RNA-mediated toxicity

Sulfated steroids and RNA-mediated identity codes

Sulfated steroids and RNA-mediated identity codes Summary: In two studies of human pheromones we linked a mixture of androsterone and androstenol to increased flirtatious behavior and reports of increased attraction to the male wearing the mixture. This blog posts explains the reason for the use of those two chemicals in the context of what is currently known to serious scientists about cell type differentiation in all living genera. Excerpt: Sequencing both microRNA and mRNA enabled us to identify changes on…

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RNA-mediated everything

Odorant receptor gene choice and axonal wiring in mice with deletion mutations in the odorant receptor gene SR1 Abstract: In the mouse, a mature olfactory sensory neuron (OSN) of the main olfactory epithelium (MOE) expresses one allele of one of the 1200 odorant receptor (OR) genes in the genome. The mechanisms that underlie the one receptor–one neuron rule remain poorly understood. A popular experimental paradigm for OR gene choice is to delete an OR coding region by gene targeting or…

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The Sherlock lab: Beneficial mutations

After he challenged me in a discussion of two works on tardigrades, Gavin Sherlock‘s comments were removed from the facebook page of Serafim Batzoglou. In the context of The genome of the tardigrade Hypsibius dujardini and Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade, it quickly became clear that Gavin Sherlock knows nothing about how cell type differentiation occurs. Sherlock is the senior author of Quantitative evolutionary dynamics using high-resolution lineage tracking Excerpt: Our results…

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Are mutations beneficial?

Researchers develop non-invasive method to detect tumor-causing mutations in saliva Excerpt: “…a multiplexible electrochemical sensor uses electrode chips to enable vesicular entities in saliva called exosomes to rapidly release molecular constituents (DNA, RNA and proteins) while simultaneously detecting any mutations in tumor-causing DNA sequences. The total detection time is less than 10 minutes and required a small saliva sample.” My comment: This news about multiplexing attests to the complexity of systems biology, which links amino acid substitutions to mutated DNA…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more