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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Pheromones protect us from viruses (2)

March 5, 2021
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, RNA interference
No Comments

Recent advances in the regulation of plant miRNA biogenesis 3/5/21 MicroRNAs (miRNAs) are essential non-coding riboregulators of gene expression in plants and animals… plants use multiple mechanisms to control miRNA accumulation. All of the mechanisms are light-activated and they biophysically constrain viral latency across kingdoms via the physiology of reproduction. See: A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation  7/18/18 …plants alter microRNA (miRNA) biogenesis in response to…

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Pheromones protect us from viruses (1)

March 4, 2021
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
No Comments

Involvement of transposable elements in neurogenesis 3/24/20 appeared in my search for indexed articles that mention microRNA on 3/4/21. There are more than 116,500 others. See: microRNA  MicroRNAs, many of which arise from transposon transcripts, also play an important role in regulating the differentiation of neuronal stem cells. That fact was established in the mid-1990s and was linked From Fertilization to Adult Sexual Behavior (1996) via pre-mRNA-mediated stem cell differentiation across kingdoms in our section on molecular epigenetics. At that time…

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Impeach God or impeach Joe? (1)

March 3, 2021
James Kohl
Adaptations, Diseases & Disorders, Ecology, Light Energy, Model Organisms
No Comments

God’s Creation of energy as information has been linked to biophysically constrained viral latency by all intelligent serious scientists and most intelligent people. Neo-Darwinian theorists, Democrats, liberals, conspiracy theorists, Communists, and other atheists are exceptions. Are they intelligent people? See: Conductance selectivity of Na+ across the K+ channel via Na+ trapped in a tortuous trajectory, which was reported on 3/1/21 as New study challenges ‘established’ mechanism about selectivity of cellular ion channels For a historical perspective on what’s new, see:…

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Impeaching the God of Abraham (9)

March 1, 2021
James Kohl
Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity
No Comments

In “Impeaching the God of Abraham (7) I linked achiral glycine in position 6 of the GnRH decapeptide from peptide synthesis at the origin of life to the patent for naturally occurring light-activated carbon fixation and protonated RNA interference. See also: Regulatory Mechanisms of Vitellogenesis in Insects 1/28/21 …microRNA (miRNA) and nutritional (amino acid/Target of Rapamycin and insulin) pathways interplay with JH and 20E signaling cascades to control insect vitellogenesis. This article is part of the Research Topic Germ Cell…

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Impeaching the God of Abraham (8)

February 28, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, Variations
No Comments

2/22/21 In Case You Missed it. The cure for HIV and all other virus-driven pathology was announced today via an indexed publication found through my daily PubMed search for microRNA. Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters 12/31/20 & indexed on 2/22/21 announced “…a functional cure for HIV.” “The RNA polymerase III promoters H1, 7SK, and U6…” were linked to the cure or the effective treatment of all virus-driven diseases via…

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Impeaching the God of Abraham (10)

February 26, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity
No Comments

sunlight and humidity can weaken the coronavirus — Donald J. Trump 4/23/20 …there’s no medical basis for Trump’s statements about sunlight.  Jonathan Reiner, professor of medicine at The George Washington University Hospital 4/24/20 Former president Trump was absolutely correct. He linked physics and chemistry to molecular biology and healthy longevity via Haplotype-resolved diverse human genomes and integrated analysis of structural variation 2/25/21 Structural variants (SVs) —inversions, deletions, duplications, and insertions ≥50 bp in length—and their breakpoints “…are generally more depleted…

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Impeaching the God of Abraham (7)

February 26, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, microRNA editing, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity
No Comments

MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation 3/9/16 …summarizes the basic biogenesis and mode of actions of miRNAs, recent progress and discoveries of miRNAs in cellular reprogramming, stem cell differentiation and cellular communication, as well as miRNAs in CSCs. MicroRNAs organize intrinsic variation into stem cell states 3/5/20 was linked to prevention of  the virus-driven degradation of messenger RNA in CSCs via the fact that “…naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is…

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Impeaching the God of Abraham (6)

February 26, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed
No Comments

I repeat: “The epigenetic effects of olfactory/pheromonal input calibrate and standardize molecular mechanisms for genetically predisposed receptor-mediated changes in intracellular signaling and stochastic gene expression…” Catalytic Asymmetric Synthesis of the anti‐COVID‐19 Drug Remdesivir 9/1/20 The catalytic asymmetric synthesis of the anti-COVID-19 drug Remdesivir… showed that this DyKAT is a first-order visual kinetic reaction dependent on the catalyst concentration. The unique chiral bicyclic imidazole skeleton and carbamate substituent of the catalyst are both required for the racemization process… The racemization process…

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Impeaching the God of Abraham (5)

February 23, 2021
James Kohl
Adaptations, Alternative Splicings, base editing, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity
No Comments

More than 116,000 indexed published works link sunlight from microRNA biogenesis to biophysically constrained viral latency across kingdoms via the energy-dependent assembly of the microRNA-RNA-peptide nanocomplex. But see: Experts say there’s no medical basis for Trump’s suggestion that sunlight, disinfectants may treat coronavirus 4/24/21 Jonathan Reiner, professor of medicine at The George Washington University Hospital, said there’s no medical basis for Trump’s statements about sunlight. See for comparison: Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction (1986)…

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Impeaching the God of Abraham (4)

February 22, 2021
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity, Subatomic
No Comments

Apple Peel and Flesh Contain Pro-neurogenic Compounds 2/11/21 …mammals evolved with exposure to particular diets… How could theorists continue to miss the obvious connection from light-activated plant growth to food energy, microRNA-mediated viral latency, and healthy longevity? See: MicroRNAs organize intrinsic variation into stem cell states 3/5/20 …naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology. See also: Feedback loops link odor and pheromone signaling with reproduction 11/18/05 Indications that GnRH peptide plays an…

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