DNA methylation

Epigenetic facts vs variable recombination theories

6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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Evolutionary theories of epigenetic drift

Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data My summary: Outside the context of food energy-dependent biophysically constrained pheromone-controlled viral latency, mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. For example, age-differentially-methylated sites across the genome showed significant MA-consistent increases in heritability with age or significant DS-consistent decreases in heritability. Their results supposedly show that both MA and DS play a role in explaining aging and aging-related changes but…

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Inventing “Transcriptome Trajectory Turning Points”

Summary: They invented the term “Transcriptome Trajectory Turning Points” to prevent others from learning that virus-driven energy theft is the cause of all pathology. Scientists discover genetic timetable of brain’s aging process The biggest reorganisation of genes occurs during young adulthood, peaking around age 26, the team found. These changes affected the same genes that are associated with schizophrenia. The team says this could explain why people with schizophrenia do not show symptoms until young adulthood, even though the genetic…

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Sexual communication signals: New Insights!

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull New insights in the evolution of sexual communication signals Abstract excerpt: Our research focuses on identifying a) the genes underlying sexual signals and responses in both sexes2-4, and b) ecological factors that may cause divergence in…

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Energy-dependent de novo creation and neurogenesis

See also: Tasting light links energy from creation to adaptation Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning reported as: When neurons are ‘born’ impacts olfactory behavior in mice My summary: The de novo creation of different cell types is placed into the context of their energy-dependent birth and the transgenerational epigenetic inheritance of molecular mechanisms that link virus-driven energy theft to all pathology via olfaction, food odors, and human pheromones. See for comparison: Metabolism and neurogenesis …it…

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Light ‘drives’ adaptation; nothing ‘drives’ evolution (2)

See: Light ‘drives’ adaptation; nothing ‘drives’ evolution See also: Who rules the waves? – Viruses might just be bit players in the drama of the seas. Then again, they could be major actors Excerpt (from 1996):  Most consider viruses to be a legion of cripples, sterilised by ultraviolet radiation and rendered impotent by hosts that are largely immune to their threat. But a few researchers take the opposite view. And if they turn out to be right, viruses could radically…

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Base pairs, olfaction and RNA thermometers

RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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RNA methylation

This is a brief history of events that led me to found the domain RNA-mediated.com with some follow-up on the latest news about cell type differentiation In 2012, I attended this minisymposium 006.Transcribing Memories: New Mechanisms of Activity-Regulated Gene Expression and Their Roles in Experience-Dependent Plasticity. Description: Activity-regulated gene transcription is essential for orchestrating the gene expression programs that drive experience-dependent plasticity of neural circuits. Recent studies have not only vastly expanded our understanding of the mechanisms that mediate activity-regulated…

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Countdown to Genetics and Genomics

RNA-mediated physics, chemistry, and molecular epigenetics (5) 5/10/16 Focus: Functional Implications of Human-Specific Changes in Great Ape microRNAs RNA-mediated physics, chemistry, and molecular epigenetics (4) 5/9/16 Focus: Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein RNA-mediated physics, chemistry, and molecular epigenetics (3) 5/9/16 Focus: Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism RNA-mediated physics, chemistry, and molecular epigenetics (2) 5/6/16 Focus: Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton RNA-mediated physics, chemistry,…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more