Are mutations random? (video) The nature of the problem
By: James V. Kohl | Published on: July 27, 2013
Are Mutations Random
July 21, 2013 International Union of Physiological Sciences (IUPS) President’s Lecture by Denis Noble
The introduction by Sir Paul Nurse, starts at 6.00 minutes (below) includes a section on the importance of pulsatile signals.
Professor Noble’s comments begin with comments on random mutations at 5 minutes into his lecture.
Published online before print April 12, 2013, doi: 10.1113/expphysiol.2012.071134
See also Nurse (2008) Life, logic and information. “…if signals are pulsed down a pathway and the changing outputs are monitored, much more complex information can be transmitted. A metaphor here would be the use of the Morse code and the telegraph to communicate messages. Pulses of information sent along the telegraph generate a code for letters and as a consequence sentences can be communicated. This converts the same signalling pathway from a simple on/off switch to a device that can transfer, for example, the works of Shakespeare. It is likely that dynamics has been exploited more generally in the evolution of biological systems for signalling purposes, allowing the communication of more complex information.”
Background: The prenatal migration of gonadotropin-releasing hormone (GnRH) neurosecretory neurons allows nutrients and human pheromones to alter GnRH pulsatility, which modulates the concurrent maturation of the neuroendocrine, reproductive, and central nervous systems, thus influencing the development of ingestive behavior, reproductive sexual behavior, and other behaviors. Methods: This model details how chemical ecology drives adaptive evolution via: (1) ecological niche construction, (2) social niche construction, (3) neurogenic niche construction, and (4) socio-cognitive niche construction. This model exemplifies the epigenetic effects of olfactory/pheromonal conditioning, which alters genetically predisposed, nutrient-dependent, hormone-driven mammalian behavior and choices for pheromones that control reproduction via their effects on luteinizing hormone (LH) and systems biology. Results: Nutrients are metabolized to pheromones that condition behavior in the same way that food odors condition behavior associated with food preferences. The epigenetic effects of olfactory/pheromonal input calibrate and standardize molecular mechanisms for genetically predisposed receptor-mediated changes in intracellular signaling and stochastic gene expression in GnRH neurosecretory neurons of brain tissue. For example, glucose and pheromones alter the hypothalamic secretion of GnRH and LH. A form of GnRH associated with sexual orientation in yeasts links control of the feedback loops and developmental processes required for nutrient acquisition, movement, reproduction, and the diversification of species from microbes to man. Conclusion: An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.
JK: It is now perfectly clear that this statement and any statement or inference like it is WRONG: Random mutations are the substrates upon which directional natural selection acts. Jay R. Feierman: I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement.
The enemies of science 7/28/13 JK (New): Jay, now that it is perfectly clear — in accord with Professor Noble’s presidential address — that you (and others here with doctoral degrees) are wrong about random mutations theory, do you intend to 1) continue to ignore the biological facts; 2) attempt to refute them; or 3) simply continue to propagate the same theories and misrepresentations of Darwin’s works?
Do you think that the late Elaine Morgan was right about the “academic priesthood” that now attempts to suppress any scientific approach that challenges their infallibility as did the priesthood of the Church prior to the time of the Scientific Revolution? Have the enemies of science met and decided “it’s us” or do we need to wait until the next meeting of the International Union of Physiological Sciences (IUPS) to announce a list of enemies? I may offer to chair the nominating committee for the list of enemies depending on your answers and those of any others who are willing to discuss this (or not). Since I am not an enemy of science, I encourage discussion.
Excerpt: “Evolution, then, should be reconsidered in this new light. Living systems are antifragile in that they can do much more than simply respond to the “pressure” of the environment by random mutations followed by selection; they have an in-built property that allows them to find solutions in the face of adversity.”
My comment: This in-built property is evidenced in seemingly ‘futile’ cycles of nutrient-dependent thermodynamic cycles of protein biosynthesis and degradation. The cycles result in fixation of pheromone-controlled nutrient uptake via organism-level thermoregulation in species from microbes to man. Theorists seem to have mistaken what seems to be futile as evidence for mutation-driven evolution, when it is really merely evidence that the theorists have been fooled by in-built “antifragility.”
[…] follow-up on my 7/27/13 blog post Are mutations random? The nature of the problem, addresses the problem I have with dissemination of scientific information via the ISHE’s […]
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RNAi 2002 to AI 2021 (5)
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RNAi 2002 to AI 2021 (4)
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RNAi 2002 to AI 2021 (3)
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RNAi 2002 to AI 2021 (2)
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RNAi 2002 to AI 2021 (1)
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microRNA-mediated cures (10)
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microRNA-mediated cures (9)
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microRNA-mediated cures (8)
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microRNA-mediated cures (7)
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microRNA-mediated cures (6)
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microRNA-mediated cures (5)
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microRNA-mediated cures (4)
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microRNA-mediated cures (3)
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microRNA-mediated cures (2)
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microRNA-mediated cures (1)
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Naturally attenuated viral endemicity (10)
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Naturally attenuated viral endemicity (9)
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Naturally attenuated viral endemicity (8)
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Naturally attenuated viral endemicity (7)
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Naturally attenuated viral endemicity (6)
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Naturally attenuated viral endemicity (5)
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Naturally attenuated viral endemicity (4)
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Naturally attenuated viral endemicity (3)
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Naturally attenuated viral endemicity (2)
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Naturally attenuated viral endemicity (1)
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Orchestrated death of Jews et al., by Egyptians (2)
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Questions to ask if your employer mandates vaccines
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Orchestrated death of Jews et al., by Egyptians (1)
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Orchestrated death: Aeon
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Orchestrated death: Francis S. Collins (2)
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Orchestrated death: J. Michael Bailey (2)
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Orchestrated death: J. Michael Bailey
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Orchestrated death: Kevin J. Mitchell
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Orchestrated death: Philip C. Ball
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Orchestrated death: Sir Paul Nurse
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Orchestrated death: Francis S. Collins
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Orchestrated death:
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God’s microRNA-mediated Creation of genotypes (10)
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God’s microRNA-mediated Creation of genotypes (9)
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God’s microRNA-mediated Creation of genotypes (8)
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God’s microRNA-mediated Creation of genotypes (7)
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God’s microRNA-mediated Creation of genotypes (6)
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God’s microRNA-mediated Creation of genotypes (5)
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God’s microRNA-mediated Creation of genotypes (4)
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God’s microRNA-mediated Creation of genotypes (3)
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God’s microRNA-mediated Creation of genotypes (2)
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God’s microRNA-mediated Creation of genotypes (1)
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Natural selection for adaptation (10)
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Natural selection for adaptation (9)
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Natural selection for adaptation (8)
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Natural selection for adaptation (7)
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Natural selection for adaptation (6)
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Natural selection for adaptation (5)
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Natural selection for adaptation (4)
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Natural selection for adaptation (3)
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Natural selection for adaptation (2)
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Natural selection for adaptation (1)
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Wars caused by metaphors: 1964
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MicroRNA-mediated population control (10)
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MicroRNA-mediated population control (9)
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MicroRNA-mediated population control (8)
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MicroRNA-mediated population control (7)
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MicroRNA-mediated population control (6)
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MicroRNA-mediated population control (5)
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MicroRNA-mediated population control (4)
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MicroRNA-mediated population control (3)
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MicroRNA-mediated population control (2)
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MicroRNA-mediated population control (1)
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microRNA-mediated election cycles (10)
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microRNA-mediated election cycles (9)
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microRNA-mediated election cycles (8)
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microRNA-mediated election cycles (7)
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microRNA-mediated election cycles (6)
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microRNA-mediated election cycles (5)
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microRNA-mediated election cycles (4)
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microRNA-mediated election cycles (3)
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microRNA-mediated election cycles (2)
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microRNA-mediated election cycles (1)
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microRNA-mediated replication cycles (10)
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microRNA-mediated replication cycles (9)
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microRNA-mediated replication cycles (8)
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microRNA-mediated replication cycles (7)
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microRNA-mediated replication cycles (6)
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microRNA-mediated replication timing (5)
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microRNA-mediated replication timing (4)
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microRNA-mediated replication timing (3)
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microRNA-mediated replication timing (2)
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microRNA-mediated replication timing (1)
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Light-activated carbon fixation did not evolve (5)
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The tipping point (revisited): 120K
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Quantum biology vs atheism (2)
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Quantum biology vs atheism (1)
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Quantum Darwinism (10)
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Quantum Darwinism (9)
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Quantum Darwinism (8)
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Quantum Darwinism (7)
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Quantum Darwinism (6)
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Quantum Darwinism (5)
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Quantum Darwinism (4)
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Quantum Darwinism (3)
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Quantum Darwinism (2)
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Quantum Darwinism (1)
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Pheromones protect us from viruses (10)
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Pheromones protect us from viruses (9)
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Pheromones protect us from viruses (8)
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Pheromones protect us from viruses (7)
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Pheromones protect us from viruses (6)
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Pheromones protect us from viruses (5)
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Pheromones protect us from viruses (4)
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Pheromones protect us from viruses (3)
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Defeating disease and Communism (4)
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Defeating disease and Communism (3)
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Defeating Disease and Communism (2)
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Defeating Disease and Communism (1)
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Pheromones protect us from viruses (2)
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Pheromones protect us from viruses (1)
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Impeach God or impeach Joe? (1)
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Impeaching the God of Abraham (9)
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Impeaching the God of Abraham (8)
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Impeaching the God of Abraham (10)
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Impeaching the God of Abraham (7)
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Impeaching the God of Abraham (6)
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Impeaching the God of Abraham (5)
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Impeaching the God of Abraham (4)
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Impeaching the God of Abraham (3)
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Impeaching the God of Abraham (2)
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Impeaching the God of Abraham (1)
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Life or death facts about theories (4)
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The tipping point (revisited): 115K
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Life or death facts about theories (3)
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Life or death facts about theories (2)
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Life or death facts about theories (1)
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Public Heath Fascism vs Creationism (4)
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Public Heath Fascism vs Creationism (3)
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Public Heath Fascism vs Creationism (2)
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Public Heath Fascism vs Creationism (1)
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Racist fascism vs individual liberty (2)
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Creationism, Communism and Corruption (2)
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Creationism, Communism and Corruption (1)
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God’s protection from SARS COV-2 and other viruses (3)
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Expert 13 (1)
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God’s protection from SARS COV-2 and other viruses (2)
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God’s protection from SARS COV-2 and other viruses (1)
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Racist fascism vs individual liberty (1)
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Protonated RNA interference vs stupid theories (10)
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The assassination of intelligence (3)
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The assassination of intelligence (2)
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The assassination of intelligence (1)
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Protonated RNA interference vs stupid theories (9)
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Protonated RNA interference vs stupid theories (8)
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Protonated RNA interference vs stupid theories (7)
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Protonated RNA interference vs stupid theories (6)
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Heliotropic Helioribogenetic Creation of Heliorhodopsin (1)
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Suffering and loss of life by “voting blue” (1)
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UV light, H2O, and epigenetic effects… (4)
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Election day blues for fools who “voted blue” (3)
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Election day blues for fools who “voted blue” (2)
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Election day blues for fools who “voted blue” (1)
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Protonated RNA interference vs stupid theories (5)
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Protonated RNA interference vs stupid theories (4)
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Protonated RNA interference vs stupid theories (3)
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Protonated RNA interference vs stupid theories (2)
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Protonated RNA interference vs stupid theories (1)
[…] follow-up on my 7/27/13 blog post Are mutations random? The nature of the problem, addresses the problem I have with dissemination of scientific information via the ISHE’s […]