Human Brain

Epigenetic effects of stress by Bruce McEwen (1)

A rendering of how changes in an electron’s motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln Summary: In the early 1990’s, Bruce McEwen inspired my life’s works, which link the epigenetic effects of nutrient-stress and/or social stress to the fact…

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The emergence of light as energy from a life-giving star (2)

Conclusion: …all experimental evidence of biophysically constrained life on Earth begins with the creation of the sun’s energy, not with a Universe that is always looking. See: The emergence of light as energy from a life-giving star June 20, 2017 Some science journalists seem to be following my blog posts so that they can attack my claims and continue to obfuscate cause and effect.  It is difficult to place their obfuscation into the context of coincidence. For example, in my…

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MicroRNAs GnRH and the failure of sex research

Summary: “The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression” accurately represents what is known about food energy-dependent RNA-mediated cell type differentiation in species from soil microbes to humans. MicroRNAs are not new players in the hypothalamic control of fertility and the effects of food odors and pheromones on microRNAs link energy-dependent changes in hormones to behavior. That fact was detailed two decades ago in our Hormones and Behavior review. Now see: [MicroRNAs: new players…

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Food energy-dependent cell type differentiation (2)

Summary: The concept of “faster-evolving DNA” regions in the context of nucleotide variation in both the 16S and 12S sequences is not consistent with any accurate representation of how the functional structure of supercoiled DNA must be linked from energy-dependent changes in angstroms to ecosystems in all living genera. Conserved molecular mechanisms link the sense of smell in bacteria from the de novo creation of olfactory receptor genes to the physiology of reproduction via the microRNA/messenger RNA balance and Feynman’s…

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Hard Science vs the neo-Darwinian “magic box”

Summary: Identical nucleotide sequences link energy-dependent changes in binding sites to different amino acids in different proteins. The binding sites are conserved in the orthologous mammalian genes. The in vivo structure of biological membranes and evidence for lipid domains Scientists investigate how the sense of smell works in bacteria Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits As presciently predicted in the works of Richard Feynman and Bruce McEwen, bacteria feed on something that allows them to…

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From E. coli to monkeys and mankind: Theories vs models (5)

From E. coli to monkeys and mankind: Theories vs models (4) CRISPR Is Taking Over Science, Breaks Out Of Labs And Invades Schools (5/29/17) …used mathematical models to reveal that even in a uniform environment, metabolic competition generally leads to the steady coexistence of distinct microbes, collectively called a “consortium”. In a consortium, distinct microbes organize themselves to create a community-level metabolism that best exploits the nutrients present. The models showed that while growing, a consortium depletes the available pool…

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From E. coli to monkeys and mankind: Theories vs models (4)

From E. coli to monkeys and mankind: Theories vs models (3)  More Complexity with Tau Tagging and un tagging occurs at Ser214, Thr231 and Ser262 at least in order to attach to microtubules in good neurons along the axon highways. Interactions of these affect the PSD as well such as Ser212/Thr214, Ser202/Thr205, and Thr231 by altering the tau interaction with the PSD. Tau is called a “microtubule associated protein”, one of many stabilizing and regulating the vast amount of shapes…

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Energy-dependent epigenetic translation to mRNA stability (6)

See: Energy-dependent epigenetic translation to mRNA stability (5) Five energy-dependent amino acid substitutions are linked to differences in RNA content and biodiversity in 4 mammalian species. Excerpt: Species- and tissue-specific variation in mt-tRNA incorporation into the mt-LSU was analyzed….  Analysis of porcine dermal fibroblasts (C), human osteosarcoma 143B cells (D), bovine cardiac tissue (E), and rat hepatic tissue (F) depicts the relative abundance of each mt-tRNA across fractions (ImageQuant software); represented as a percentage of the total signal. In my…

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Energy-dependent epigenetic translation to mRNA stability (2)

See first: Energy-dependent epigenetic translation to mRNA stability Universe’s ultraviolet background could provide clues about missing galaxies Simulations show that there should be more small galaxies in the Universe, but UV radiation essentially stopped them from developing by depriving them of the gas they need to form stars. UV light constrains the creation of galaxies and also biophysically constrains the creation of the mutations in cancer cells. When will Stephen Hawking and other biologically uninformed theorists admit that their ridiculous…

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Ignoring peer review, ATP, and microRNA biosynthesis

Cell diversity and network dynamics in photosensitive human brain organoids …neuronal activity within organoids could be controlled using light stimulation of photosensitive cells, which may offer a way to probe the functionality of human neuronal circuits using physiological sensory stimuli. They are not going to tell anyone that these findings link the speed of light on contact with water to the energy-dependent physiology of reproduction in all living genera because the physiology of reproduction is nutrient-dependent and pheromone-controlled. Everyone knows…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more