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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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RNA-mediated radiosensitivity (1)

August 8, 2019
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA interference, Subatomic
No Comments

I posted this to microRNA.pro after resolve of an access issue. It now appears as part two of The Tipping Point (revisited): 90K (2) I will follow up on the link to RNA-mediated radiosensitivity after consideration of Maximum Entropy (Most Likely) Double Helical and Double Logarithmic Spiral Trajectories in Space-Time, which was reported in today’s news as Kepler’s Forgotten Ideas about Symmetry Could Explain Spiral Galaxies Without the Need for Dark Matter 8/8/19 Watch as everything known about biophysically constrained…

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Food energy-as-information, and consciousness

June 22, 2019
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA interference
No Comments

Informational Mode of the Brain Operation and Consciousness as an Informational Related System (6/7/19) Conclusion: consciousness could be fully described and understood in informational terms. In the same issue, the food that organisms eat is linked to human consciousness via natural selection for energy-dependent codon optimality. Codon optimality biophysically constrains viral latency via the physiology of pheromone-controlled reproduction and fixation of RNA-mediated amino acid substitutions. The amino acid substitutions link food energy as information to transgenerational epigenetic inheritance of healthy…

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Trump-hating advocates of vaccines + GMOs (2)

June 7, 2019
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
No Comments

Trump-hating advocates of vaccines + GMOs (1) Conclusion: People who understand the facts about how energy-dependent ecological adaptations to viruses across kingdoms and across generations prevent pathology do not need more theoretical models. For instance, see: Genome-Wide Study Reveals a Novel Regulatory Pathway: Translation Affects mRNA Stability in a Codon-Dependent Manner on June 26, 2019. It is time to force theorists to move forward. Trump-hating advocates of vaccines + GMOs (2) For an attempt to return to the neo-Darwinian pseudoscientific…

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Tasting light links energy from creation to adaptation (2)

April 10, 2019
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA-directed DNA methylation, Subatomic
No Comments

Tasting light links energy from creation to adaptation 12/6/16 Energy as information becomes a signal via its effect on hydrogen-atom transfer in DNA base pairs in solution. The information links the anti-entropic virucidal energy of sunlight to all biophysically constrained cell type differentiation in all living genera via the innate immune system, which links the physiology of reproduction to supercoiled DNA. An inquiry from Best DNA Testing Kits for Ancestry prompted me to update my claims. See their claim: Evolution…

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Virus-driven downsizing of the human brain (6)

March 3, 2019
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed, Subatomic
No Comments

See first: Virus-driven downsizing of the human brain (5) Scientists may need to seriously reconsider the cast-aside hypothesis that pathogens can play a part in diseases such as Alzheimer’s and Parkinson’s. 3/1/19 “Viruses are often ignored in relation to neurodegenerative diseases,” Yale University neurobiologist Anthony van den Pol tells The Scientist. “That’s in part because there’s no clear sign that a virus causes a neurodegenerative disease. But it might.” Some viruses can enter the body through the nose and mouth…

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Virus-driven downsizing of the human brain (5)

March 3, 2019
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference
One Comment

Virus-driven downsizing of the human brain (3) (8/9/16) Virus-driven downsizing of the human brain (4) (4/23/17) Who the heck is James V. Kohl? Thanks for asking. Posted by u/Sphinx_for_hire 3 months ago I’m in biochemistry/toxicology and was reading up on LUCA (aka Last Universal Common Ancestor). While Googling the work of Nick Lane, I stumbled upon the following page absolutely flaying Lane’s and others’ LUCA theories. This guy, James V. Kohl, has many websites in which he writes about human…

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Preprints obfuscate facts (1)

February 25, 2019
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, RNA interference, Subatomic
2 Comments

How many preprints should be published? If someone posts something crazy like vaccines cause autism, I don’t think respectable news outlets will cover it without first discussing the preprint with experts. The light-activated assembly of the microRNA-RNA-peptide nanocomplex and the cure for all cancer was reported by researchers from Israel and discussion by so-called experts followed: See: A cure for cancer? Israeli scientists say they think they found one 1/28/19 The company is now writing patents on specific peptides, which…

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Information Wars started by medical practitioners (1)

August 13, 2018
James Kohl
Autophagy, Ecology, microRNA editing, RNA interference
One Comment

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (Apr 11, 2018) My Summary: The pheromone-controlled physiology of reproduction biophysically constrains viral latency and the transgenerational epigenetic inheritance of healthy longevity in the context of fixation of the EDAR V370A variant. The variant links changes in a single base pair to differences in an amino acid substitution, which links the mouse-to-human model of ecological adaption from microbes to all extant morphological and behavioral biodiversity. See for comparison: Biological Networks: An Introductory…

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Natural models inspire future therapeutics (2)

June 24, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
No Comments

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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Natural models inspire future therapeutics

June 22, 2018
James Kohl
Adaptations, base editing, Cytosis
One Comment

Natural models inspire future therapeutics See: Screaming viruses and Alzheimer’s (1) Screaming viruses and Cancer Screaming Viruses and Alzheimer’s (2) MicroRNA biogenesis, the microRNAome, and your brainome and Reciprocal Interactions Between Gut Microbiota and Host Social Behavior We suggest that investigating these reciprocal interactions can advance our understanding of sociality, from healthy and impaired social cognition to the evolution of specific social behaviours and societal structure. There is no natural model of evolved social behavior. I suggest that all theorists…

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