Disorders of development: altered microRNA / messenger RNA balance
(click to enlarge)
My recent poster presentation helps to explain the microRNA / messenger RNA balance in the context of adaptively evolved cell and organism homeostasis. For example, dietary or social stress can result in altered homeostasis, which results in physical and mental disorders. The biological complexity of the model is overwhelming but this 2-minute video representation on the importance of microRNA to physical disorders may prompt neuroscientists to examine my model and my published works in an attempt to learn more about how the altered microRNA / messenger RNA balance results in disorders of brain development and behavior.poster : Main conclusion:
This model of systems biology (“biological embedding”) represents:
Nutrient chemical-dependent and social stress-induced intracellular changes in microRNA and messenger RNA homeostasis
Intermolecular changes in DNA
Experience-dependent stochastic variations in de novo gene expression for odor receptors
The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in GnRH neurosecretory cells of the mammalian brain
The required reciprocity that links gene expression to behavior that alters gene expression (i.e. from genes to behavior and back)
Next steps:
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Results: increased flirtatious behavior and self-reported attraction
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American and Canadian Mensa Presentation
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The Great Pheromone Myth (opinion/review)
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Welcome to Pheromones.com
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Scent of a woman: Men’s Testosterone Responses to Women's Scent
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Earlier evidence: pheromones influence testosterone in men
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(click to enlarge)