Conserved molecular mechanisms: GnRH

By: James V. Kohl | Published on: July 30, 2013

Your eyes are half a billion years old [but your nose is older than that]
Excerpt: “Why are there many different kinds of eye, including one for insects and crustaceans – and one for vertebrates like us?”
My comment: See also: Kochman (2012)  “During 600 million years of animal evolution, the N and C termini of GnRH have been conserved as functional domains for binding and activating cognate receptors to accomplish its functions.” “It is very surprising and fascinating that the coordinated evolutionary selection of amino acids participating in binding GnRH has resulted in such perfection, that no substitution with a natural amino acid in any position improves binding potency.”  Despite the fact that amino acid substitutions yield differences in species that cannot be accounted for via random mutations theory, some theorists continue to claim we have evolved into primarily visual creatures via mutation-driven evoluton. However, GnRH links olfactory/pheromonal input directly to gene activation in neurosecretory neurons of brain tissue that are the biological core of mammalian reproduction. This puts the relative salience of visual input in humans into the same perspective as in all other animals. We cannot be primarily visual creatures, because there is no animal model that suggests anything other than the primacy of olfaction. “Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans.” Those who insist on using the conservation of molecular mechanisms in development of the eye to tout the relative salience of visual input in humans seem unable to see past the nose on their face, which is 100 million years older than the ‘blind eyes’ they use to look at the world from their tainted perspective of mutation-driven evolution.


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