Human pheromones: an epigenetic continuum from microbes to mammals
Different noses for different mice and men Review by Andreas Keller (2012). Excerpt: “We are only just beginning to understand the causes and consequences of the unusual genetic and functional variability of large chemosensory receptor gene repertoires in different species.
My comment: I have detailed the causes and the consequences across species from microbes to man. Only by modeling the common molecular biology can cause and effect be understood, so I modeled it!
Personal receptor repertoires: olfaction as a model (reviewed): Excerpt: “…the effective size of the functional human OR repertoire is much higher than the number of intact loci, implying considerable enhancement of the potential of human smell perception diversity.
My comment: Of course the effective size and its genetically predisposed variability is much higher than was claimed, and it is precisely the size required for our species survival as is the effective size of the olfactory receptor repertoire that is required for the survival of other species. If this calibration of the precision did not continue to occur in each species, extinction would occur (as it does when species cannot locate sufficient nutrient chemicals that support pheromone controlled reproduction).
Genomic variation in the vomeronasal receptor gene repertoires of inbred mice (reviewed) Excerpt: “We describe complex patterns of non-random sequence variation that indicate these receptors are under divergent selective pressures that correlate with proposed ligand, phylogeny, chromosomal clustering, and protein domain.”
My comment: What they are saying is that complex patterns of non-random sequence variation result from the combination of genetic predisposition and experience with ligand-specific, de novo receptor gene-mediated beneficial changes in nutrient chemical-dependent behavior that enables adaptive evolution via ecological, social, neurogenic, and socio-cognitive niche construction. Simply put, adaptive evolution via speciation is controlled by the metabolism of nutrient chemicals to pheromones — species specific chemicals that control reproduction in species from microbes to man. For science journalists and laypeople, I’m simply saying that what you eat determines the pheromones that you produce, which determine your social and sexual success. That is what I detailed in Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors Review by Kohl (2012)
Excerpt from the section An epigenetic continuum from microbes to humans: from theory to facts, paragraph 2)
“A gene that codes for the mammalian olfactory receptor, OR7D4, links food odors to human hunger, dietary restraint, and adiposity (Choquette et al., 2012). OR7D4 exemplifies a direct link1 from human social odors to their perception (Keller, Zhuang, Chi, Vosshall, & Matsunami, 2007) and to unconscious affects2 on human behavior associated with human olfactory-visual integration (Zhou, Hou, Zhou, & Chen, 2011); human brain activation associated with sexual preferences (Savic, Heden-Blomqvist, & Berglund, 2009), human learned odor hedonics; and motor function (Boulkroune, Wang, March, Walker, & Jacob, 2007).”
1This ‘direct link’ is between the ligand: androstadienone, and the OR7D4 receptor.
2‘Effect(s)’ and ‘affect(s)’. In context, sensory input effects hormones that affect behavior. An effect of sensory input on hormones can result in behavioral affects/affects on behavior.
—————————————————————————————————————————————
Though the concept is technical, there are people who are familiar with the basic principles of biology and levels of biological organization that are required to link sensory cause to hormones and their behavioral affects in mammals like mice and men. To some, it has now become clear or it will soon become clearer that random mutations theory has no explanatory power when attempts are made to link adaptive evolution via ecological, social, neurogenic, and socio-cognitive niche construction as detailed in my model. Random mutations do not cause adaptive evolution. That’s a ridiculous theory. It is, nevertheless, one that many scientists will continue to incorporate into their works until they know more about cause and effect.
In my model, for comparison, “The concept that is extended is the epigenetic tweaking of immense gene networks in ‘superorganisms’ (Lockett, Kucharski, & Maleszka, 2012) that ‘solve problems through the exchange and the selective cancellation and modification of signals (Bear, 2004, p. 330)’. It is now clearer how an environmental drive probably evolved from that of food ingestion in unicellular organisms to that of socialization in insects. It is also clear that, in mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on sexual behavior in nutrient-dependent, reproductively fit individuals across species of vertebrates.”
It is the change in luteinizing hormone (LH) that epigenetically links olfactory/pheromonal input to the biological core of evolved mammalian behavior via conservation of an evolved gene, cell, tissue, organ, organ system pathway that organizes and activates behavioral reciprocity. The only explanation for adaptive evolution with any across-species explanatory power is found in my details of the epigenetic effects of olfactory/pheromonal input on intracellular signaling and stochastic gene expression, which leads to de novo expression of olfactory receptor genes. Thus, when someone like Andreas Keller says “We are only just beginning to understand the causes and consequences of the unusual genetic and functional variability of large chemosensory receptor gene repertoires in different species.” –The collective, We, should not be used.
Instead, minimally, others could comment on my model, and perhaps tell me what I don’t understand.
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Human Pheromones: The smell of the scientific universe expanding
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Pre-existing genetic variability or random mutations: a matter of priorities and choices
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Human Pheromones and Common Scents: Plants and Perfume
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Adam’s rib: Pheromones and the adaptive evolution of human sexuality
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Human pheromones and your immune system
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People select specific fragrances that suit their individual body odor
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Human Pheromones: extremely technical representation of the concept
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Human Pheromones: but No VNO; No Erox; No Human Pheromone Sciences
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A fallacious leap? Ancestral and derived traits
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Modeling odor processing in microbes, mice, and mankind
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Human Pheromones in Socioaffective Neuroscience & Psychology
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Love is a receptor-mediated event: the pervasive influence of the late Robert L. Moss
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Exercise Alters Epigenetics
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How could antibiotics alleviate symptoms of schizophrenia?
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Pheromones: from microbes to man
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Explaining a good theory
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Researchers Investigate Epigenetic Patterns In Multiple Conditions
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Genes not culture drive humans forward (an antithetical approach)
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Effects of pheromones on menstrual synchrony and a gay man
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The cause of colony collapse could be a message for all of us
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Human Pheromones: 2010 Powerpoint slides and 2011 poster presentation
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Is Love in the Air? Human Pheromones and Axillary Chemistry by George Preti
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Epigentics and the baby connectome
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Another Remembered Present
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Pheromones and food odors add more than just color to your world
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Misrepresentations of biologically based cause and effect:
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Timing is key in the proper wiring of the brain: study
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Cause and effect in biology
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Baiting evolutionary psychologists and others who damn religion
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Show me the science!
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Ethics, aphrodisiacs, and pheromones
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Digit ratio does not predict attractiveness of body odor
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An organizing principle for our sense of smell
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Epigenetics of food odors, nutrition, and pheromones
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Pheromones and falling in love (circa 1974)
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The Demise of Guys
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Trust the science. Don’t trust the hype
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Men and women who stare at goats…
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The Sex Lives of Insects: Part III
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The Sex Lives of Insects (Part II)
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The Sex Lives of Insects
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The epigenetics of food choice and mate choice
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Pheromones and detectable odors
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Epigenetic ‘memory’ key to nature versus nurture
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The “yuck” factor: aversion to social odors?
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Avian ‘Axe effect’ attracts attention of females and males
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Study results: Human pheromones affect women’s behavior
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Human Pheromones and the Biology of Behavior
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Human pheromones: social odors and food odors
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Pheromones and a realistic model of sexual differentiation
3 MIN READ
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Sniffing out your nightlife / Pheromone-infused nightclubs
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Erox rises from the ashes
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Avian recognition of human faces
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Human Pheromones Affect Women's Behavior
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A lesser role for olfaction and pheromones in humans?
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Creating a Myth
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Study results: Human pheromones influence human behavior
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Social selection: genetic contribution of viruses to life on earth
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Natural scent of women linked to increased testosterone and seduction
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Too many good-smelling males is not good
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Pheromones and Physiology: Faculty of 1000: Naturally Selected
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Human pheromones in tears automagically effect testosterone
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Dialogue on pheromones: Avery Gilbert / James V. Kohl
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Mammalian pheromones are not a myth
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Molecular biology and social science theory
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Study Results: Human pheromones increase flirtatious behavior and ratings of attraction
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Results: increased flirtatious behavior and self-reported attraction
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Presentation on Human Pheromones delivered on August 3, 2010
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American and Canadian Mensa Presentation
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The Great Pheromone Myth (opinion/review)
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Welcome to Pheromones.com
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Scent of a woman: Men’s Testosterone Responses to Women's Scent
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Earlier evidence: pheromones influence testosterone in men
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