When you next see someone claim that “…there is very little knowledge about the gut microbiome” you may associate that claim with the ignorance touted by neo-Darwinian theorists and compare it to what anyone 10 years-old or older will learn when they play the cell biology game “Cystosis.” A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Moving forward: Food energy is required to build enzymes, hormones and receptors and fend off attacking viruses. The metabolism of food to species-specific pheromones that control the physiology of reproduction in species from microbes to humans is represented in this presentation from 2009 by Eshel Ben-Jacob.

 

At 39:10, he declares that the link from food energy to pheromones and behavior is “epigenetic.”‘

See also: Energy as information and constrained endogenous RNA interference (video)

Published on 15 Feb 2017

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.
The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.
This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.
For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

See for comparison: Preprocessing of emotional visual information in the human piriform cortex

To conclude, our findings support the specific role of the piriform cortex beyond a mere sensory relay up to a higher-order associative brain area. We are the first to demonstrate that the human piriform cortex processes emotional visual information before odor perception. Moreover, we found a common activation pattern in regions of the olfactory network such as piriform cortex, orbitofrontal cortex, amygdala and hippocampus for the subsequent integration of the emotional visual information while processing the actual odor. Matching behavioral results reveal that the emotion of a facial expression influences the valence rating of an odor. Thus, the behavioral observation as well as brain activation data jointly point towards a preprocessed integration of emotional visual information that modulates olfactory processing.

Their ridiculous conclusion, which is based on brain imaging linked to behavior, makes it appear that humans are primarily visual creatures.For comparison, see: Olfaction Warps Visual Time Perception

Our perception of the world builds upon dynamic inputs from multiple senses with different temporal resolutions, and is threaded with the passing of subjective time. How time is extracted from multisensory inputs is scantly known. Utilizing psychophysical testing and electroencephalography, we show in healthy human adults that odors modulate object visibility around critical flicker-fusion frequency (CFF)-the limit at which chromatic flickers become perceived as a stable color-and effectively alter CFF in a congruency-based manner, despite that they afford no clear environmental temporal information. The behavioral gain produced by a congruent relative to an incongruent odor is accompanied by elevated neural oscillatory power around the object’s flicker frequency in the right temporal region ~150-300 ms after object onset, and is not mediated by visual awareness. In parallel, odors bias the subjective duration of visual objects without affecting one’s temporal sensitivity. These findings point to a neuronal network in the right temporal cortex that executes flexible temporal filtering of upstream visual inputs based on olfactory information. Moreover, they collectively indicate that the very process of sensory integration at the stage of object processing twists time perception, hence casting new insights into the neural timing of multisensory events.

They linked what is known about natural information processing in bacteria: Learning from Bacteria about Natural Information Processing to what is known about how Feedback loops link odor and pheromone signaling with reproduction in all living genera.

The feedback loops typically prevent virus-driven energy theft from causing the mutations that have been linked to all pathology by all serious scientists.For comparison, see: Finding what fuels the ‘runaway train’ of autoimmune disease

It has been a long-standing observation in the clinic that autoimmune diseases evolve over time, attacking an ever-expanding array of organs and tissues – a phenomenon known as ‘epitope spreading…

The observation fails to link the virus-driven degradation of messenger RNA to all pathology via energy-dependent changes in the microRNA/messenger RNA balance. See for comparison: microRNA  Items: 1 to 20 of 63935

 
“It’s truly natural selection on a microcosm,” says van der Poel. “Once activated, there are ten different possible colors to represent different B cell clones. Over a week or two, the color diversity begins to shift—eventually one color dominates, representing a single clone winning out.”
 
It’s energy-dependent RNA-mediated autophagy. Activation is energy-dependent and RNA-mediated. Natural selection for energy-dependent codon optimality must be linked from ecological variation to ecological adaptation via the physiology of reproduction in all living genera. These researchers are making unsubstantiated claims about the “evolution” of pathology at a time when all serious scientists know that all pathology is caused by virus-driven energy theft.

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