The end of random mutations theory

By: James V. Kohl | Published on: October 29, 2012

Toward a combinatorial nature of microRNA regulation in human cells
Ohad Balaga, Yitzhak Friedman, Michal Linial

Nucl. Acids Res. (2012) 40(19): 9404-9416

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Excerpt: “Systems biology has identified small miRNA modules that by simultaneous regulation alter a functional module (e.g. EGFR-driven cell-cycle pathway (65)). The hierarchy among miRNAs suggests that some miRNAs act as pathway hubs whereas others are interconnected with transcription factors to provide small functional modules (60).”
My comment: If evolutionary theorists could explain how modulation of mRNA executed in a combinatorial fashion can yield a substantial change in cell phenotype  via control of mRNA and stochastic gene expression by miRNA, they could use the unknown natural mechanisms that might be causal to the change in stochastic gene expression in a logico-/psycho universe to get from one cell type to another type (e.g., from a skin cell to a hormone-secreting cell in the human brain). An under-informed theorist or buffoon could then try to explain how different cell types in different species evolved due to random mutations that somehow enabled our adaptively evolved brain-directed hormone-controlled behaviors.
As an alternative, evolutionary theorists and buffoons could simply accept the facts.
The epigenetic effects of nutrient chemicals calibrate the molecular mechanisms of stochastic gene expression, which is required for individual survival, and the metabolism of nutrient chemicals epigenetically controls species survival via pheromones and the molecular mechanisms of reproduction. Succinctly put, the concept that is extended is the epigenetic tweaking of immense gene networks in superorganisms that solve problems through the exchange and the selective cancellation and modification of signals (as occurs via miRNA and mRNA interactions).
Of course, this means that olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans. But by now most people should already know that and they should also be closer to thinking in terms of adaptive evolution via ecological, social, neurogenic, and socio-cognitive niche construction, which makes sense. Most people should not still be thinking that random mutations cause adaptive evolution. Instead, they should be telling others how ridiculous that theory was.
Thank you for doing your part to advance scientific knowledge and dispense with ridiculous theories.

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