Pharmacogenomics

The end of neo-Darwinism

Rapid bacterial infection test reduces antibiotic use Excerpt: The rapid tests detect C-reactive protein (CRP), a marker of infections caused by bacteria, in patients’ blood. A low level of CRP is suggestive of viral infection and therefore antibiotic treatment is not required. My comment: The level of one protein differentiates between a viral and a bacterial infection. That fact attests to claims that one RNA-mediated amino acid substitution in a virus increases its virulence. The major antigenic changes of the…

Read More

Biophotonics, glycobiology, quantized biodiversity

Historical perspective: From Fertilization to Adult Sexual Behavior Excerpt: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may…

Read More

The Origin of Information (2)

See also: The Origin of Information (1) Labroots Neuroscience virtual event: RNA mediated molecular epigenetics and virus driven entropy (working title: The Origin of Information) Published to Youtube March 2, 2016 RNA mediated molecular epigenetics and virus driven entropy Presented March 16 and 17, 2016  Login for free and go to the Poster Hall section on Neuron Biology for a full screen display of the poster or view the poster on Figshare Abstract: Energy-dependent molecular epigenetics support Einstein’s complete molecular…

Read More

The Origin of Information (1)

Labroots Neuroscience virtual event: YouTube video < 10 minutes. From hydrogen atom transfer in DNA base pairs to ecosystems Published on 2 Mar 2016 Presented March 16 and 17, 2016  Login for free and go to the Poster Hall section on Neuron Biology for a full screen display of the poster or see the poster displayed on Figshare Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on DNA base pairs in solution and RNA-mediated amino…

Read More

Did “Nature” kill Steve Jobs? (3)

So Many Research Scientists, So Few Openings as Professors Excerpt: Even someone as brilliant as Emmanuelle Charpentier, who in 2015 became head of the Max Planck Institute for Infection Biology after a momentous discovery in gene editing, spent the previous 25 years moving through nine institutions in five countries. My comment: Why did she move around so much when in the same year, on 07/02/2015, George Church and colleagues filed a patent application for “RNA-Guided Human Genome Engineering.” Excerpt: Repetitive…

Read More

Funding the Human Genome Project-Write

The Genome Project-Write Excerpt: …understanding of genetic blueprints could come from construction of large, gigabase (Gb)-sized animal and plant genomes, including the human genome, which would, in turn, drive development of tools and methods to facilitate large-scale synthesis and editing of genomes. To this end, we propose the Human Genome Project-Write (HGP-write), named to honor HGP-read but embracing synthesis of all large genomes. My comment: Synthesis is nutrient energy-dependent and the synthesis of all large genomes links the innate immune…

Read More

Did “Nature” kill Steve Jobs? (2)

See also: Did “Nature” kill Steve Jobs? In my model of biophysically constrained energy-dependent protein folding chemistry and RNA-mediated cell type differentiation, the nutrient-dependent pheromone-controlled physiology of reproduction links the innate immune system to supercoiled DNA, which protects all organized genomes from virus-driven entropy. For comparison to my model, see: Evolution 2016 Videos (Indexed) Youtube videos Posters See also for comparison: Viruses Have Guided the Path of Human Evolution Excerpt: Whenever a viral epidemic tears through a community, there are…

Read More

Virus-driven downsizing of the human brain (2)

The effects of virus-driven energy theft on brain development in mammals typically occur more rapidly during gestation and early prenatal development. That’s why the connection from biophysically constrained RNA-mediated amino acid substitutions and protein folding chemistry during life history transitions has been largely ignored. Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb Excerpt: …coordinated structural plasticity is consistent with stable, yet flexible, decorrelated sensory representations. Together, our study reveals that persistent, coordinated synaptic structural plasticity between interneurons…

Read More

RNA methylation (revisited)

N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification Excerpt: …the reversible and dynamic m6A RNA methylation, the most prevalent internal modification in mRNA, plays broad and key roles in diverse biological processes. Through the functional interactions with m6A methyltransferases, demethylases, and m6A-binding proteins, this epigenetic modification affects various aspects of RNA metabolism, including mRNA transcription, splicing, nuclear export, localization, translation and stability, and post-transcriptional regulate gene expression at the RNA level. Conclusion:  Indeed, breakthrough discoveries…

Read More

Placing boundaries where none exist

Epigenome-wide Association Studies and the Interpretation of Disease -Omics Reported by Carl Zimmer in:  Growing Pains for Field of Epigenetics as Some Call for Overhaul Excerpt: these experts “…argue that in some cases, changes to epigenetic marks don’t cause disease, but are merely consequences of disease. My comment: What kind of biologically uninformed expert or science journalist continues to misrepresent what is known to serious scientists about all virus-driven pathology? See for comparison: Epigenetics and Genetics of Viral Latency Excerpt:…

Read More
  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more