RNA-mediated gene silencing

Virucidal effects on ecological speciation

An Adaptor Hierarchy Regulates Proteolysis during a Bacterial Cell Cycle Abstract excerpt: …additional factors are inexplicably required for cell-cycle-dependent proteolysis. Here, we show that these factors constitute an adaptor hierarchy wherein different substrates are destroyed based on the degree of adaptor assembly. Abstract conclusion: Our work reveals how hierarchical adaptors and primed proteases orchestrate regulated proteolysis during bacterial cell-cycle progression. My comment:  The use of the term “adaptor hierarchy” brought this article to my attention. The term “adaptor hierarchy” is…

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Let there be anti-entropic light (2)

Predicted Inactivation of Viruses of Relevance to Biodefense by Solar Radiation (2005)Excerpt: Sunlight or, more specifically, solar UV radiation (UV) acts as the principal natural virucide in the environment. UV radiation kills viruses by chemically modifying their genetic material, DNA and RNA. See also: Let there be anti-entropic light (1) Excerpt: Nutrient-stress and social stress contribute to the accumulation of viral miRNAs that would typically be prevented by nutrient-dependent pheromone-controlled feeback loops that link food odors and social odors to…

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Anti-entropy: an evolutionist’s afterthought

Enlarge the diagram to see that pheromones are linked to longevity via signaling and chromatin modifiers. Epigenetic regulation of ageing: linking environmental inputs to genomic stability Excerpt 1) The longevity of worms and flies can be modulated by the opposite sex82,123,124 a process that can involve pheromone production and/or sensing82,124 Excerpt 2) As secondary metabolites are evolutionarily conserved, the potential links between pheromonal signalling, chromatin and ageing deserve further exploration in other species. My comment: The stability of organized genomes…

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Foundamentals of theory

There are foundations of epigenetics and fundamentals of molecular mechanisms. They have been detailed in this atoms to ecosystems model of RNA-mediated cell type differentiation. Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems. I have never seen anyone mention the “foundamentals” of epigenetics. It appears the word has been invented. Similarly, the word “mutation” was invented in 1904 by de Vries. Inventing words and defining them to fit ridiculous theories about neo-Darwinian evolution is required to continue convincing theorists that…

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Nutrient-dependent RNA-directed DNA methylation

Pattern recognition Establishing, maintaining and modifying DNA methylation patterns in plants and animals Excerpt: FIGURE 2 | Model for RNA-directed DNA methylation. Download high-resolution Power Point slide (112 KB) Where did this pattern come from? It is clearly a consideration in the context of Sensory feedback shapes individuality to provide equal space for behavioral excellence and in Feedback loops link odor and pheromone signaling with reproduction. The pattern went missing in this report: Algal ancestor of land plants was preadapted…

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Microbes to humans 2015 Nobel Prize

3 Scientists Win Nobel Prize in Medicine for Parasite-Fighting Therapies Excerpt 1) Success in antimalarial therapy depends on how clever scientists are in using combinations of drugs. Excerpt 2) Dr. Omura played down his accomplishments, saying, “I merely borrowed the power of microbes.” My comment: These two excerpts appear within the context of three paragraphs that clearly link RNA-mediated cell type differentiation in species from microbes to humans. The context attests to what at first may appear to be a…

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Non-mainstream scientist shares Nobel prize in Medicine

Youyou Tu is the 12th women awarded the Nobel Prize in Physiology or Medicine (2015) for her discoveries concerning a novel therapy against Malaria. Historical perspective: Lasker~DeBakey Clinical Medical Research Award Excerpt: Tu discovered a passage in the Handbook of Prescriptions for Emergencies (340 CE) by Ge Hong that referenced Qinghao’s malaria-healing capacity. It said “Take a handful of Qinghao, soak in two liters of water, strain the liquid, and drink.” She realized that the standard procedure of boiling and…

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Is mainstream science in “Science” pseudoscience?

See: Single neuron may carry over 1,000 mutations (with my comments),  A natural history of neurons: Diverse mutations reveal lineage of brain cells (with my comments), and Study examines scale of gene mutations in human neurons, All three of the links above are to reports on the study results published as: Somatic mutation in single human neurons tracks developmental and transcriptional history Excerpt 1) We also observed a signature of methylated cytosine (meC) to thymine (T) transitions (fig. S8), which…

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RNA Mediated

Metaphysical science vs theory

I’ve wasted too much time attempting to explain biologically-based facts to the biologically uninformed discussants on Science X network. This is an attempt to salvage some of the time and to move forward.  See: New comments posted on Science X network: – A natural history of neurons: Diverse mutations reveal lineage of brain cells : 1 new comment – Study sheds light on powerful process that turns food into energy : 1 new comment – Study adds to evidence that…

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Do young neurons in the brain evolve?

Brain Gain Young neurons in the adult human brain are likely critical to its function. By Jef Akst | October 1, 2015 Excerpt “The rate at which [new neurons] incorporate is dependent upon experience,” Gage says. My comment: The experience-dependent de novo creation of olfactory receptor genes is the basis for the following representation of biologically-based cause and effect: Feedback loops link odor and pheromone signaling with reproduction Virus-perturbed nutrient-dependent RNA-mediated protein folding biochemistry is the clearest link from nutrient-stress…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more