RNA-directed DNA methylation

Neuroscience Virtual Event vs AAAS Symposium

Neuroscience Virtual Event Abstract Submission Poster title: From hydrogen-atom transfer in DNA base pairs to ecosystems (March 16-17, 2016) Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on DNA base pairs in solution and RNA-mediated amino acid substitutions to chromosomal rearrangements via pheromone-controlled changes in the microRNA / messenger RNA balance. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent & pH-dependent protein folding; experience-dependent receptor-mediated behaviors,…

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Cancer: Evolution 2.0’s Blind Spot

See also: Hydrogen-atom transfer in DNA base pairs (5) Hydrogen-atom transfer in DNA base pairs (5) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems Excerpt: …methylation of the carbon-5 position of cytosine, which results in differences in 5hmCs, may be the most commonly studied type of nutrient-dependent pheromone-controlled structural and functional eukaryotic modification that results from organizing base pair changes. Team uses internet network theory to decipher the first epigenetic communication network Excerpt: … 5hmC regulates changes in the compaction…

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Despicable fools?

Metamaterial Offers Simpler Route to Slow Light Excerpt: Light is generally accepted to travel at a constant speed, but its group velocity can be slowed by passing through refractive materials. Compared to its top speed in a vacuum, light travels slightly slower in air and slightly slower still in water. These changes in speed are fairly insignificant, however. My comment: I doubt that any member of the RNA society thinks that the changes that link the de novo creation of…

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Ricki Lewis’ Time Machine (2)

See also: Can a Quirky Chromosome Create a Second Human Species? Reported here as: Ricki Lewis’ Time Machine Physics’s pangolin Trying to resolve the stubborn paradoxes of their field, physicists craft ever more mind-boggling visions of reality Excerpt 1) with my emphasis Physicists are deeply aware of the schizophrenic nature of their science and long to find a synthesis, or unification. Such is the goal of a so-called ‘theory of everything’. However, to non-physicists, these competing lines of thought, and…

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Hydrogen-atom transfer in DNA base pairs (6)

Mobile small RNAs regulate genome-wide DNA methylation Abstract excerpt: RNA silencing at the transcriptional and posttranscriptional levels regulates endogenous gene expression, controls invading transposable elements (TEs), and protects the cell against viruses. Conclusion:  Our conclusions underpin future research into why plants possess a system for communicating methylation status from shoot to root tissues. See also: Tumor-suppressing gene restrains mobile elements that can lead to genomic instability Excerpt: The investigators found that normal p53 gene action restrains transposons, mobile genetic elements…

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RNA-mediated repurposing in microbes and adaptations in primate brains

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion Excerpt: “…the C-terminal 47 amino-acids of ARHGAP11B (after lysine-220) constitute not only a unique sequence, resulting from a frameshifting deletion (fig. S10), but also are functionally distinct from their counterpart in ARHGAP11A.” My comment: Co-author Svante Paabo is the senior author of this 2003 publication: Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees The 2015 publication was reported as: A gene for brain size only found…

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Physicists: Desperate Acts

Participation on the FB group Thinking Allowed Original led to an invite by Ulla Mattfolk to participate on her secret group  Quantum Biology, coherence and decoherence. On January 22 at 11:45pm, discussion led me to ask whether biophotonic energy differences could be recognized by the photons at the quantum level of their interactions/energies. I thought the answer might explain biodiversity via a link from quantum level self – other recognition to immune system recognition and to macromolecular self – other recognition. My focus has been on well-established…

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Are mutations beneficial?

Researchers develop non-invasive method to detect tumor-causing mutations in saliva Excerpt: “…a multiplexible electrochemical sensor uses electrode chips to enable vesicular entities in saliva called exosomes to rapidly release molecular constituents (DNA, RNA and proteins) while simultaneously detecting any mutations in tumor-causing DNA sequences. The total detection time is less than 10 minutes and required a small saliva sample.” My comment: This news about multiplexing attests to the complexity of systems biology, which links amino acid substitutions to mutated DNA…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more