What Your Nose Knows: Sense of Smell and Your Health August 2016

What the Nose Knows May Affect Your Brain Health October 2017

Doty’s research found a strong connection between low scores on a 40-item smell test and damage to this area of the brain. His recent article in The Lancet outlines possible ways that sense of smell and overall brain health could be linked and “may be the genesis of many neurodegenerative diseases.

See: ”Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate?

…a large body of literature suggests that viruses do play a role in Parkinson’s disease and some other neurodegenerative diseases.82 Thus, antibodies or other evidence of viral infection have been found to be higher in the autopsied brains of people with neurodegenerative diseases with the most smell loss (figure 2), relative to the brains of healthy controls. Whether a close relationship exists between smell dysfunction and antibodies or other indicators of viral involvement is unknown. Included are cytomegalovirus in vascular dementia83 and Alzheimer’s disease,84 HSV-6 in Alzheimer’s disease,84 HSV-1 in Alzheimer’s disease,84 and hepatitis C in vascular parkinsonism.85 Additionally, NWS and WSN strains of neurotropic influenza Ao virus have been detected in post-encephalitic parkinsonism.86 A meta-analysis87 found that brains from patients with Alzheimer’s disease were five times more likely to be infected with Chlamydophila pneumoniae than brains from those without Alzheimer’s disease.

Richard L. Doty and others like him fell ~20 years behind the experimental evidence. In 1994, it began to show that pheromones biophysically constrain food energy-dependent viral latency.

See: Daev (1994) [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]

Doty (2010) The Great Pheromone Myth

The Great Pheromone Myth directly challenges ideas about the role chemicals play in mammalian behavior and reproductive processes. It is a must-have reference for biologists, psychologists, neuroscientists, and readers interested in animal behavior, ecology, and evolution.

Daev et al., (2010) The role of social factors in the regulation of stability of the cell genetic machinery in animals

Daev et al., (2014) Chemosignals from isolated females have antimutagenic effect in dividing the cells of bone marrow from male mice of the CBA strain  (cites Kohl et al., 2001 Human pheromones: integrating neuroendocrinology and ethology)

So far as I know, Richard L. Doty has never cited any of my published works. After Robert T. Francoeur and I published “The Scent of Eros: Mysteries of Odor in Human Sexuality (1995), Doty told me and others who were attending the same conferences that he was writing a book about human pheromones. He became the laughing stock of the Association for Chemoreception Sciences when he published and claimed “…that — in contrast to insects — pheromones in mammals do not exist.”

For contrast, see also: Daev et al., (2015) Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems

The development of the cryo-EM technology that led to the 2017 Nobel Prize in Chemistry for the developers now links the life’s works of Eugene Daev and others to refutation of the life’s works by Richard L. Doty and others.Doty  (2017) concludes:

Research is needed to understand how damage to cholinergic and other neurotransmitter circuits occurs in the first place, reflecting issues related to neurogenic precursors, environmental toxins, genetics, epigenetics, and the breakdown of the blood–brain barrier.

Search strategy and selection criteria

I searched PubMed, ISI Web of Science, and Google Scholar for papers published between Jan 1, 1990, and Feb 11, 2017. Multiple search terms were used, including “olfaction”, “neurotransmitters”, “neuromodulators”, “acetylcholine”, “serotonin”, “neurepinephrine”, “dopamine”, “GABA”, “viruses”, “nanoparticles”, “xenobiotics”, “herbicides”, “pesticides”, “interactions”, and the names of all of the diseases outlined in figure 2. I also searched for references within reviews, including reviews that I have authored.

Conclusions based on search strategies like his will continue to prevent others from learning what has been known to all serious scientists about the virus-driven degradation of messenger RNA and how virus-driven energy theft links changes in the microRNA/messenger RNA balance from mutations to all pathology via the sense of smell.

See for comparison:  Cytoplasmic chromatin triggers inflammation in senescence and cancer

Breast tissue, oral and urinary microbiomes in breast cancer

Reported as: Breast cancer: Bacterial deficiency linked with onset

Previous studies have also examined the link between gut microbiota and the development of breast cancer. These studies have suggested that the microbes in the gut may regulate estrogen levels, leading to estrogen-receptor positive breast cancer.

But less attention has been paid to the microbiome residing in the breast tissue of breast cancer patients. Now, researchers break new ground by uncovering the bacterial composition in the breast tissue of cancer patients.

The study found that breast cancer patients had considerably lower levels of a bacterial genus called Methylobacterium.

Methylobacterium is a facultative methylotroph, (meaning it has the ability to grow by reducing carbon compounds with one or more carbon atoms but no carbon-carbon bonds (Chistoserdova et al.2003)), that grows on methylamine, methanol, and C2, C3, and C4 compounds, including the methanol emitted by the stomata of plants.

The virus-driven theft of quantized energy occurs at the level of one-carbon metabolism in the context of Hard Two-Photon Contribution to Elastic Lepton-Proton Scattering Determined by the OLYMPUS Experiment

There is no excuse for Doty’s ignorance or for the ignorance of others who have failed to link olfaction from food odors and what organisms eat to energy-dependent changes in electrons to ecosystems via the physiology of pheromone-controlled reproduction. With the advent of game play “Cytosis” and “Subatomic,” anyone age 10 and over can learn more about biophysically constrained viral latency than Doty and other like him learned during the entirety of their academic careers.

 

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