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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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God’s microRNA-mediated Creation of genotypes (4)

September 16, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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Non-random distribution of individual genetic diversity along an environmental gradient 6/12/09 links the energy-dependent Creation of ecologically relevant phenotypes to pH-dependent biophysically constrained viral latency across kingdoms via single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs). See also:  T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals 9/16/21 …we report on T cell immunity in infected and vaccinated individuals, identifying CD4+/CD8+ T cell cytokine responses to SARS-CoV-2 and variant peptides… Light-activated carbon…

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God’s microRNA-mediated Creation of genotypes (3)

September 11, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity
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Commentary: Origin and evolution of pathogenic coronaviruses 4/21/20 Both fieldworks and experimental biology are required to understand the viruses concomitantly with predicting or preventing potential outbreaks. On 4/23/20 former President Trump linked God’s Creation of sunlight and humidity to weakened #COVID19 and the end or effective treatment of all virus-driven pathology via RNA interference (#RNAi). See for comparison: Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues  5/25/21 Reported as:…

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God’s microRNA-mediated Creation of genotypes (2)

September 9, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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More than 127,000 indexed published works link God’s energy-dependent Creation of microRNAs to all biodiversity via energy-dependent microRNA-mediated DNA supercoiling . See: microRNA See first: God’s microRNA-mediated Creation of genotypes (1) See also: MiR-125b regulates the differentiation of hair follicles in Fine-wool Sheep and Cashmere goats by targeting MXD4 and FGFR2 9/6/21 If you can’t link this to chromosomal rearrangements and sympatric speciation in species from flies to labradoodles, you haven’t played the STEM toy for ages 14+ “Genotype.” One…

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God’s microRNA-mediated Creation of genotypes (1)

September 8, 2021
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
One Comment

See first: Natural selection for adaptation (10) DNA Logic Circuits for Multiple Tumor Cells Identification Using Intracellular MicroRNA Molecular Bispecific Recognition  9/5/21 The bispecific intracellular miRNA controllable DNA circuit…easily extends to various cell type discrimination by adjusting the [energy-dependent biophysically constrained Creation of] miRNA species… When Fauci claimed it was molecularly impossible to engineer SARS-CoV-2 in the Wuhan lab, the extent of his lies became clear. The fact that he lied before Congress is now clearer. See: Learning noncoding RNA…

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Natural selection for adaptation (10)

September 7, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
One Comment

See: Ignoring light-activated microRNA biogenesis 10/16/18, and compare our section on pre-mRNAs and molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996) to MicroRNAs buffer genetic variation at specific temperatures during embryonic development 10/16/18, which was previously published sans mention of microRNAs as Temporal development of Drosophila embryos is highly robust across a wide temperature range 7/11/18 Changing the term from pre-mRNAs to microRNAs obfuscated food energy-dependent pheromone-regulated genetic processes of cause and effect, but see ~127,000 indexed publications…

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Natural selection for adaptation (9)

September 7, 2021
James Kohl
Adaptations, Diseases & Disorders, Ecology, microRNA editing, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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“Mapping the dynamic transfer functions of eukaryotic gene regulation” 8/31/21 links energy-dependent changes from angstroms to ecosystems via “Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion“ For review see Lynn Zechiedrich‘s group: “Structural diversity of supercoiled DNA” and the representation of God’s Creation of energy-dependent microRNA-mediated biodiversity in: See also: Chemists Know (10/6/14) Remember to start with Feynman’s claims about food energy. Stop the killing spree! Protect yourself sans synthetic mRNA vaccine-induced pathology. See also: Getting Closer to…

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Natural selection for adaptation (8)

September 2, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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Facts about natural selection for adaptation can be compared to theories of Evolution by Gene Duplication (1970) The creation of metazoans, vertebrates and finally mammals from unicellular organisms… required the creation of new gene loci with previously nonexistent functions. The persistent theories of evolution by gene duplication can be compared to facts natural selection for adaptation in the context of God’s Creation of subatomic particles, such as protons and the ATP-dependent creation of RNA, which was required to link the…

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Natural selection for adaptation (7)

August 31, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
One Comment

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome 8/31/21 was reported as: High virus count in the lungs drives COVID-19 deaths 8/31/21 …the study revealed that those who died had on average 50 percent lower production of a type of immune chemical that targets the coronavirus compared with the COVID-19 patients who survived the illness. These customized proteins are part of the body’s adaptive immune system, a subset of cells and chemicals…

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Natural selection for adaptation (6)

August 31, 2021
James Kohl
Adaptations, base editing, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA interference, What's in the News
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I’ve published 3 letters to the editor of a local newspaper, The News Observer, during the past 3 weeks. If this is published on September 1, it may be the end of several multi-part series on the eternal significance of microRNAs, which has been linked to microRNA-mediated population control 7/23/21-8/13/21. See also: Characterizing microRNA-mediated modulation of gene expression noise and its effect on synthetic gene circuits 8/24/21 The results indicated that during the design of MREs in synthetic gene circuits,…

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Natural selection for adaptation (5)

August 26, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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See first: Natural selection for adaptation (4) If you have not yet linked God’s Creation of energy-as-information from the pH-dependent physiology of reproduction to biophysically constrained viral latency and all phenotypes, start with Regulation of MicroRNAs 8/26/21. For comparison, Charles Darwin invented his theory based on no ability to observe biophysically constrained energy-dependent top-down causation at the molecular level. He bred pigeons, which led him to focus on morphology and link the food that finches ate to beak morphology because…

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