Nutrigenomics

Energy-dependent physical and biophysical constraints (5)

Summary: Emmy Noethe’s theorems were developed in the early 1900’s. Richard Feynman inadvertently or purposefully alluded to them as examples of human idiocy. Discover Magazine resurrected the examples of human idiocy in a 2017 article. For comparison, Choi et al., (2017) support the claims that intercellular and interkingdom communication is energy-dependent and controlled by the metabolism of food energy to pheromones. It is obvious that pheromones biophysically constrain the virus-driven degradation of messenger RNA. That fact links everything currently known…

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Energy-dependent physical and biophysical constraints (4)

Energy-dependent physical and biophysical constraints (3) Summary: Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull Microbiota Manipulations …modified an endogenous Bacteroides promoter sequence to be inducible—it could be turned on or off in mice by adding or omitting an effector molecule in the animals’…

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Energy-dependent physical and biophysical constraints (3)

See first: Energy-dependent physical and biophysical constraints (2) Emily Balskus Pins Down the Chemistry and Metabolism of Human Microbiomes Summary: The chemistry and metabolism of all microbiomes is food energy-dependent and pheromone-controlled via the physiology of reproduction. See: Feedback loops link odor and pheromone signaling with reproduction My comment to The Scientist: …trans-4-hydroxy-L-proline (Hyp) dehydratase, a newly discovered member of an abundant family of proteins, produced by gut bacteria, known as the glycyl radical enzymes, helps in metabolizing trans-Hyp, an…

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Energy-dependent physical and biophysical constraints (2)

Summary: The mind does not exist in nature. It is a manifestation of how ecological variation must be linked to the creation of food energy-dependent pheromone-controlled ecological adaptations. Energy-dependent physical and biophysical constraints (1) The energy-dependent de novo creation of all receptors is biophysically constrained. See: Channel opening and gating mechanism in AMPA-subtype glutamate receptors This was reported as: Scientists capture first image of major brain receptor in action Defects in glutamate receptors, or the processes they mediate, are implicated…

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Energy-dependent physical and biophysical constraints (1)

Summary: The hitchhiking, the epistasis, and the dynamics of adapting populations are energy-dependent and biophysically constrained in the context of RNA-mediated protein folding chemistry. The virus-driven degradation of messenger RNA links mutations to all pathology in all living genera. An upper limit on the functional fraction of the human genome For the human population to maintain a constant size from generation to generation, an increase in fertility must compensate for the reduction in the mean fitness of the population caused,…

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Cell type assembly and the space-time continuum

Summary: The time to adopt energy-dependent cell type assembly as the unit of cognition was in 1944, when Schrodinger published “What is Life.” By the time Roger Penrose made his comment in the reprint edition, everyone else was too late. Penrose wrote: “How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991) See: Time (and space)…

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Automagical disruption of an eQTL (2)

See: Automagical disruption of an eQTL (1) The automagical disruption of an eQTL, which linked rs34481144 and influenza could also have been reported in the context of this model. Nutrient-dependent/pheromone-controlled adaptive evolution: a model In the model, food energy links the pheromone-controlled physiology of reproduction in all living genera from rs34481144 and other SNPs to species-specific organism-level changes in skin, glands, and hair protection, which link ecological adaptations to protection from the virus-driven degradation of messenger RNA. Mathematical models vs. biological facts…

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Automagical disruption of an eQTL (1)

E Kaitlynn Allen et al, SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans, Nature Medicine (2017). DOI: 10.1038/nm.4370 We prioritized SNPs in IFITM3 on the basis of putative biological function and identified rs34481144 in the 5′ UTR. We found evidence of a new association of rs34481144 with severe influenza in three influenza-infected cohorts characterized by different levels of influenza illness severity. We determined a role for rs34481144 as an expression…

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Richard P. Feynman refuted theistic evolution

Summary: Among other delightful examples of his expertise in physics, Feynman presciently linked natural selection for energy-dependent codon optimality from food energy-dependent pheromone-controlled biophysically constrained chromosomal rearrangements to healthy longevity. He also linked the radiation-induced theft of quantized energy to mutations in phages via amino acids that increase the virulence of the viruses. Updated information is presented in the context of refutations by many others who might otherwise claim to believe in theistic evolution. The miR-23a~27a~24-2 microRNA cluster buffers transcription…

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MicroRNAs GnRH and the failure of sex research

Summary: “The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression” accurately represents what is known about food energy-dependent RNA-mediated cell type differentiation in species from soil microbes to humans. MicroRNAs are not new players in the hypothalamic control of fertility and the effects of food odors and pheromones on microRNAs link energy-dependent changes in hormones to behavior. That fact was detailed two decades ago in our Hormones and Behavior review. Now see: [MicroRNAs: new players…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more