Comparing divergent model organisms
(click to enlarge)
Excerpt: Overall, our results underscore the importance of comparing divergent model organisms to human to highlight conserved biological principles (and disentangle them from lineage-specific adaptations).
My comment: In the detailed comparisons of divergent model organisms portrayed in Nutrient-dependent/pheromone-controlled adaptive evolution: a model, I underscored what is known about cell type differentiation in species from microbes to man. By placing what is known into the context of nutrient-dependent amino acid substitutions and biodiversity controlled by the metabolism of nutrients to species-specific pheromones, I thought it would be clear that the best approach to understanding how biodiversity arose was to model it. Conclusion: “Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’.”
The model arose from prior published works that clearly linked the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. See for example: Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Conclusion: “Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans…”
Now “…comparing divergent model organisms to human…” continues “…to highlight conserved biological principles…”
These conserved biological principles are obviously the conserved molecular mechanisms of nutrient-dependent pheromone-controlled cell type differentiation we detailed in our 1996 Hormones and Behavior review article in the context of sex differences in cell types. Did anyone who is not an evolutionary theorist think that cell type differentiation occurred differently in different cells of different individuals in different species?
See for review our section on: “Molecular epigenetics” in From Fertilization to Adult Sexual Behavior
“Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.”
See also: Alternative RNA Splicing in Evolution but try to think in terms of how ecological variation leads to ecological adaptations via nutrient-dependent alternative splicing of pre-mRNA. I tried to convey this message yesterday: There are no evolutionary events. There are only epigenetically-effected amino acid substitutions that differentiate cell types and pheromone-controlled cell type differentiation enables biodiversity. There is no model of how biodiversity arises via evolutionary events, because it doesn’t.
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< 1 MIN READ
0
Magic, Miracle, or Molecular Mechanism (2)
8 MIN READ
0
Energy-dependent creation and entropy
4 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics
9 MIN READ
0
MicroRNAs and/or QTLs: Who buried what?
2 MIN READ
0
Wasted Templeton Funding (2)
2 MIN READ
0
Molecular Diagnostics: What is unprotected life (4)
2 MIN READ
0
Genome-gate: Follow the money?
4 MIN READ
0
Molecular Diagnostics: What is unprotected life? (2)
7 MIN READ
0
Molecular Diagnostics: What is unprotected life?
2 MIN READ
0
Half truths support theories without facts
4 MIN READ
0
Creating nutrient-dependent life with enough genes to survive
3 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Ignore the evidence: Rachel Feltman
5 MIN READ
0
Energy-dependent purpose vs teleophobic telorexia
12 MIN READ
0
Stress-linked population-level history dependence
5 MIN READ
0
Energy dependent RNA-mediated immunity (6)
5 MIN READ
0
Do not miss the misrepresentations
2 MIN READ
0
Energy dependent RNA-mediated immunity (5)
4 MIN READ
0
Energy dependent RNA-mediated immunity (4)
6 MIN READ
0
Energy dependent RNA-mediated immunity (3)
8 MIN READ
0
Energy dependent RNA-mediated immunity (2)
10 MIN READ
0
RNA-mediated DNA modifications
5 MIN READ
0
Science vs semantics
4 MIN READ
0
From angstroms to ecosystems and entropy
2 MIN READ
0
Bacteria see the light and they adapt (2)
5 MIN READ
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3 MIN READ
0
Bringing RNA back to epigenetics (20 years later)
11 MIN READ
0
Effects on invertebrate GnRH and affects on primate behavior
6 MIN READ
0
Hybrids: making microbes and Democrats into monkey’s uncles?
11 MIN READ
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (7)
5 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
Will modern human populations adapt to the Zika virus?
5 MIN READ
0
Organic Compounds and the Miracle of Smell and Taste
7 MIN READ
0
Neuroscience Virtual Event vs AAAS Symposium
3 MIN READ
0
Despicable fools?
4 MIN READ
0
Ricki Lewis’ Time Machine
5 MIN READ
0
Virus-perturbed alternative splicings
3 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (5)
10 MIN READ
0
The radical pair mechanism of ecological speciation
3 MIN READ
0
Origin and evolution of the genetic code
2 MIN READ
0
The unoffically uninvited
3 MIN READ
0
Juvenile hormone links atoms to ecosystems
3 MIN READ
0
Finding peace and π in the light of H bond energy (2)
8 MIN READ
0
MicroRNA-mediated RNA epigenetics
2 MIN READ
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
Assumptions prove ignorance
5 MIN READ
0
NORAD: air defense and defense against genomic entropy
7 MIN READ
0
Life history transitions and RNA-mediated survial
2 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
Manufacturing fossil “evidence”
4 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (5)
2 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (2)
< 1 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
MicroRNAs vs Red Queen hypothesis
4 MIN READ
0
Neo-Darwinism vs the neocortex
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Stress-perturbed mitochondrial dysfunction (2)
5 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Virus, transposon and plasmid evolution
< 1 MIN READ
0
Models are not theories (2)
2 MIN READ
0
MicroRNA-encoded behavior
7 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
eQTLs and ecological adaptation
< 1 MIN READ
0
Unraveling the secrets of RNA-mediated events
2 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
Controled Stem Cell Expansion
3 MIN READ
0
Human pheromone deniers: What’s next?
5 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Biophysically constrained or unconstrained?
2 MIN READ
0
Mutated mitochondrial genes vs Supercoiled DNA
2 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs model (3)
2 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
0
Xist-ing on planet Earth
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Non-mainstream scientist shares Nobel prize in Medicine
3 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Metaphysical science vs theory
4 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Theorists have not seen the light (2)
3 MIN READ
0
Gene creation (revisited)
2 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
The creation and activation of GPCRs
4 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Nucleic acids: Stability of DNA/RNA
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (2)
< 1 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Multi-omic analysis features (SNPs, miRNA)
3 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
New anti-entropic microbes
3 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Creating genes and species
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Atomic-resolution of cell type signaling
4 MIN READ
0
Information and communication (2)
6 MIN READ
0
Information and communication
2 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Olfaction & the octopus and human genomes (2)
4 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Thermodynamic constraints did not evolve
3 MIN READ
0
Mammalian-wide interspersed repeats (MIRs)
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Light -induced nucleic acid-mediated gene duplication?
< 1 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
RNA-mediated terms of virus-induced en-deer-ment
2 MIN READ
0
Domestication via a single amino acid substitution
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Riding the wrong direction
3 MIN READ
0
Faithfully repaired DNA
5 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed
2 MIN READ
0
Celebrating independence from ridiculous theories
3 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Unconscious affect (revisited)
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
Virus-driven death by evolutionary theory
3 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
Olfactory perception of genetic information
2 MIN READ
2
Nutrient stress-induced RNA-mediated pathology
< 1 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
What I cannot create I eliminate from discussion
3 MIN READ
0
RNA-mediated development (2)
< 1 MIN READ
0
RNA-mediated development
2 MIN READ
0
Healthy mutants
2 MIN READ
0
Uniquely epigenomic gene regulation
2 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Physicians who practice evolutionary medicine?
3 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Appetite for ingesting theories (raw)
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
One amino acid substitution, genes, and brain activity
3 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Bee-birthed epigenetics and primate cell types
5 MIN READ
0
A lighting requirement for life
11 MIN READ
3
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Bees and primates automagically evolve
3 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Computing via phosphorylation and fixation
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
The microbiome, pharmacogenetics, and privacy
< 1 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
Viruses in gut microbes
4 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
Epigenetics vs the fossil record
4 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Re-inventing a completely new thing
4 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Viruses and cell type differentiation
3 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
The Darwin Code by Greg Bear
13 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory (3)
4 MIN READ
3
Creating nothing but a theory (2)
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Correctly modeling biological energy
2 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Behavior (4): All responses are RNA-mediated in birds
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
Virus-driven origin of life
2 MIN READ
0
RNA-directed gene choice
5 MIN READ
0
Walk towards the light
< 1 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
Is DNA-directed transcription RNA-mediated?
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3 MIN READ
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
Imagining that data historically supports evolutionary theory
7 MIN READ
0
The anti-entropic force of "Nature"
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease (2)
3 MIN READ
0
Atoms to ecosystems is not almost a molecular ecology
3 MIN READ
0
Epigenetic effects of viruses on cellular homeostasis (2)
2 MIN READ
0
The biologically-based origin of the mammalian placenta (2)
6 MIN READ
0
Quantum Superpositions: let there be light
4 MIN READ
0
Physicists: Desperate Acts
16 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
All of "like kind" in the (bigger) family
6 MIN READ
1
Environment epigenetically shapes the immune system
3 MIN READ
0
RNA-protein interactions reveal biophysical to ecological landscapes
2 MIN READ
0
Mutagenesis: Replacing facts with theories
5 MIN READ
0
ISHE's human ethology group
2 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Unified nutritional and molecular mechanisms
9 MIN READ
0
The future of physics predicts no future for evolutionary theory
3 MIN READ
0
Model organisms: the birds and the bees
3 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Atoms to ecosystems: Evolutionary theory vs the coelacanth
6 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Jumping back: Science or Pseudoscience?
6 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
One test of bioenergetic health?
2 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Eliminating correlations from evolutionary ecology
6 MIN READ
0
Are mutations beneficial?
4 MIN READ
0
The key to science: experimental evidence
5 MIN READ
0
Ecological adaptations reported as evolution in insects and mammals
4 MIN READ
0
There’s a model for that!
5 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Nothing new under the sun, except pseudoscientific nonsense
6 MIN READ
0
Making sense of quotes scattered across disciplines
2 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
De novo DNA methylation?
3 MIN READ
0
RNA eclipses the importance of DNA to cell type differentiation
4 MIN READ
0
We need pattern recognition, not proclamations
3 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
Pharmacogenomics
3 MIN READ
0
Sexual differentiation of cell types in plants
2 MIN READ
0
A model of MHC 'evolution'
2 MIN READ
0
From deep time into real time: What evolutionary processes?
10 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
It’s cell type differention, not cell fate determination (2)
3 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
ALPHA GENOMIX
7 MIN READ
2
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Evolutionary theorists and evolutionary theists live under rocks
< 1 MIN READ
0
No understanding of biodiversity
2 MIN READ
0
Understanding physical forces of ecological variation and adaptation
< 1 MIN READ
0
Eliminating evolutionary theory
3 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
2014 and 2004 Nobel Prize in Medicine
3 MIN READ
0
RNA-mediated events: chromosomal rearrangements and genomic rearrangements
2 MIN READ
2
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Unassailable evidence vs assumptions
4 MIN READ
0
Forces of "Nature" limit dissemination of information
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Systems biology and memory disorders
3 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Epigenetically-effected metabolic shifts and ecological adaptations
3 MIN READ
0
Evolving DNA before RNA
4 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
Did our adapted mind evolve? (Revisited)
2 MIN READ
0
De novo gene Creation sans evolution of genes via mutations
4 MIN READ
0
Did our adapted mind evolve?
6 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Miracles are not miracles to evolutionary theorists
2 MIN READ
0
Mathematical model: microRNA and epigenetic regulation
2 MIN READ
0
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Do bacterial proteins evolve?
3 MIN READ
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
Memory of repression and memory of behavior (2)
< 1 MIN READ
0
Memory of repression and memory of behavior
2 MIN READ
0
Quantum physics meets Evolutionary Psychology News
2 MIN READ
0
Nutrient-dependent pheromone-controlled exercise-induced physiques
< 1 MIN READ
0
Watching and waiting for more retractions
2 MIN READ
0
RNA-mediated ecological adaptations of teeth
4 MIN READ
0
A molecular visualizer of worthwhile molecular biology
2 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Genotype, observed phenotype, and distinctly disordered behaviors
3 MIN READ
0
Is the problem an internet echo or Feierman's ethics?
2 MIN READ
0
Behavior (3): All responses are RNA-mediated in bees
3 MIN READ
0
RNA-mediated ecological adaptation is not evolution
2 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4 MIN READ
0
Behavior: The first response is RNA-mediated not genetically-determined
3 MIN READ
0
Mechanisms that are not understood increase clarity
4 MIN READ
2
Pattern recognition and conserved receptors (TAARs)
5 MIN READ
0
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
Evolutionary heritage or ecological adaptation? Racism versus reality
4 MIN READ
0
A relatively young branch of science called epigenetics
4 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
Baby talk: More misrepresentations of ecological adaptations
2 MIN READ
0
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
microRNAs differentiate neuronal cell types
3 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Drunks and Monkeys: Pseudoscientific nonsense
2 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Behavior is receptor-mediated
10 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
Soft atheism: a case for Creation
< 1 MIN READ
0
Nutrition, pheromones and cancer (2)
2 MIN READ
0
Ecologically linked adapted ants and brains
2 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
Cell-type differentiation
2 MIN READ
0
Another powerful refutation of mutation-initiated natural selection
4 MIN READ
0
The new light of chromosomal rearrangements
3 MIN READ
0
Chromosomal rearrangements and ecological adaptations
4 MIN READ
0
The wrong picture of our evolution
4 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Jay R. Feierman
3 MIN READ
0
Don't tell the Creationists
2 MIN READ
0
Alternative splicings (very technical)
2 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0
Your comment is awaiting moderation
2 MIN READ
0
Functional coding variants are not mutations
2 MIN READ
0
Mirror neurons and microRNA: theory vs biological facts
4 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
Alzheimer's, microRNAs, and olfaction
< 1 MIN READ
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
0
Pheromones and cancer
4 MIN READ
0
Nutrient-dependent / pheromone-controlled social structure
2 MIN READ
0
A flawed model: no tripartate synapse in the adult brain
3 MIN READ
0
Evolved development of olfactory systems
2 MIN READ
0
Epistasis as the primary factor in molecular evolution
4 MIN READ
0
Epigenetics and metabolism converge with pheromone production
2 MIN READ
0
Behavioral epigenetics in ecological context
2 MIN READ
0
Epigenetic maintenance of transcription / neuronal migration
2 MIN READ
0
Epigenetics and evolutionary success
< 1 MIN READ
0
Constraints on mutational drift
< 1 MIN READ
0
Epigenetic effects underlie sexual preferences IV
< 1 MIN READ
0
Epigenetic effects underlie sexual preferences III
3 MIN READ
0
Music to our ears and song in birds: a common sense approach
2 MIN READ
0
Thinking about what we know (or not)
2 MIN READ
0
A mathematical model of phenotypic cause, effects on genes, and affects on behavior
2 MIN READ
0
FDA: Just says NO — to ineffective drugs with side effects
< 1 MIN READ
0
Epigenetic effects underlie sexual preferences II
3 MIN READ
0
Is there a model for that?
3 MIN READ
0
One of the clearest examples of epigenetic effects
< 1 MIN READ
0
Epigenetic effects underlie sexual preferences (duh, and food preferences)
2 MIN READ
0
Epigenetic effects on chromatin and regulatation of gene expression (in Archaea?)
2 MIN READ
0
The genetics myth meets the great pheromone myth
2 MIN READ
0
Systems biology met epigenetics two decades ago (not two days ago)
2 MIN READ
0
MicroRNA binds messenger RNA: Adaptive Evolution
< 1 MIN READ
0
A key mutational event? That’s not very likely.
3 MIN READ
0
Mutated genes and accidental intelligence?
< 1 MIN READ
0
Fatal attractions: a fear of pheromones
2 MIN READ
0
Genetic Influences on Epigenetically Effected Disease
2 MIN READ
0
Disorders of development: altered microRNA / messenger RNA balance
< 1 MIN READ
0
Eat like a monkey; act like a monkey
2 MIN READ
0
Human Pheromones: Epigenetic Effects on Hormones and Their Affects on Behavior
3 MIN READ
0
Forum discussions: the most complained about member (866 words)
3 MIN READ
0
Creation vs Evolution: Expression of a newly found gene
2 MIN READ
0
Evolution at work sans random mutations
2 MIN READ
0
Epistasis: Epigenetic effects of nutrient chemicals and their metabolism to pheromones
< 1 MIN READ
0
Sex differences in Alzheimer's and everything else
2 MIN READ
0
The Knowing Nose: Chemical Signals Communicate Human Emotions
< 1 MIN READ
0
The logic of gene regulatory networks
3 MIN READ
0
Human Pheromones: Epigenetic Effects of Odors and Their Affects on Behavior
2 MIN READ
0
Creating new genes (and controlling diversity)
2 MIN READ
0
The end of random mutations theory
2 MIN READ
0
Epigenetic effects of viruses on cellular homeostasis
< 1 MIN READ
0
Diet epigenetically effects development of the primate brain
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Human pheromones determine our social behavior (REJECTED)
3 MIN READ
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Human pheromones: epigenetic effects
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Pheromonemotionally speaking
2 MIN READ
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Human Pheromones: theory vs models
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Human pheromones: another attempt to change the concept
3 MIN READ
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Human pheromones and the fusiform fooled you area for face recognition
3 MIN READ
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The Missing Transgenerational Epigenetic Links
2 MIN READ
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Playing with breasts (e.g, with a new THEORY of why only heterosexual men love them)
3 MIN READ
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Society for Social Neuroscience Presentation scheduled 10/11/12
2 MIN READ
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Epigenetic effects on stochastic gene expression and evolutionary psychology
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The Ghost in Your Genes – BBC Horizon
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Embracing galaxy-wide, cellular, and brain complexity
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“Just-So” stories vs scientific explanations
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Insect to human cognition
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More complicated than 1-2-3
2 MIN READ
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What to do with research results: Warning!
2 MIN READ
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Mischaracterizations of adaptive evolution by psychologists and biologists
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Human pheromones and the epigenetic effects of isolation
2 MIN READ
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Transgenerational epigenetic inheritance of sexual orientation
2 MIN READ
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Natural selection and the behavior of whole organisms
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Natural Selection and the Complexity of the Genome
2 MIN READ
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Human pheromones: an epigenetic continuum from microbes to mammals
3 MIN READ
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Biological facts constrain proponents of random mutations theory
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Pheromones, Reciprocity, and Prosocial Behavior
3 MIN READ
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Is the language of God the god problem? (1530 words)
6 MIN READ
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The Epigenetics of Drug Development and Cholesterol Levels
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Woefully ignorant politicians and popular science
2 MIN READ
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Pheromones and multicellularity
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Epigenetic alterations due to stress
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Epigenetic effects on the evolution of behavior
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Human pheromones, the social brain and simple math computations
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Children’s healthy diets lead to healthier IQ
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Transgenerational epigenetic inheritance via nutrient chemicals
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Human pheromones and IQ via neurogenic and socio-cognitive niche construction
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Human pheromones, nutrition, DNA, epigenetics
2 MIN READ
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Human pheromones are like sugar (and spice)
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Niche construction: ecological, social, neurogenic, and socio-cognitive
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Human Pheromones and Free Will: a response to Gazzaniga
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Human pheromones and multi-level selection
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Where is the love?
3 MIN READ
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Human pheromones and the viruses that make us
2 MIN READ
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A detailed model of physical reality and natural selection (722 words)
3 MIN READ
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Evolution of the nervous system: conserved GnRH
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Is modeling natural selection as a sensing agent reasonable?
3 MIN READ
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Human Pheromones and Comparative Epigenomics
2 MIN READ
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Aging Is Recorded in Our Genes
2 MIN READ
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Human Pheromone Facts and the Out of Africa Theory
3 MIN READ
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Smelling the difference between young and old
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Human pheromones and the visual appeal of other people (Part Four)
3 MIN READ
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A thought experiment
3 MIN READ
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Human pheromones: Olfaction, odor receptors, learning, memory, mood, brains and behavior
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A nutrient chemical and pheromone-dependent neurogenic niche
2 MIN READ
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Human pheromone- and nutrient-dependent brain development and behavior
2 MIN READ
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Human Pheromones: The smell of the scientific universe expanding
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More than speculation: adaptive evolution in species from microbes to man
2 MIN READ
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Human pheromones and your immune system
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Human Pheromones in Socioaffective Neuroscience & Psychology
2 MIN READ
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Pheromones and the “Bruce effect” in wild or domesticated horses and primates
2 MIN READ
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Love is a receptor-mediated event: the pervasive influence of the late Robert L. Moss
3 MIN READ
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They are what they eat, and so are we
2 MIN READ
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Exercise Alters Epigenetics
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How memory works
2 MIN READ
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A Preoccupation With Modesty…
2 MIN READ
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Creation of different species without physical barriers (Part Two)
2 MIN READ
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Pheromones: from microbes to man
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The biology of behavior: Seeing more clearly
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Researchers Investigate Epigenetic Patterns In Multiple Conditions
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Genes not culture drive humans forward (an antithetical approach)
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Effects of pheromones on menstrual synchrony and a gay man
2 MIN READ
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Did viruses make mammals communicate with pheromones?
2 MIN READ
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Do Pheromones Play a Role in Our Sex Lives: Scientific American
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Human Pheromones: 2010 Powerpoint slides and 2011 poster presentation
2 MIN READ
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Epigentics and the baby connectome
2 MIN READ
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Cookbook chemistry: food odors and hormones
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Epigenetics and the connectome
2 MIN READ
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Human pheromones and food odors
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Pheromones and the Evolution of Drug Resistance
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Human pheromones provide clues to personality
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Show me the science!
5 MIN READ
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How pheromones work (in 57 words or more)
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Pheromone-enhanced behavior in sexually inexperienced females
2 MIN READ
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Epigenetic ‘memory’ key to nature versus nurture
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Avian ‘Axe effect’ attracts attention of females and males
2 MIN READ
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Study results: Human pheromones affect women’s behavior
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Human pheromones: social odors and food odors
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Honeybees, food odors, and perfume
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Avian recognition of human faces
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Human Pheromones Affect Women's Behavior
2 MIN READ
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A lesser role for olfaction and pheromones in humans?
1 MIN READ
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Creating a Myth
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Study results: Human pheromones influence human behavior
2 MIN READ
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Pheromones in birds, other mammals, and us
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The great pheromone myth revisited (including biological factors in the development of sexuality)
4 MIN READ
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The great pheromone myth revisited (including biological factors in the development of sexuality)
4 MIN READ
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Social selection: genetic contribution of viruses to life on earth
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Wikipedia comments by James V. Kohl
5 MIN READ
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Excellent new book about pheromones
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Study design| Psychophysics experiment | Perspective on conditioning
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Adrenarche and odor preferences
2 MIN READ
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For ethologists: Observation does not trump molecular biology
2 MIN READ
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Human Pheromones and The Philosophy of Science
2 MIN READ
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Genes, Hormones, and Behavior (for other scientists)
4 MIN READ
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Love at first sight: Selective breeding, pheromones, and Divine intervention
3 MIN READ
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A fundamental attribution error: Love at first sight
3 MIN READ
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Human Pheromones
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Pheromones and olfaction in the birds and the bees: from yeasts to you
2 MIN READ
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Debunking the myth of pheromones
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Tears and fears of pheromones
2 MIN READ
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Exotic Pheromones and Concentrates
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Marketing vs. the truth about human pheromones
2 MIN READ
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Epigenetics, science fiction, and scientific fact
2 MIN READ
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Results: increased flirtatious behavior and self-reported attraction
2 MIN READ
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Is it what he or she sees in you, or is it your pheromones?
2 MIN READ
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Product comparisons and human pheromone sciences
3 MIN READ
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Conditioning of the human pair bond by human pheromones
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Conditioned sexual arousal to odor
2 MIN READ
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Scent signals
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Pheromones and signature mixtures
2 MIN READ
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Comparative biology of pheromonal communication
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Food preferences and mate preferences
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Presentation on Human Pheromones delivered on August 3, 2010
2 MIN READ
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Sold on the human VNO?
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Effects of pheromones attributed to touch (in mice)
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How pheromones work by James V. Kohl
2 MIN READ
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Pheromones of pregnant women effect prolactin in men
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Another book author's comment on "The Great Pheromone Myth"
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An attempt to change the concept
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Luteinizing hormone, sex, and smell (18 years later)
2 MIN READ
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Expanding ENCODE https://www.the-scientist.com/?articles.view/articleNo/40891/title/Expanding-ENCODE/
Latest Encyclopedia of DNA Elements data enable researchers to compare genome regulation across species.
By Jyoti Madhusoodanan | August 27, 2014
Re: “heterochromatin is not the same thing in different organisms, not only in terms of distribution but also in terms of composition.”
Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication reported as: Unraveling mystery in ‘histone code’ shows how gene activity is inherited
Excerpt: “…a single amino acid difference in the structure of histone H3.3 enables it to serve as a kind of memory device for the cell, marking genes that need to remain active…”
My comment: Nutrient-dependent/pheromone-controlled adaptive evolution: a model.
It does no good to explain how the epigenetic landscape becomes the physical landscape of DNA in the organized genomes of species from microbes to man via conserved molecular mechanisms if others cannot understand the link from nutrient-uptake to thermodynamic cycles of protein biosynthesis and degradation that typically leads to amino acid substitutions that stabilize organism-level thermoregulation in the context of an atoms to ecosystems approach to ecological adaptations.
However, if only one other serious scientist would agree that the differences in heterochromatin are nutrient-dependent, others might begin to link nutrient-dependent changes in the microRNA/messenger RNA balance to amino acid substitutions that differentiate all cell types of all individuals in all species via their nutrient-dependent pheromone-controlled reproduction, which leads from ecological variation to biodiversity.
But noooo… other serious scientists won’t do that. Will they?
Who is forcing them to continue to think in terms of evolutionary events, when there has never been such a thing?
And who doesn’t know that Eugene Koonin’s group just changed the ridiculous term “evoluttionary events” to “Genome Dynamics Events” –probably because epigenetically-effected “Genome Dynamics Events” can be linked from ecological variation to nutrient-dependent ecological adaptations in species from microbes to man without the pseudoscientific nonsense of population genetics, mutations, natural selection, and the evolution of biodiversity?