RNA-directed DNA methylation

Lethal virus kills 5 billion people?

Until death: Virus-driven failure of multisensory integration (2)

Summary: The virus-driven degradation of messenger RNA is clearly linked to frontotemporal dementia (FTD) by altered language, personality, behavior, cognition and motor function. What causes FTD? If the virus-driven degradation of messenger RNA causes all pathology, I would expect to find a link from microRNAs to the pathology and to the effective treatment. The social and economic burden of frontotemporal degeneration Reported as: Study reveals staggering economic burden of dementia in younger people Frontotemporal degeneration (FTD) accounts for 20 to…

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Biophysically constrained intelligence vs human idiocy

Microbes Mind Forum Research on origins, evolution, and syntheses of life How did self-organization and evolution give rise to complex, life-like systems and how can these dynamics inform our futures? How can we move beyond the Tragedy of the Commons as a necessary outcome of evolutionary dynamics to evolve toward sustainable futures, channeled by constraints that unleash innovative potential, designing multi-agent, problem-solving systems. Eshel Ben-Jacob is Professor of Physics of Complex Systems and holds the Maguy-Glass Chair in Physics at…

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Until death: Virus-driven failure of multisensory integration (1)

Martha McClintock‘s works inspired my works. Publication of “The Scent of Eros: Mysteries of Odor Human Sexualty” (1995) led Denise Chen to study olfaction and pheromones. See for example: Encoding human sexual chemosensory cues in the orbitofrontal and fusiform cortices. Her student, Wen Zhou, returned to China and she is the senior author of Olfaction Warps Visual Time Perception. Since 1995, all accurate representations of how foraging behavior links food odors and pheromones from feedback loops to sexual reproduction and…

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Lethal virus kills 5 billion people?

Entertaining yourself to death

Summary: Food energy is required for the creation of enzymes that metabolize the food, which links the metabolism to the pheromone-controlled physiology of reproduction in species from microbes to humans via alternative splicings of pre-mRNAs, which are now called microRNAs in more than 65,000 published works. The horrid tradjedy of of yet another preventable death by suicide extends those works to preventing the cause of death of those killed by Stephen Paddock. Vegas gunman transferred $100K, set up cameras at…

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Predicting who wins the 2017 Nobel Prizes (6)

I failed to correctly predict who would win this year’s Nobel Prize in Chemistry, but there is still hope for my prediction of who will win the Nobel Peace Prize. I thought Lynn Zechiedrich would win for linking cryo-EM to the Structural diversity of supercoiled DNA Our cryo-ET, biochemical, and computational studies show the astounding versatility and dynamism of DNA depending on the degree of supercoiling. DNA simultaneously exists in a largely inactive B-form with bases tucked in and protected…

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Criticisms of a validated model

Microglia Turnover in the Human Brain “With electron microscopy, we find a variety of immune cells in the brain, especially in contexts of disease,” she writes. Richard Feynman predicted this in the context of a lecture on nanotechnology. He presciently placed cryo-EM into the context of a lecture about Plenty of Room at the Bottom. Examination at this level of observable energy-dependent top-down causation has since linked the sun’s anti-entropic virucidal energy from hydrogen-atom transfer in DNA base pairs in…

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Thanks again for asking about DNA methylation

Re: RNA-directed DNA methylation (1996) See: From Fertilization to Adult Sexual Behavior Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. See also: RNA-directed DNA methylation: an epigenetic…

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Predicting who wins the 2017 Nobel Prizes (3)

Summary: The unique mechanism detailed in the context of “Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression” is obviously not a unique mechanism. The mechanism exemplifies the fact that RNA-directed DNA methylation is energy-dependent and the fact that virus-driven energy theft causes the degradation of messenger RNA, which serious scientists have linked to all pathology. My failure to accurately predict who would win the 2017 Nobel Prize in Physiology or Medicine can now be placed into…

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Lethal virus kills 5 billion people?

Predicting who wins the 2017 Nobel Prizes (2)

Summary: Endogenous RNA interference is the energy-dependent epigenetic link from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency. The stress-linked virus-driven degradation of messenger RNA has been linked to all pathology. Three Americans win Nobel medicine prize for body rhythm work [But they failed to link Americanism to Creationism] I predicted that Wen Zhou would win for linking the energy-dependent creation of G protein-coupled receptors to all biodiversity via olfaction and the space-time continuum in the context of…

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Lethal virus kills 5 billion people?

Predicting who wins the 2017 Nobel Prizes

The Nobel Prize in Physiology or Medicine 2017 will be announced on Monday 2 October, 11:30 a.m. at the earliest. The Nobel Prize in Physics 2017 will be announced on Tuesday 3 October, 11:45 a.m. at the earliest. The Nobel Prize in Chemistry 2017 will be announced on Wednesday 4 October, 11:45 a.m. at the earliest. The Nobel Prize in Literature 2017 According to tradition, the Swedish Academy will set the date for its announcement later. The Nobel Peace Prize…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
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