antibiotic resistance

Achromobacter and killer theories

A pan-genomic approach to understand the basis of host adaptation in Achromobacter  Ecological variation is linked to food energy-dependent biophysically constrained viral latency by the pheromone-controlled physiology of reproduction in species from microbes to humans. For comparison, these authors claim: This study provides strong phylogenetic and pan-genomic bases to motivate further research on Achromobacter, and contributes to the understanding of opportunistic pathogen evolution. Their claim exemplifies how teaching neo-Darwinian theory causes unnecessary suffering and how it may cause the premature…

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Food energy-dependent cell type differentiation (2)

Summary: The concept of “faster-evolving DNA” regions in the context of nucleotide variation in both the 16S and 12S sequences is not consistent with any accurate representation of how the functional structure of supercoiled DNA must be linked from energy-dependent changes in angstroms to ecosystems in all living genera. Conserved molecular mechanisms link the sense of smell in bacteria from the de novo creation of olfactory receptor genes to the physiology of reproduction via the microRNA/messenger RNA balance and Feynman’s…

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Virulence and your UTI

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull Virulence: Take on the role of a virus competing to infect a host cell and replicate your viral components! If you have played this game, you probably know more about virulence than the researchers and journalists…

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Life is energy-dependent task management (2)

See: Life is energy-dependent task management See also: New device detects bacteria and tests for antibiotic resistance When bacteria are caught, the device sends out three different signals to researchers. When bacteria is detected the cantilever’s mass changes, and it bends, explained Thomas Thundat, a professor in the Department of Chemical and Materials Engineering and the Canada Excellence Research Chair in Oil Sands Molecular Engineering. “So this gives us two signals: the mass change and the bending action.” By shining…

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Hypothesis free pseudoscience vs facts (2)

See first: Hypothesis free pseudoscience vs facts (1) Kondrashov and Kondrashov study shows the complexities of evolution at the mitochondrial tRNA level Conclusion: “As compelling as the step-by-step model of Darwinian evolution is, it seems that at least for stems of mt-tRNAs a majority of substitutions involve population dynamics that allow a population to jump over a short but deep valley in fitness.” My comment: As I recall, de Vries defined “mutation” in the content of sudden jumps in morphological…

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Hypothesis free pseudoscience vs facts (1)

Old Earth Creationist (OEC) Peter Berean, thinks I should change the claims in my model of energy-dependent biophysically constrained RNA-mediate protein folding chemistry. He does not like the fact that my model explains all pathology in the context of virus-driven energy theft. If viral latency is not nutrient energy-dependent and controlled by the physiology of reproduction in species from bacteria to humans, I will change my claims. If someone explains what is wrong with my model, I will try to…

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Base pairs, olfaction and RNA thermometers

RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Model vs theory: Progress report!

On June 14, 2013, 1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model and 2) Mutation-Driven Evolution were published with divergent/opposite conclusions. 1) …the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to…

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Ricki Lewis’ Time Machine

Can a Quirky Chromosome Create a Second Human Species? Excerpt 1) The first departure from the common house mouse (Mus musculus) was the “tobacco mouse” (Mus poschiavinus), described in 1869 from specimens trapped in a tobacco factory in Valle di Poschiavo, Switzerland. They had big heads and small, dark bodies. Excerpt 2) I spoke to Bear back in 2004, again for The Scientist (a mechanism for the rapid extinction of a dedicated freelance writer is a change in editor-in-chief). Greg Bear is…

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Cytogenetic approaches link biosystems to ecosystems

Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems (Original Russian Text E.V. Daev, A.V. Dukelskaya, L.V. Barabanova, 2014, published in Ecologicheskaya Genetika, 2014, Vol. 12, No. 2, pp. 3–12.) For comparison see this open access review: Assessing vertebrate biodiversity in a kelp forest ecosystem using environmental DNA The Russian group seemed to me to be ~20 years ahead of the US-based research group. Eugene Daev explained the differences in the approach taken in the two published works.…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more