chromatin

Epigenetic facts vs variable recombination theories

6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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Pseudoscientists hate what science explains! (3)

See also: Pseudoscientists hate what science explains (2) Summary: In addition to germline silencing via information transfer to the physical landscape of supercoiled DNA, multicopy transgene arrays are linked from changes in the microRNA/messenger RNA balance to variation in their somatic expression level. That fact helps to establish the difference between healthy longevity and pathology across generations. Problems with DNA replication can cause epigenetic changes that may be inherited for several generations My summary: The polycomb repressive complex 2, additional…

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De novo gene creation: Ignoring the experimental evidence

Regularly Whiffing Essential Oils Can Retrain Lost Sense of Smell It’s not entirely clear how olfactory training works on a neurological level. Olfactory training links the experience-dependent de novo creation of G protein-coupled receptors to supercoiled DNA. Conserved molecular mechanisms link food odors and pheromones from the innate immune system to the physiology of reproduction. Simply put, autophagy protects all organized genomes from virus-driven entropy and all pathology via the de novo creation of odor receptor genes. See for proof:…

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Polycombic ecological adaptation as a science, not a theory (2)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation Conclusion: … the results here presented indicate that purifying selection is driving not only HBD evolution but also its neighbor pseudogene, HBBP1. In the light of recent advances in the characterization of the β-globin cluster, we propose that the complex patterns of diversity observed in this genomic region arose from distinct functional constraints related with the intricate…

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Biophotonics, glycobiology, quantized biodiversity (2)

From Fertilization to Adult Sexual Behavior (1996) In our section on Molecular epigenetics, we wrote: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility…

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Biophotonics, glycobiology, quantized biodiversity

Historical perspective: From Fertilization to Adult Sexual Behavior Excerpt: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may…

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MicroRNAs and sexual orientation

A neural circuit encoding sexual preference in humans Excerpt: We anticipate the identification of a core neural circuit for sexual preferences to be a starting point for further sophisticated investigations into the neural principles of sexual behavior and particularly of its aberrations. My comment: They link sexual orientation in yeasts to humans but fail to recognize the fact that it is nutrient energy-dependent and pheromone-controlled by RNA methylation, the innate immune system, and supercoiled DNA. 20 years after we published…

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Cancer: Evolution 2.0’s Blind Spot

See also: Hydrogen-atom transfer in DNA base pairs (5) Hydrogen-atom transfer in DNA base pairs (5) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems Excerpt: …methylation of the carbon-5 position of cytosine, which results in differences in 5hmCs, may be the most commonly studied type of nutrient-dependent pheromone-controlled structural and functional eukaryotic modification that results from organizing base pair changes. Team uses internet network theory to decipher the first epigenetic communication network Excerpt: … 5hmC regulates changes in the compaction…

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Let there be anti-entropic light (3)

See also: Let there be anti-entropic light (1) and Let there be anti-entropic light (2) NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program and Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions were reported as: Master switch for brain development found Excerpts: 1)  …the brain is also one of the most complex organs in the body, and very little is understood about the molecular pathways that guide…

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Ignoring top-down causation

Dosage compensation can buffer copy-number variation in wild yeast Introduction Susumu Ohno proposed over 40 years ago that gene duplication could provide a major force in the evolution of new gene functions, by relaxing constraint on gene sequences and allowing one or both gene copies to evolve (Ohno, 1970). The genomic era has largely borne out that hypothesis, and many studies have characterized the outcomes of whole and partial genome amplification (Jaillon et al., 2009). The immediate consequence of duplication…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more