Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression Excerpt: “…glucose consumption by tumors metabolically restricts T cells, leading to their dampened mTOR activity, glycolytic capacity, and IFN-γ production, thereby allowing tumor progression.” My comment: Does anyone know the difference between 1) a tumor that eats glucose and 2) viruses that steal … Metabolic competition and cancer
The Octopus Genome: Not “Alien” but Still a Big Problem for Darwinism by Casey Luskin, August 24, 2015 Excerpt: Whenever you see “de novo” origin of a gene invoked, you know that evolutionary biologists lack any explanation for how that gene arose. My comment: I tend to use the experience-dependent “de novo” creation of olfactory … Creating genes and species
See also: A “new” code enables ecological adaptation For comparison, see: Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell Excerpt: Single-molecule and single-cell studies reveal behaviors that are hidden in bulk measurements (1, 2). In a human cell, the genetic information is encoded in 46 chromosomes. The variations occurring in these … Cell types, SNVs, CNVs, and chromosomes
Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity Excerpt: …it was hypothesized that hsf-1 regulates the aging process by modulating chaperone network components to directly influence the folding state of the proteome ( Morimoto, 2008). Our data suggest an alternate method by which hsf-1 can regulate the aging process. In this model, hsf-1 activates … Thermotolerance and Longevity
If life hangs in the balance between quantum and classical physics, the anti-entropic effect of the sun’s biological energy is what keeps it hanging, albeit not indefinitely. Until you consider the fact that viruses link entropic elasticity to genomic entropy in all genera, you may not realize that your life hangs in the balance between … Is life the balance between quantum and classical physics?
Scientists explore the origins of energy in chemical reactions using experimental quantum chemistry Excerpt: One thing that all chemical reactions have in common—whether they are the reactions that take place inside a battery, the metabolic reactions inside a living organism, or the combustion reactions that cause an explosion—is that they all involve some kind of … Anti-entropic containment of energy: symbiosis 1.0
Secrets of the Deep: Scientists Sequence Genome of Octopus for First Time Excerpt: The genome was arranged differently than in other invertebrates and featured an expansion in a family of genes regulating nerve cell development that previously was thought to be enlarged only in vertebrates. My comment: RNA-mediated gene duplication and RNA-mediated amino acid substitutions … Olfaction & the octopus and human genomes
My model links the biophysically constrained fixation of nutrient-dependent RNA-mediated amino acid substitutions to the stability of organized genomes. Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Nutrient-dependent pheromone-controlled stability of organized genomes has since been placed into the context of anti-aging medicine, as I did in presentations from 1994 and 1995. See: Repression of the Heat Shock … Thermodynamic constraints did not evolve
Excerpt: “We have detected formamide in five protosuns, which proves that this molecule (in all probability also true for our Solar System) is relatively abundant in molecular clouds and is formed in the very early stages of evolution towards a star and its planets…” My comment: Finding a molecule in five or more protsuns proves … Protosuns, prebiotic molecules, proteins, and people
See: A universal trend of amino acid gain and loss in protein evolution (2005) Excerpt: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. My comment: The fact that something varies between taxa does not mean that it evolved. Eugene Koonin is the senior author on an article, which appears to … Ecological speciation vs revised evolutionary syntheses
