Pharmacogenomics

A null mutation and healthy longevity?

Summary: Food odors and pheromones biophysically constrain all pathology in species from microbes to humans. What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana? Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia Reported as: How to Control…

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From base editing to RNA editing (4)

Summary: To claim evolution, Koonin must link food energy from the pheromone-controlled physiology of reproduction to fixation of a beneficial mutation in the organized genome of one species that evolved into another species. Search Results for “base editing” = 82 blog posts starting with Cell-type differentiation on February 7, 2014 Search Results for “RNA editing” = 95 blog posts starting with In theory, or supported by experimental evidence? October 22, 2014 See for comparison PubMed: “base editing” (33 citations) and…

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Long-term adaptation replaces evolution (3)

Summary: Koonin thinks that serious scientists who have linked the creation of energy to all biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans must prove that everything the serious scientists know did not occur randomly after the sun’s anti-entropic virucidal energy emerged from nothing. Other pseudoscientists have taken a step towards refuting Koonin’s moronic claim with publication of: A mammalian blood odor component serves as an approach-avoidance cue across phylum border – from flies to…

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Lethal virus kills 5 billion people?

Until death: Virus-driven failure of multisensory integration (2)

Summary: The virus-driven degradation of messenger RNA is clearly linked to frontotemporal dementia (FTD) by altered language, personality, behavior, cognition and motor function. What causes FTD? If the virus-driven degradation of messenger RNA causes all pathology, I would expect to find a link from microRNAs to the pathology and to the effective treatment. The social and economic burden of frontotemporal degeneration Reported as: Study reveals staggering economic burden of dementia in younger people Frontotemporal degeneration (FTD) accounts for 20 to…

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1996-2016: Ignoring alternative splicings of pre-mRNA

Range of diseases may result when brain self-regulation goes awry, researchers say There is no such thing as self-regulation of the brain. Regulation is food energy-dependent and biophysically constrained by changes in the microRNA/messenger RNA balance. The entire range of diseases is linked from the virus-driven degradation of messenger RNA to the mutations that some theorists claim may sometimes be beneficial.The theorists the make those ridiculous claims are biologically uninformed science idiots. See for comparison: Microprocessor Recruitment to Elongating RNA…

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For God and Country

Sci-Hub vs limits on the dissemination of information

The ideology of “Americanism” is not consistent with the tactics of academics and politicians that constrain release of accurate information about  biologically-based cause and effect. …Americanism is an ideology, or belief in devotion, loyalty, or allegiance to the United States of America, or to its flag, traditions, customs, culture, symbols, institutions, or form of government.[2] In the words of Theodore Roosevelt, “Americanism is a question of spirit, conviction, and purpose, not of creed or birthplace.”[3] Americanism has two different meanings.…

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Evolution outside the context of “the light of evolution”

Summary: The claim that two mutations led to the weekend resurrection of the bacterial flagellum cannot be supported with the claim that only one amino acid substitution differentiates the cell type of two different primate species (gorillas and humans) from two similar species (chimpanzees and humans). The fact that mutations are not amino acid substitutions can be supported in the context of food energy-dependent pheromone-controlled cell type differentiation in species from microbes to humans. Nothing in Biology Makes Any Sense…

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New Testament Book Cover Refutes Theistic Evolution

Video of Biology of the Book Goats, bookworms, a monk’s kiss: Biologists reveal the hidden history of ancient gospels Collins already had developed a method to identify ancient species by differences in the amino acid sequences of collagen and other proteins preserved in fossils. See: Protein power by Robert F. Service …methods to sequence amino acids lag behind DNA sequencing. The report of 300 million year old proteins is based on ridiculous theories that failed to include what was known about…

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Energy-dependent physical and biophysical constraints (10)

Summary: The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…— Eugene Koonin My comment: Viruses are not life forms. They steal the quantized energy that links sunlight to viral latency in the context of everything known to all serious scientists about the fact that Feedback loops link odor and pheromone signaling with reproduction See for comparison: Olfaction Warps Visual…

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The Virus-Driven Suicide March for Science

Genetic analysis of α-synuclein 3′ untranslated region and its corresponding microRNAs in relation to Parkinson’s compared to dementia with Lewy bodies My summary: Genetic predispositions and energy-dependent microRNA biogenesis link top-down causation to the biophysically constrained transgenerational epigenetic inheritance of neuronal type-specific expression.  Energy-dependent variability in endogenous RNA interference and the SNCA gene contribute to synucleinopathies in the context of two different human pathologies. Virus-driven energy theft is linked to the regulation of the α-synuclein (SNCA) gene and the etiology…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more