Conclusion: Serious scientists have a 20 year history of their ability to link energy-dependent changes from electrons to ecosystems via the physiology of pheromone-controlled reproduction in the context of hydrogen-atom transfer in DNA base pairs in solution. This fact links hydrogen-atom transfer in DNA base pairs in solution to the fixation of RNA-mediated amino acid substitutions in hydrophobic supercoiled DNA, which protects all organized genomes from virus-driven entropy.

I reiterate: Hordenine lacks a meta-hydroxyl group compared to dopamine, rendering it unable to form hydrogen bonds to both residues Ser1935.42 and Ser1975.46 as dopamine does42 (Fig. 6).

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How brain develops before birth is tightly controlled by RNA modification

A new field called epitranscriptomics was born out of this knowledge.

See our section on molecular epigenetics from this 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior

The obvious need to link energy-dependent changes from electrons to ecosystems in all living genera via base pairs and RNA-mediated amino acid substitutions was ignored.

But see: This gene editing technique could drastically reduce disease inheritance

My comment:

They used exogenous RNA interference and linked energy-dependent changes in base pairs to all biophysically constrained biodiversity via natural selection for energy-dependent codon optimality (endogenous RNA interference) and the physiology of pheromone-controlled reproduction, which biophysically constrains the virus-driven degradation of messenger RNA that links mutations to all pathology.

This was done at the level of base pair interactions, which link electrons to ecosystems. That fact refutes the pseudoscientific nonsense of neo-Darwinian theories and the nonsense of “Big Bang” cosmology. The gene-editing starts from the creation of energy and entropy is biophysically constrained.

See the other comments:

This is a report on Correction of β-thalassemia mutant by base editor in human embryos.

The food energy-dependent efficient base editing at single-base resolution has been reported in plant, yeast, human cells, mouse zygotes, and human tripronuclear zygotes. The facts were explained in the context of the pheromone-controlled physiology of reproduction, which links the microRNAome of plants to mammals in the context of RNA-mediated DNA repair.

There are more that ~1200 hemoglobin variants that attest to the food energy-dependent ecological adaptation of all human populations that are still found all over the world.

HbVar: A Database of Human Hemoglobin Variants and Thalassemias

There are more than 65,000 published works that link food energy-dependent microRNAs from hemoglobin variants to healthy longevity in humans.

See also: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression

It  became obvious to Schrodinger (1944) that sunlight was the most likely anti-entropic source of all energy-dependent life and obvious to all other serious scientists that the virucidal energy of ultraviolet light was the key to energy-efficient hydrogen-atom transfer in DNA base pairs in solution that differentiates all cell types via amino acid substitutions in supercoiled hydrophobic DNA.

In 1991, Roger Penrose attested to the facts about food energy.

How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?

See also: Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs

…phosphorylation of RNA polymerase II recruits Microprocessor for co-transcriptional processing of non-UGU pri-miRNAs that would otherwise be poorly processed.

Reported as: Range of diseases may result when brain self-regulation goes awry, researchers say

Learn the difference between what “researchers say” and what serious scientist say about energy-dependent cell type differentiation. There is no such thing as self-regulation of the brain. Regulation is food energy-dependent and biophysically constrained by changes in the microRNA/messenger RNA balance.

See for validation: Identification of the Beer Component Hordenine as Food-Derived Dopamine D2 Receptor Agonist by Virtual Screening a 3D Compound Database (with my emphasis)

Although the G protein-biased D2R-agonist hordenine shares structural similarities to the balanced agonist dopamine, receptor–ligand interactions obtained after docking and energy minimisation in presence of a D2R homology model appear to be different. Hordenine lacks a meta-hydroxyl group compared to dopamine, rendering it unable to form hydrogen bonds to both residues Ser1935.42 and Ser1975.46 as dopamine does42 (Fig. 6).

Reported as: The food ingredient hordenine in beer activates the reward centre in the brain

See also:  Cell volume change through water efflux impacts cell stiffness and stem cell fate

Serious scientists have a 20 year history of their ability to link energy-dependent changes from electrons to ecosystems via the physiology of pheromone-controlled reproduction in the context of hydrogen-atom transfer in DNA base pairs in solution. This fact links hydrogen-atom transfer in DNA base pairs in solution to the fixation of RNA-mediated amino acid substitutions in hydrophobic supercoiled DNA, which protects all organized genomes from virus-driven entropy.

I reiterate: Hordenine lacks a meta-hydroxyl group compared to dopamine, rendering it unable to form hydrogen bonds to both residues Ser1935.42 and Ser1975.46 as dopamine does42 (Fig. 6).

 

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