Genetic Influences on Epigenetically Effected Disease
Science 23 November 2012: Vol. 338 no. 6110 pp. 1016-1017
Human Genetics
Genetic Influences on Disease Remain Hidden by Jocelyn Kaiser
Excerpt: “Some scientists, such as Harry Dietz of Johns Hopkins University in Baltimore, Maryland, suspect that much of the missing heritability lies in gene-gene interactions.”
My comment:
Adaptive evolution occurs via the epigenetic effects of nutrient chemicals on genetically predisposed food acquisition behaviors that alter intracellular signaling and intermolecular changes in DNA. The changes enable the metabolism of the nutrient chemicals to species-specific pheromones that control reproduction by altering nutrient chemical-dependent social behaviors.
This makes it clearer that gene-environment interactions result in sense-driven gene-gene interactions required to achieve cellular and organism-level homeostasis via the microRNA / messenger RNA balance. When perturbed (e.g., stressed) by the epigenetic effects of sensory input, it is that miRNA/mRNA balance that enables de novo gene expression.
If so, one reason we’re seeing less evidence for effects of specific de novo gene expression on disease is because there is first the bottom up epigenetic effect of nutrient chemicals followed by the top-down epigenetic effect of pheromones on adaptive evolution. Looking for a mutated gene that causes uncontrolled intracellular effects and pathology via intermolecular changes that occur via only either a 1)bottom-up, or a 2)top-down approach, seems less likely to reveal the underlying biochemical basis of disease than would examination of how and why nutrient chemical-dependent (e.g., bottom-up) pheromone-controlled (e.g., top-down) reproduction enables de novo gene expression-driven speciation.
After looking at the path from genes to behavior and back, the intracellular and intermolecular dynamics of typical speciation could then be compared to the null effects or deadly effects of mutations and show us why nutrient chemicals and pheromones are part of adaptive evolution and mutations are not. It is because mutations are not part of adaptive evolution that we can be sure olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans in the context of adaptive evolution.
Without that clear evolutionary trail of nutrient chemical-dependent pheromone-controlled reproduction, looking for mutations that cause one thing in vertebrates/mammals/primates or another in invertebrates seems a bit pointless. By the time you get to 4 or 5 million nutrient-chemical and pheromone-controlled DNA switches in the human genome, you will probably have missed something important to homeostasis even if you do find a mutated gene linked to endocrine disruption, toxins, deficient immune systems, or any mental or physical disease processes.
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Human Pheromones: but No VNO; No Erox; No Human Pheromone Sciences
3 MIN READ
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A fallacious leap? Ancestral and derived traits
3 MIN READ
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Modeling odor processing in microbes, mice, and mankind
2 MIN READ
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Human Pheromones in Socioaffective Neuroscience & Psychology
2 MIN READ
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Love is a receptor-mediated event: the pervasive influence of the late Robert L. Moss
3 MIN READ
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Exercise Alters Epigenetics
2 MIN READ
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History of intelligence (550 words)
2 MIN READ
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How could antibiotics alleviate symptoms of schizophrenia?
2 MIN READ
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Creation of different species without physical barriers (Part Two)
2 MIN READ
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Explaining a good theory
< 1 MIN READ
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Researchers Investigate Epigenetic Patterns In Multiple Conditions
< 1 MIN READ
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Genes not culture drive humans forward (an antithetical approach)
< 1 MIN READ
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Creation of different species without physical barriers (Part One)
< 1 MIN READ
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Did viruses make mammals communicate with pheromones?
2 MIN READ
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Human Pheromones: 2010 Powerpoint slides and 2011 poster presentation
2 MIN READ
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Is Love in the Air? Human Pheromones and Axillary Chemistry by George Preti
3 MIN READ
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Another Remembered Present
2 MIN READ
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Pheromones and food odors add more than just color to your world
4 MIN READ
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Misrepresentations of biologically based cause and effect:
3 MIN READ
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The Perversion of Science by Evolutionary Psychologists
5 MIN READ
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Human skull study causes evolutionary headache
< 1 MIN READ
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Timing is key in the proper wiring of the brain: study
2 MIN READ
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Behavioral epigenetics
2 MIN READ
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Cause and effect in biology
< 1 MIN READ
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Baiting evolutionary psychologists and others who damn religion
3 MIN READ
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Show me the science!
5 MIN READ
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Ethics, aphrodisiacs, and pheromones
< 1 MIN READ
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Digit ratio does not predict attractiveness of body odor
< 1 MIN READ
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An organizing principle for our sense of smell
< 1 MIN READ
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Epigenetics of food odors, nutrition, and pheromones
< 1 MIN READ
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Pheromones and falling in love (circa 1974)
< 1 MIN READ
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Trust the science. Don’t trust the hype
2 MIN READ
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Men and women who stare at goats…
2 MIN READ
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The Sex Lives of Insects: Part III
3 MIN READ
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The Sex Lives of Insects (Part II)
3 MIN READ
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The Sex Lives of Insects
< 1 MIN READ
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The epigenetics of food choice and mate choice
< 1 MIN READ
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Pheromones and detectable odors
2 MIN READ
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Epigenetic ‘memory’ key to nature versus nurture
< 1 MIN READ
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Avian ‘Axe effect’ attracts attention of females and males
2 MIN READ
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The Mind’s Eyes: Mindful modeling of brain directed behavior
2 MIN READ
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Study results: Human pheromones affect women’s behavior
< 1 MIN READ
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Human Pheromones and the Biology of Behavior
5 MIN READ
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Human pheromones: social odors and food odors
< 1 MIN READ
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Sniffing out your nightlife / Pheromone-infused nightclubs
< 1 MIN READ
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Erox rises from the ashes
< 1 MIN READ
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Avian recognition of human faces
< 1 MIN READ
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Human Pheromones Affect Women's Behavior
2 MIN READ
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A lesser role for olfaction and pheromones in humans?
1 MIN READ
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Creating a Myth
< 1 MIN READ
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Study results: Human pheromones influence human behavior
2 MIN READ
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Natural scent of women linked to increased testosterone and seduction
< 1 MIN READ
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Too many good-smelling males is not good
< 1 MIN READ
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Human pheromones in tears automagically effect testosterone
2 MIN READ
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Human Pheromones, The Scent of Eros, and Cultural Evolution
< 1 MIN READ
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Dialogue on pheromones: Avery Gilbert / James V. Kohl
2 MIN READ
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Mammalian pheromones are not a myth
3 MIN READ
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Molecular biology and social science theory
2 MIN READ
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Study Results: Human pheromones increase flirtatious behavior and ratings of attraction
2 MIN READ
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Epigenetics, science fiction, and scientific fact
2 MIN READ
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Results: increased flirtatious behavior and self-reported attraction
2 MIN READ
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Presentation on Human Pheromones delivered on August 3, 2010
2 MIN READ
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American and Canadian Mensa Presentation
< 1 MIN READ
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The Great Pheromone Myth (opinion/review)
19 MIN READ
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Welcome to Pheromones.com
< 1 MIN READ
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Scent of a woman: Men’s Testosterone Responses to Women's Scent
< 1 MIN READ
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Earlier evidence: pheromones influence testosterone in men
< 1 MIN READ
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