabolism “We were completely shocked by our findings,” said Dr. Ralph DeBerardinis, Professor at CRI, Director of CRI’s Genetic and Metabolic Disease Program, and Chief of the Division…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more