Alzheimer's, microRNAs, and olfaction

By: James V. Kohl | Published on: July 30, 2013

A Blood Test for Alzheimer’s? Circulating microRNAs could help doctors diagnose the neurodegenerative disease. By Jef Akst | July 30, 2013
Excerpt: “Testing the blood of 202 people for 140 different microRNAs (miRNAs), a team of researchers at Saarland University, in Germany, identified 12 RNA fragments circulating at consistently different levels in healthy people and patients with Alzheimer’s…”

My comment: In my model, the microRNA/messenger RNA balance is nutrient-dependent and pheromone-controlled. The epigenetic landscape becomes the physical landscape of DNA via the thermodynamics of intercellular signaling and intranuclear interactions. The result is nutrient-stress driven and social stress-driven alternative splicings that may initially benefit organism-level thermoregulation via creation of de novo olfactory receptor genes.
Increasing the number of olfactory receptor genes enables increased nutrient uptake. However, ongoing nutrient stress and/or social stress alter genetic predispositions for Alzheimer’s and other neurodegenerative diseases that until now have manifested themselves first in reduced olfactory acuity.  This suggests to me that the role of the microRNAs might best be assessed in concert with smell testing to arrive more quickly at differential diagnoses in the future.

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