RNA-mediated cell type differentiation and behavior

By: James V. Kohl | Published on: September 29, 2014

Neuroscience Meeting Planner Now Available
The Preliminary Program and Neuroscience Meeting Planner for Neuroscience 2014 are available.
At the 2012 Meeting I learned that the microRNA/messenger RNA balance had emerged during the past decade to be the most likely regulator of all downstream effects on cell type differentiation. That inspired me to focus on what I knew about RNA-mediated events and put what we detailed about them in our 1996 Hormones and Behavior review into the context of a this model.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

Additional examples of nutrient-dependent pheromone-controlled cell type differentiation will be presented at the 2014 meeting. The link from nutrient-dependent RNA-directed DNA methylation to epigenetic effects on cell type differentiation and behavior becomes clearer in these selected presentations.
DNA methylation mediates plasticity of circadian behavior
Epigenetic and transcriptional dysregulation in prodromal Huntington’s disease
A critical period of vulnerability to adolescent stress: epigenetic mediators in mesocortical dopaminergic neurons
Chronic stress induces epigenetic modification to the mPFC, OFC, and HPC of adult rats
Role of DNA methylation in the synaptic and behavioral effects of long-term severe stress
Reversing the behavioral phenotypes in fmr1 KO by the reduction of potassium channel, Kv4.2
Repeated social stress affects DNA methylation of genes associated with CRH/UCN3, arginine-vasopressin and renin-angiotensin systems in adult mouse hippocampus
The long non-coding rna malat-1 is involved in learning and memory formation
Histone methylation and ubiquitination are critical epigenetic regulators of memory reconsolidation
MicroRNA expression in the early postnatal hippocampus of the rat differs between the sexes and is regulated by estradiol and DNA methylation
Gluten and casein-derived opiate peptides alter redox status and produce epigenetic-based differences in gene expression
In utero lead (Pb) exposure and neuron-specific DNA methylation changes in mice
Alternative splicing and DNA methylation in the developing human brain
The DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene are potent diagnostic biomarker in psychiatric disorders
Maternal infection in mice leads different DNA methylation and gene expression between male and female offspring
Methyl supplementation via L-Methionine attenuates addictive-like behaviors in rats and blocks c-Fos activation in the reward circuit following cocaine-primed reinstatement
Prefrontal cortical deletion of DNA methyltransferases Dnmt1 and Dnmt3a induces anhedonia
Gene by environment interaction on post-traumatic stress disorder. Role of genetic and epigenetic differences in FKBP5
Genomic DNA methylation program of a neural stem cells differentiation
Long-lasting alterations in DNA methylome during posttraumatic epileptogenesis
Sex differences of blood in DNA methylation
Additional search strategies include
Also, place your search strategy on GnRH into the context of Feedback loops link odor and pheromone signaling with reproduction For example: “Indications that GnRH peptide plays an important role in the control of sexual behaviors suggest that pheromone effects on these behaviors might also involve GnRH neurons.” p 683.
The link from pheromones to epigenetically effected hormones that affect hormone-organized and hormone activated behavior is represented in the abstract linked here: RNA-sequencing after translating ribosomal affinity purification (TRAP) identifies in vivo gene expression differences in CA3 neurons of mice subjected to early life stress (ELS) 
Here is an abstract excerpt that appears to our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior, and its representations of RNA-mediated sex differences in cell types to the presentations on RNA-directed DNA methylation, and RNA-mediated events that link amino acid substitutions to species-specific sex differences in behavior:
Epigenetic modifications to the DNA imprint early life environment and experience onto the genome. Emerging evidence suggests the default female pattern involves epigenetic repression of the male genome which is emancipated by gonadal steroid inhibition of DNMT activity and subsequent demethylation of key genes, allowing for their expression.

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[…] accurate representations of biophysical constraints and biologically-based facts in RNA-mediated cell type differentiation and behavior and Epigenetic Shaping of Sociosexual Interactions to DS Wilson’s […]

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