RNA methylation

What energy source do proteins prefer?

Quantized energy as information is the anti-entropic virucidal source of healthy longevity. All pathology is caused by virus-driven energy theft. Impact of cytosine methylation on DNA binding specificities of human transcription factors …many developmentally important proteins display preference for mCpG-containing sequences.   How do proteins display a preference for anything except food and codon optimality? Natural selection for quantized food energy-dependent codon optimality links the structure and function of supercoiled DNA to protection from virus-driven energy theft. That fact was…

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Ignoring peer review, ATP, and microRNA biosynthesis

Cell diversity and network dynamics in photosensitive human brain organoids …neuronal activity within organoids could be controlled using light stimulation of photosensitive cells, which may offer a way to probe the functionality of human neuronal circuits using physiological sensory stimuli. They are not going to tell anyone that these findings link the speed of light on contact with water to the energy-dependent physiology of reproduction in all living genera because the physiology of reproduction is nutrient-dependent and pheromone-controlled. Everyone knows…

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All of “like kind” in the (bigger) family (2)

See first: All of “like kind” in the (bigger) family Excerpt: Researchers who want to understand why the changes occur should be among the first to examine how fixation of the amino acid substitutions occurs in the DNA of organized genomes. For example, fixation of amino acid substitutions appears to occurs via the nutrient-dependent pheromone-controlled physiology of reproduction in species from microbes to man. Instead SICB dictator Billie Swalla and her co-authors made a ridiculous claim. How could their data…

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Feng Zhang refutes theistic evolution

Nucleic acid detection with CRISPR-Cas13a/C2c2 My summary: Their ability to detect single base differences links differences in the energy of photons to the light-induced de novo creation of RNA and to RNA-mediated amino acid substitutions that differentiate all cell types in all individuals of all living genera. Any claims about mutations and evolution have already been replaced by what serious scientists have learned about natural selection for energy-dependent codon optimality and the pheromone-controlled physiology of reproduction, which biophysically constrains all…

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What is life without sunshine?

Summary: It seems likely that Schrodinger’s anti-entropic virucidal effect of sunlight will be linked to the RNA-mediated de novo creation of all organized genomes and the maintenance of the “spotless epigenome” in this presentation later today. If so, even theorists and other pseudoscientists who planned to “March for Science” will finally be seen in the context of Dobzhansky’s claims about the “…light of evolution.” Erasing Epigenetic Marks: Eternal Sunshine of the Spotless Epigenome Topics to be covered: The variety of…

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Viruses in pathogenic variants disrupt alternative splicings (2)

Autophagy is activated by virus-driven energy theft. Click on the term “Autophagy” That fact is clear in the diagram of systems complexity and in my model. See for contrast:  Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors A key question in virology, that is potentially answerable using paleovirological analyses, is what caused the elimination of extinct viral lineages? Conclusion: The selection pressures acting on hsaHTenv, its orthologs and progenitors might have been complex. Loss of fusogenicity…

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Viruses in pathogenic variants disrupt alternative splicings

Pathogenic variants that alter protein code often disrupt splicing Approximately 10% of exonic mutations altered splicing, mostly by disrupting multiple stages of spliceosome assembly. We present a large-scale characterization of exonic splicing mutations using a new technology that facilitates variant classification and keeps pace with variant discovery. Assay of nearly 5,000 mutations reveals roots of genetic splicing errors “Splicing errors can be very deleterious because instead of just changing one amino acid [the building block of a protein], it can…

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Respiration-dependent endogenous RNA interference

If you are a theorist, please take a deep breath before beginning to read this. The speed of light on contact with water has been linked from the level of oxygen on Earth to all biodiversity via the physiology of pheromone-controlled reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in all living genera. @jvkohl 15h15 hours ago  It’s “game over” for all theorists. There’s a new game in town. https://www.kicktraq.com/projects/geniusgames/cytosis-a-cell-biology-board-game/ … It’s an evolutionary theory killer. @jvkohl…

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Epigenetically-effected nucleosome repositioning sheds Dobzhansky’s light on evolution

Crystal structure of the overlapping dinucleosome composed of hexasome and octasome My summary: Nucleosomes are dynamic entities that are repositioned by energy-dependent links from sunlight to ATP and RNA biosynthesis that act on DNA during the chromatin remodeling, which is biophysically constrained by the pheromone-controlled physiology of reproduction during the transgenerational epigenetic inheritance of all morphological and behavioral phentoypes. processes. Reported as: Unveiling how nucleosome repositioning occurs to shed light on genetic diseases …an incomplete formation of overlapping dinucleosome may…

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Virus-driven dietary pathology (2)

See: Virus-driven dietary pathology (1) Virus-mediated archaeal hecatomb in the deep seafloor We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles. Bacteria that cannot find enough food become archaea due to virus-driven energy theft. That fact was placed into the context of “..a possible link between viral infections and chemoautotrophic production in the…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more