Neuronal Plasticity

Energy-dependent physical and biophysical constraints (3)

See first: Energy-dependent physical and biophysical constraints (2) Emily Balskus Pins Down the Chemistry and Metabolism of Human Microbiomes Summary: The chemistry and metabolism of all microbiomes is food energy-dependent and pheromone-controlled via the physiology of reproduction. See: Feedback loops link odor and pheromone signaling with reproduction My comment to The Scientist: …trans-4-hydroxy-L-proline (Hyp) dehydratase, a newly discovered member of an abundant family of proteins, produced by gut bacteria, known as the glycyl radical enzymes, helps in metabolizing trans-Hyp, an…

Read More

Cell type assembly and the space-time continuum

Summary: The time to adopt energy-dependent cell type assembly as the unit of cognition was in 1944, when Schrodinger published “What is Life.” By the time Roger Penrose made his comment in the reprint edition, everyone else was too late. Penrose wrote: “How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991) See: Time (and space)…

Read More

Richard P. Feynman refuted theistic evolution

Summary: Among other delightful examples of his expertise in physics, Feynman presciently linked natural selection for energy-dependent codon optimality from food energy-dependent pheromone-controlled biophysically constrained chromosomal rearrangements to healthy longevity. He also linked the radiation-induced theft of quantized energy to mutations in phages via amino acids that increase the virulence of the viruses. Updated information is presented in the context of refutations by many others who might otherwise claim to believe in theistic evolution. The miR-23a~27a~24-2 microRNA cluster buffers transcription…

Read More

Epigenetic effects of stress by Bruce McEwen (1)

A rendering of how changes in an electron’s motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln Summary: In the early 1990’s, Bruce McEwen inspired my life’s works, which link the epigenetic effects of nutrient-stress and/or social stress to the fact…

Read More

The emergence of light as energy from a life-giving star (2)

Conclusion: …all experimental evidence of biophysically constrained life on Earth begins with the creation of the sun’s energy, not with a Universe that is always looking. See: The emergence of light as energy from a life-giving star June 20, 2017 Some science journalists seem to be following my blog posts so that they can attack my claims and continue to obfuscate cause and effect.  It is difficult to place their obfuscation into the context of coincidence. For example, in my…

Read More

MicroRNAs GnRH and the failure of sex research

Summary: “The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression” accurately represents what is known about food energy-dependent RNA-mediated cell type differentiation in species from soil microbes to humans. MicroRNAs are not new players in the hypothalamic control of fertility and the effects of food odors and pheromones on microRNAs link energy-dependent changes in hormones to behavior. That fact was detailed two decades ago in our Hormones and Behavior review. Now see: [MicroRNAs: new players…

Read More

From E. coli to monkeys and mankind: Theories vs models (4)

From E. coli to monkeys and mankind: Theories vs models (3)  More Complexity with Tau Tagging and un tagging occurs at Ser214, Thr231 and Ser262 at least in order to attach to microtubules in good neurons along the axon highways. Interactions of these affect the PSD as well such as Ser212/Thr214, Ser202/Thr205, and Thr231 by altering the tau interaction with the PSD. Tau is called a “microtubule associated protein”, one of many stabilizing and regulating the vast amount of shapes…

Read More

Feng Zhang refutes theistic evolution

Nucleic acid detection with CRISPR-Cas13a/C2c2 My summary: Their ability to detect single base differences links differences in the energy of photons to the light-induced de novo creation of RNA and to RNA-mediated amino acid substitutions that differentiate all cell types in all individuals of all living genera. Any claims about mutations and evolution have already been replaced by what serious scientists have learned about natural selection for energy-dependent codon optimality and the pheromone-controlled physiology of reproduction, which biophysically constrains all…

Read More

Respiration-dependent endogenous RNA interference

If you are a theorist, please take a deep breath before beginning to read this. The speed of light on contact with water has been linked from the level of oxygen on Earth to all biodiversity via the physiology of pheromone-controlled reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in all living genera. @jvkohl 15h15 hours ago  It’s “game over” for all theorists. There’s a new game in town. … It’s an evolutionary theory killer. @jvkohl…

Read More

Virus-driven dietary pathology (1)

Viral Trigger for Celiac Disease? A common, seemingly benign human virus can trigger an immune response that leads to celiac disease in a mouse model, researchers show. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease Editor’s summary: Viruses compound dietary pathology Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero). Both reoviruses invoked protective immune…

Read More
  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more