RNA–Mediated Epigenetic Heredity

RNA-mediated everything

Odorant receptor gene choice and axonal wiring in mice with deletion mutations in the odorant receptor gene SR1 Abstract: In the mouse, a mature olfactory sensory neuron (OSN) of the main olfactory epithelium (MOE) expresses one allele of one of the 1200 odorant receptor (OR) genes in the genome. The mechanisms that underlie the one receptor–one neuron rule remain poorly understood. A popular experimental paradigm for OR gene choice is to delete an OR coding region by gene targeting or…

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The Sherlock lab: Beneficial mutations

After he challenged me in a discussion of two works on tardigrades, Gavin Sherlock‘s comments were removed from the facebook page of Serafim Batzoglou. In the context of The genome of the tardigrade Hypsibius dujardini and Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade, it quickly became clear that Gavin Sherlock knows nothing about how cell type differentiation occurs. Sherlock is the senior author of Quantitative evolutionary dynamics using high-resolution lineage tracking Excerpt: Our results…

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Neo-Darwinism vs the neocortex

From Fertilization to Adult Sexual Behavior Excerpt: (with my emphasis) Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to c in at least two species, Drosophila melanogaster and Caenorhabditis elegans…. That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes. Alternative splicing as a switch to enhance neuroprotection under stress Excerpt: Alternative splicing is an important post-transcriptional…

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A two-faced protein enables RNA-mediated DNA repair

Janus: …is the god of beginnings and transitions,[1] and thereby of gates, doors, doorways, passages and endings. He is usually depicted as having two faces, since he looks to the future and to the past. My comment: Nutrient-dependent beginnings of morphological and behavioral diversity are biophysically constrained by the physiology of species-specific RNA-mediated DNA repair in the context of reproduction. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains Excerpt: Despite barely conserved primary sequences (Supplementary Fig.…

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Life and death predicted by DNA methylation

The bounce rate here has more than doubled  (from 20% to 44%) during the past week at the same reports continue to support all the claims I have made about RNA-mediated cell type differentiation. Obviously, pseudoscientists are not willing to examine any evidence of biologically-based cause and effect that refutes their ridiculous claims about mutations and evolution. For comparison, serious scientists will want to read this: See: DNA methylation age is associated with mortality in a longitudinal Danish twin study…

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Organization of biological sequences

The organization of biological sequences into constrained and unconstrained parts determines fundamental properties of genotype–phenotype maps Excerpt: Biological evolution is characterized by the inheritance, mutation and translation of biological information. My comment: Genome organization is nutrient-dependent and controlled by the physiology of reproduction in all living genera. Nutrient-dependent RNA mediated gene duplication and RNA-mediated amino acid substitutions link RNA-mediated protein folding  chemistry from supercoiled DNA to protection against virus driven genomic entropy via the physiology of reproduction. Virus-driven genomic entropy…

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Plasma created by sunlight and RNA–mediated epigenetic heredity

Australian student confirms that giant plasma tubes are floating above Earth Excerpt: The region of space around the Earth occupied by its magnetic field, called the magnetosphere, is filled with plasma created by the atmosphere being ionised by sunlight. My comment: Scientists have believed in the creation of these structures for more than 60 years. Now visual evidence confirms structures exist that are created by sunlight on contact with the Earth’s atmosphere. This reminds me of what someone who was…

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Are mutations beneficial?

Researchers develop non-invasive method to detect tumor-causing mutations in saliva Excerpt: “…a multiplexible electrochemical sensor uses electrode chips to enable vesicular entities in saliva called exosomes to rapidly release molecular constituents (DNA, RNA and proteins) while simultaneously detecting any mutations in tumor-causing DNA sequences. The total detection time is less than 10 minutes and required a small saliva sample.” My comment: This news about multiplexing attests to the complexity of systems biology, which links amino acid substitutions to mutated DNA…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more