RNA-mediated genetic engineering (Part 3)

By: James V. Kohl | Published on: October 4, 2014

RCas9: A programmable RNA editing tool

Excerpt: “The researchers envision a wide range of potential applications for RCas9. For example, an RCas9 tethered to a protein translation initiation factor and targeted to a specific mRNA could essentially act as a designer translation factor to “up-” or “down-” regulate protein synthesis from that mRNA.”
My comment: This “up-” or “down-” regulation of protein synthesis from mRNA occurs naturally in the context of RNA-mediated genetic engineering. Nutrient uptake alters the microRNA/messenger RNA balance and thermodynamic cycles of DNA methylation, protein biosynthesis, and degradation. Protein biosynthesis and degradation are stabilized by nutrient-dependent amino acid substitutions that differentiate all cell types of all individuals of all species.
It is important to again note that RNA molecules function as the central conduit of information transfer in biology. Moving forward, that fact will limit the pseudoscientific nonsense that evoltionary theorists have continued to tout. Clearly, DNA is not the central conduit of information transfer in biology, and information transfer is essential to ecological adaptations. If information about the epigenetic landscape does not lead to accurate representations of cause and effect via RNA-mediated changes to the physical landscape of DNA in organized genomes, ecological variation cannot lead to ecological adaptations manifested in the morphological and behavioral phenotypes of species from microbes to man. Instead, DNA mutations would lead to the evolution of biodiversity and no known molecular mechanisms allow that to happen.


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