RNA methylation

Virus-driven dietary pathology (1)

Viral Trigger for Celiac Disease? A common, seemingly benign human virus can trigger an immune response that leads to celiac disease in a mouse model, researchers show. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease Editor’s summary: Viruses compound dietary pathology Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero). Both reoviruses invoked protective immune…

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Functionally interdependent editing and methylation

Editing and methylation at a single site by functionally interdependent activities …cytosine 32 in the anticodon loop of Trypanosoma brucei tRNAThr is methylated to 3-methylcytosine (m3C) as a pre-requisite for C-to-U deamination. Formation of m3C in vitro requires the presence of both the T. brucei m3C methyltransferase TRM140 and the deaminase ADAT2/3. Once formed, m3C is deaminated to 3-methyluridine (m3U) by the same set of enzymes. ADAT2/3 is a highly mutagenic enzyme4, but we also show that when co-expressed with…

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Cytosis: Biology Content

  Help Me Write Some Biology Content Project Update #5: Cytosis: A Cell Biology Board Game by John Coveyou (Genius Games) Many of you have mentioned that you’d like to have an explanation of the biology behind Cytosis available… and I think that is an AWESOME plan. Every time I’ve taught the game to non-science players in the past, they say gameplay made even more sense (and was so much more enjoyable) when I explained the science as well. This…

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Light-activated feedback loops vs self-organization of ecosystems

John Lieff has been trying to update his ridiculous misrepresentations of biologically-based cause and effect to match the accurate representations we made in a section on molecular epigenetics in our 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior Nothing can stop him, but this will provide the next source for material that he must borrow as if he learned about it somewhere else. Apoptosis analysis guide | Free ebook download Virus-driven energy theft causes apoptosis, which releases…

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Harvard researchers support young earth creationism

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging March 24, 2017 (Science) Reported as: Also reported as:  It’s Happening: Scientists Can Now Reverse DNA Ageing in Mice Excerpts: When we’re born, all of our cells have the ability to repair DNA damage, which we experience constantly through random mutations when our cells divide, or whenever we go out in the sun. But as we get older, our ability to patch up this damage declines, and our cells…

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Sal Giardina: apologetics revisited

March 26, 2017 Sal Giardina wrote: “James, I appreciate your responding to my posts but I would prefer that your input would be related to the content of the post.” My reply: If you do not want people to learn how my claims are linked to yours, please tell me that you intend to continue with apologetics rather the concept of energy as information. Apologetics: … the religious discipline of defending or proving the truth of religious doctrines through systematic…

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Life in your UV light-constrained galaxy

A measurement of the z = 0 UV background from Hα fluorescence Despite the substantial systematic uncertainty that affects our measurement, our work has demonstrated the potential that future MUSE observations have in constraining the intensity of the UVB in the local Universe. This is a report on the Multi Unit Spectroscopic Explorer (MUSE) instrument. The preposterous claim is not supported with experimental evidence that observations made in the context of the instrument somehow constrain the intensity of UV light. That unsupported…

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Where do sex differences come from?

3/22/17 Study identifies brain cells involved in Pavlovian response “The mice learned to associate the new scent with food, just like Pavlov’s dogs,” said Masmanidis, who is also a member of UCLA’s California NanoSystems Institute and Brain Research Institute. “Our next step was to uncover what happens to the Pavlovian response when we silence different groups of cells in the striatum.” Classically conditioned responses link the experience-dependent de novo creation of G protein-coupled receptors from food odors and pheromones to…

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Who will kill the billion dollar baby? Bill Gates or Donald Trump

Bill Gates is set to meet with the President on Monday. [March 20, 2017] Both men know that virus-driven energy theft is the biggest threat humanity has ever faced. The threat arose in the context of wasted US government funding and wasted funding from philanthropists who supported the CRISPR gene-editing technology. For comparison, The Penrose Institute appears to be prepared to establish itself as a refuge for serious scientists who have been cast out of academia for their failure to…

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Thinking about energy is not radical re-thinking

The brain: a radical rethink is needed to understand it …Optogenetics, a technique that uses genetic modification of neurons so that their electrical activity can be controlled with light pulses – can help us to explore their specific contribution to brain function. Optogenetics links the speed of light on contact with water to what is known about all energy-dependent cell type differentiation in all individuals of all living genera. Serious scientists, for example, have linked angstroms to ecosystems in all living…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more