Welcome to RNA-Mediated

A Research-Driven Blog

by James V. Kohl

Dedicated to the publication and discussion of energy-dependent biologically-based cause and effect.

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Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the energy-dependent  creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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RNA-Mediated

RNA-Mediated

A Paradigm Shift

RNA-mediated amino acid substitutions link the sun’s biological energy to cell type differentiation in all cells of all individuals of all species via RNA-directed DNA methylation, which links what is known about nutritional epigenetics, metabolic networks, and genetic networks in plants and in animals.

Information that links physics, chemistry, and molecular epigenetics via RNA-mediated events, such as the de novo creation of olfactory receptor genes, will be added to encourage discussion of a paradigm shift. That paradigm shift links the balance of viral microRNAs and nutrient-dependent microRNAs via the anti-entropic effects of amino acid substitutions.

Micro RNA

Micro RNA

Linking Science to Health & More

Quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.

Autophagy

Autophagy

Disassembly & Degradation = Recycling!

Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning “self-devouring”[1] and κύτος kýtos, meaning “hollow”[2]) is the natural, regulated, destructive mechanism of the cell that disassembles unnecessary or dysfunctional components.[3]

Autophagy allows the orderly degradation and recycling of cellular components.[4][5] In macroautophagy, targeted cytoplasmic constituents are isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome.[6][7] The autophagosome eventually fuses with lysosomes and the contents are degraded and recycled. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In disease, autophagy has been seen as an adaptive response to stress, which promotes survival, whereas in other cases it appears to promote cell death and morbidity. In the extreme case of starvation, the breakdown of cellular components promotes cellular survival by maintaining cellular energy levels.