Disorders of development: altered microRNA / messenger RNA balance

By: James V. Kohl | Published on: November 23, 2012

My recent poster presentation helps to explain the microRNA / messenger RNA balance in the context of adaptively evolved cell and organism homeostasis. For example, dietary or social stress can result in altered homeostasis, which results in physical and mental disorders. The biological complexity of the model is overwhelming but this 2-minute video representation on the importance of microRNA to physical disorders may prompt neuroscientists to examine my model and my published works in an attempt to learn more about how the altered microRNA / messenger RNA balance results in disorders of brain development and behavior.

From my poster: Main conclusion:

This model of systems biology (“biological embedding”) represents:

  • Nutrient chemical-dependent and social stress-induced intracellular changes in microRNA and messenger RNA homeostasis

  • Intermolecular changes in DNA

  • Experience-dependent stochastic variations in de novo gene expression for odor receptors

  • The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in GnRH neurosecretory cells of the mammalian brain

  • The required reciprocity that links gene expression to behavior that alters gene expression (i.e. from genes to behavior and back)

Next steps:
A model of how mutations might somehow cause adaptive evolution can now be compared to this model of nutrient chemical-dependent non-random adaptive evolution that is controlled by the epigenetic effects of pheromones on reproduction in species from microbes to man.

Notify of
Inline Feedbacks
View all comments

Want more on the same topic?

Swipe/Drag Left and Right To Browse Related Posts: