pre-mRNAs

Eutrophication and phosphorylated biodiversity

In Chinese philosophy, yin and yang (also yin–yang or yin yang, 陰陽 yīnyáng “dark–bright”) describe how seemingly opposite or contrary forces may actually be complementary, interconnected, and interdependent in the natural world, and how they may give rise to each other as they interrelate to one another. Last night I dreamed that someone added color to this symbol and represented it as a spinning disk (in a publication from the Nature publishing group).  The specifics of the dream helped me…

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Lethal virus kills 5 billion people?

Entertaining yourself to death

Summary: Food energy is required for the creation of enzymes that metabolize the food, which links the metabolism to the pheromone-controlled physiology of reproduction in species from microbes to humans via alternative splicings of pre-mRNAs, which are now called microRNAs in more than 65,000 published works. The horrid tradjedy of of yet another preventable death by suicide extends those works to preventing the cause of death of those killed by Stephen Paddock. Vegas gunman transferred $100K, set up cameras at…

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Sexual communication signals: New Insights!

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull New insights in the evolution of sexual communication signals Abstract excerpt: Our research focuses on identifying a) the genes underlying sexual signals and responses in both sexes2-4, and b) ecological factors that may cause divergence in…

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Autophagy: from pre-mRNAs to microRNAs, enhancers, QTLs et al.

Nothing known to serious scientists links anything except energy-dependent changes in chirality to autophagy and biodiversity via RNA-mediated amino acid substitutions that differentiate all cell types in all living genera. That fact forces pseudoscientists to invent new terms to confuse the biologically uninformed masses who were taught to believe in the neo-Darwinian pseudoscientific nonsense of mutation-driven evolution. Autophagy in the liver: functions in health and disease  See the section: Regulation of autophagy by amino acids See for comparison: From Fertilization…

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RNAi: From magic bullet to billion dollar baby

UW-Madison technology enlisted in battle against hepatitis B DNA operates through RNA, and when RNA interference was discovered in 1998, it seemed like a magic bullet that could fight disease by specifically shutting down problematic genes. Before RNA interference was discovered pre-mRNAs were already linked to cell type differentiation in species from microbes to mammals. From Fertilization to Adult Sexual Behavior (1996) Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to…

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GC-rich neo-Darwinian train wreck

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells Excerpt: In this study, we demonstrate direct cellular reprogramming to induced neuronal cells through targeted activation of endogenous genes. Excerpt: Moreover, a recent study demonstrated that reprogramming efficiency can be limited by divergence to a competing cell identity (Treutlein et al., 2016). The molecular mechanisms and practical consequences of these limitations are largely unknown. My comment: They demonstrate what naturally must occur to link…

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Energy-dependent RNA methylation (6)

After I published Nutrient-dependent/pheromone-controlled adaptive evolution: a model, Lynnette Ferguson and Justin O’Sullivan invited me to submit this review of nutritional epigenetics for inclusion in a special issue of the journal “Nutrients.” Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (April 10, 2014) Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes…

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RNA-mediated DNA modifications

A new way to discover DNA modifications Excerpt: Using their approach, which combines bioanalytical chemistry, comparative genomics, and a special type of DNA sequencing, the team has discovered a DNA modification that helps bacteria to protect their genomes from viral infection. My comment: There is one way to link nutrient-dependent microRNA flanking sequences from adhesion proteins to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. It starts with energy-dependent changes in hydrogen-atom transfer in…

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A two-faced protein enables RNA-mediated DNA repair (2)

A two-faced protein enables RNA-mediated DNA repair See also: Abundant contribution of short tandem repeats to gene expression variation in humans (subscription required) Excerpt: …suggesting that STRs have a key role in the evolution of expression. Indeed, several candidate gene studies in humans reported that STR variations modulate gene expression19,33–37 and alternative splicing… Reported as:  Researchers find repetitive DNA provides a hidden layer of functional information Excerpt:  He is calling these variants eSTRs, or expression STRs, to note that they…

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MicroRNAs and the exposome

 MicroRNAs as Potential Signatures of Environmental Exposure or Effect: A Systematic Review Excerpt: Researchers are currently publishing extensive lists of miRNAs that are responsive to environmental exposures and showing their utility as biomarkers of effect. Future research should focus on identifying the molecular mechanism behind miRNA expression changes in response to exposure to determine whether the changes in miRNA expression are merely a symptom of the (patho)physiological processes the organism undergoes after exposure, or whether miRNAs are the drivers responsible…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, mathematicians, statisticians, philosophers and theologians. replaced: Randomness and Divine Providence Supported by the John Templeton...Read more