RNA eclipses the importance of DNA to cell type differentiation
(click to enlarge)
Excerpt: “…we’re using this approach to identify how the epigenome changes when plants are exposed to challenging environmental conditions, such as drought or high temperature, and how these changes might prime the plants for greater tolerance of subsequent exposures.”My comment: The ‘approach’ is DNA methylation at a time when RNA sequencing has since revealed how the epigenetic landscape becomes the physical landscape of DNA in the organized genomes of species from microbes to man. Simply put, nutrient-dependent RNA-mediated events alter genetic networks and metabolic networks, which is how changes in the microRNA/messenger RNA balance are linked from thermodynamic cycles of protein biosynthesis and degradation to cell type differentiation and biodiversity during the life history transitions of all species.microbes . The molecular biology of cell type differentiation does not change when examined in different species. However, it must be examined in the context of RNA-mediated events before the similarities can be used to explain the difference between theories about evolution and facts about how ecological variation leads to ecological adaptations in microbes and other primates. For example, “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.” (Dobzhansky, 1973 )From Fertilization to Adult Sexual Behavior ” Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.”Alternative RNA Splicing in Evolution. .”…alternative splicing may be the critical source of evolutionary changes differentiating primates and humans from other creatures such as worms and flies with a similar number of genes.”VIDEO VIDEO
Additional resources for refutation of ridiculous theories about mutations and evolution:
There’s a model for that!
Without acknowledging the model, except indirectly by including many of the same works I have reference in my published works, we now see that Ryan Lister has co-authored:
Excerpt: “ De novo DNA methylation is critical for developmental divergence of female larvae towards the honeybee worker caste and is progressive [49,51]. Additionally transition between behavioural castes is associated with changes in DNA methylation and histone modifications [21,40]. However, the precise mechanisms linking the epigenome to control of gene expression, and in particular alternative splicing are not yet understood. In addition, the role of miRNAs and epigenome-modifying compounds such as 10HDA in royal jelly raises the possibility that nutrition may have a significant and direct role in directing patterns of epigenomic control during developmental caste determination. Unlocking these processes will not be without challenges, however the honeybee provides a powerful and tractable model for such studies.My comment: For a broader-based overview of how the model links invertebrates to vertebrates via the conserved molecular mechanisms of cell type differentiation, see:
Excerpt: “The emerging view is that a proper choice of splicing events is regulated by a coordinated action of many components including RNA polymerase II, ribonucleoprotein particles, hundreds of auxiliary proteins, chromatin factors, DNA methylation and histone modifications [46,52]. Elaborate manners of regulation, such as interacting DNA-methylation and histone modification systems, are likely to be the hallmarks of the epigenetic code. The combinatorial utilization of flexible epigenomic modifications, together with gene splicing, post-translation protein modification and RNA editing has ample potential to generate functional diversity from a fixed genotype (Figure 1). In contrast to only 64 codon combinations in the genetic code, the number of possible ‘ciphers’ in the epigenetic code or the level of degeneracy could be many orders of magnitude higher [53]. This high level of degeneracy provides virtually unlimited coding potential to ensure both developmental buffering and flexibility to deal with random external factors.”
Excerpt: “The honeybee already serves as a model organism for studying human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, and diseases of the X chromosome (Honeybee Genome Sequencing Consortium, 2006). Included among these different aspects of eusocial species survival are learning and memory, as well as conditioned responses to sensory stimuli (Maleszka, 2008; Menzel, 1983).”My comment: For a teaser on what is coming next in the context of links from the epigenetic landscape to RNA-directed DNA methylation and RNA-mediated events that differentiate all cell types of all individuals of all species, see:
Excerpt: “RNA, widely known as a cellular messenger that makes proteins and carries out DNA’s instructions to other parts of the cell, is now understood to perform sophisticated chemical reactions and is believed to perform an extraordinary number of other functions, at least some of which are unknown.”My comment: The known functions of RNA in RNA-mediated cell type differentiation via amino acid substitutions have been detailed in blog posts here. They can be found by searching for the term:
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2
0
Open Science: Closed to facts about microRNAs
6
0
Viruses in pathogenic variants disrupt alternative splicings (2)
3
0
Respiration-dependent endogenous RNA interference
4
0
Epigenetically-effected nucleosome repositioning sheds Dobzhansky’s light on evolution
3
0
Sunlight bursts the social bubble of physics and math
3
0
Cytosis: Biology Content
7
0
Light-activated feedback loops vs self-organization of ecosystems
7
0
Johns Hopkins researchers support mutation-driven evolution
< 1
0
Harvard researchers support young earth creationism
< 1
0
Cytosis: A Cell Biology Board Game
< 1
0
Life in your UV light-constrained galaxy
5
0
Food for thought: Penrose v Ellis (3)
4
0
Thinking about energy is not radical re-thinking
6
0
Food for thought: Penrose v Ellis (1)
5
0
Magnussen’s “Faith fools” keep the faith
3
0
Energy-dependent pheromone-controlled entropy (3)
2
0
Proof: Sunlight is energy as information
< 1
0
Energy-dependent pheromone-controlled entropy (2)
6
0
Sunlight: the essence of precision medicine and world peace
6
0
The essence of precision medicine: drug targets or healthy longevity?
4
0
Energy-dependent allelic imbalances, viruses, and pathology
3
0
Biologically uninformed biologists fight back and lose
3
0
Theistic evolutionists fight back and lose (3)
4
0
Theistic evolutionists fight back and lose (2)
4
0
Theistic evolutionists fight back and lose
4
0
Wikipedia refutes theistic evolution
4
0
RNA editing refutes theistic evolution
4
0
Pseudoscientists fail to refute theistic evolution
4
0
Stuart Kauffman refutes theistic evolution
3
0
May the anti-entropic force of sunlight be with you
4
0
Francis S. Collins refutes theistic evolution
6
0
Happy Darwin Day (2017)
4
0
George Church refutes theistic evolution (2)
2
0
George Church refutes theistic evolution
5
0
Natural selection for codon optimality and quantum viruses
5
0
Physicists: Desperate Acts (revisited)
6
0
Energy as information and constrained endogenous RNA interference (3)
4
0
Fighting for virus-driven pathology
5
0
Dobzhansky 1973 and precision medicine (4)
5
0
Dobzhansky 1973 and Precision Medicine (2)
5
0
Science journalists or paid propagandists? (4)
6
0
Dobzhansky 1973 and precision medicine
6
0
Twisted theories and weaponized facts
3
0
Autophagy: from pre-mRNAs to microRNAs, enhancers, QTLs et al.
6
0
Mutations: the “driving force” behind human brain complexity?
6
0
Mutations: the "driving force" behind human brain complexity?
6
0
Critical values expose virus-driven energy theft (2)
4
0
Critical values expose virus-driven energy theft
6
0
Energy-dependent chirality (2)
3
0
Energy-dependent chirality
6
0
Energy-dependent alternative splicings 1996 – 2016 (2)
5
0
Vietnam Veterans and others with glioblastoma
3
0
Energy-dependent sensory maps (1996-2016)
5
0
Energy-dependent oscillating gene networks organize life
4
0
More refutations of neo-Darwinian nonsense
7
0
Re-inventing mutation-driven evolution (2)
4
0
Sudden death indel polymorphism
4
0
Anti-entropic virucidal energy as information
10
0
Bird-brained theorists
< 1
0
Explorers who do not know what is known (2)
6
0
Explorers who do not know what is known
4
0
Energy-dependent natural translational selection
4
0
Energy-dependent de novo creation and neurogenesis (2)
5
0
Energy-dependent de novo creation and neurogenesis
7
0
Theories vs facts about polycombic adaptation
3
0
Tasting light links energy from creation to adaptation
9
0
Politicized science: The demise of RNA-mediated.com?
3
0
Combating evolution: Battlefield medicine vs politicized science
6
0
The futility of The Battlefield FB group
10
0
Metabolic Phenotyping Research
2
0
Happy biophysically constrained Thanksgiving (in the USA)
3
0
De novo gene creation: Ignoring the experimental evidence
7
0
Light, behavior and autophagy, a gender-specific risk factor
4
0
Controlled amino acid treatment of all pathology
4
0
Energy-dependent purifying selection / autophagy (2)
2
0
Energy-dependent purifying selection / autophagy (3)
2
0
Energy-dependent purifying selection / autophagy (4)
2
0
Energy-dependent purifying selection / autophagy (6)
3
0
Energy-dependent purifying selection / autophagy
2
0
Optogenetics: Let there be virucidal light!
2
0
Base pairs, amino acids and phenotypes
10
0
RNA-mediated terrorism
< 1
0
Building delicious base pairs in class. It’s elementary Watson and Crick
3
0
Building delicious base pairs in class. It's elementary Watson and Crick
3
0
RNA-mediated “repurposing” is autophagy
2
0
RNA-mediated "repurposing" is autophagy
2
0
Epigenetics and autophagy vs mutations and evolution (8)
4
0
Energy-dependent maternal-to-zygotic transition
6
1
Virus-driven mutation or amino acid substitution
5
0
Epigenetically effected energy-dependent fluorescence
5
0
Epigenetics and autophagy vs mutations and evolution (7)
3
0
Epigenetics and autophagy vs mutations and evolution (5)
2
0
Epigenetics and autophagy vs mutations and evolution (4)
< 1
0
Epigenetics and autophagy vs mutations and evolution (3)
< 1
0
Epigenetics and autophagy vs mutations and evolution (2)
2
0
Epigenetics and autophagy vs mutations and evolution
< 1
0
From Precis to Proof in 6000 years (3)
2
0
From precis to pre-mRNA and proof of concept in F1, F2, F3
6
0
From Precis to Proof in 6000 years (2)
5
0
From Precis to Proof in 6000 years
9
0
Coulombic interactions facilitate polycombic adaptation
5
0
Top-down adaptation vs bottom-up evolution
6
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution (2)
3
0
Polycombic ecological adaptation as a science, not a theory (2)
12
0
Demoncrats fight polycombic ecological adaptation
4
0
Polycombic ecological adaptation as a science, not a theory
3
0
Biological evolution as a philosophy, not a science
6
0
Attacking Young Earth Creationists
5
0
80 years of causal analysis (1936 – 2016)
11
0
Did evolution autophosphorylate your kinases? (3)
2
1
The natural success of RNAi and failed treatment
7
0
Virus-mediated hecatombic evolution
2
0
Hecatombic evolution via oncocers and oncohistones
9
0
Nutrient-dependent autophagy
3
0
Asking the right questions (2)
3
0
Life is energy-dependent task management (2)
3
0
Life is energy-dependent task management
3
0
Hypothesis free pseudoscience vs facts (4)
5
0
Hypothesis free pseudoscience vs facts (1)
5
0
Chromatin: The structure of DNA (2)
8
0
Chromatin: The structure of DNA (3)
4
0
Hydrogen-atom energy in DNA base pairs
6
0
A working model of “captured” genes
6
0
The Aquatic Ape / Waterside Ape divergence
6
0
Light energy-dependent active motifs
6
0
Light energy-induced base pair changes (2)
4
0
Light energy-induced base pair changes (1)
6
0
DNA repair via junk DNA (1)
5
0
Linking RNA structure to function
3
0
How did the innate immune system evolve?
4
0
The Aquatic Ape: New evidence?
4
0
Plant microRNAs slow virus-driven aging
3
0
Energy-dependent cellular communication
3
0
Conserved biophotonic emissions
7
2
Antithetical conclusions (7)
3
0
Antithetical conclusions (5)
4
0
Antithetical conclusions (4)
3
0
Anthetical conclusions (2)
5
0
Anthetical conclusions
3
0
RNAi: From magic bullet to billion dollar baby
4
0
Co-evolution and co-speciation replace neo-Darwinian nonsense
4
0
Energy-dependent natural fluorescence and bioluminescence
2
0
Pseudoscientists ignore what serious scientists prove
6
0
From angstroms to ecosystems
7
0
Do weak bosons evolve into leptons?
4
0
Biophotonics, glycobiology, quantized biodiversity (2)
19
0
The end of neo-Darwinism
5
0
The Origin of Information (2)
6
0
Did “Nature” kill Steve Jobs? (3)
10
0
Funding the Human Genome Project-Write
2
0
Did “Nature” kill Steve Jobs?
3
0
MicroRNAs and sexual orientation
8
0
RNA methylation, learning, memory and behavior,
< 1
0
Major transition ends use of silly theories
5
0
RNA methylation
2
0
Masters of deception about nature
8
0
The Mind’s Eyes (revisited)
10
0
RNA methylation, behavior, and disease
6
0
Energy-dependent RNA methylation (10)
4
0
Energy-dependent RNA methylation (3)
10
0
Energy-dependent RNA methylation (2)
5
0
Energy-dependent RNA methylation (1)
6
0
War Games: False Flag Terrorism
5
0
Magic, Miracle, or Molecular Mechanism (3)
2
0
Magic, Miracle, or Molecular Mechanism (2)
8
0
Energy-dependent creation and entropy
4
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7
0
RNA-mediated physics, chemistry, and molecular epigenetics
9
0
Wasted Templeton Funding (4)
3
0
RNA splicing, genetic variation, and disease
2
0
Wasted Templeton Funding (3)
2
0
Wasted Templeton Funding (2)
2
0
Molecular Diagnostics: What is unprotected life? (2)
7
0
Ricki Lewis’ Time Machine (4)
8
0
Half truths support theories without facts
4
0
Ricki Lewis’ Time Machine (3)
5
0
Creating nutrient-dependent life with enough genes to survive
3
0
Confusing effects and affects of visual input
2
0
Selective reporting of inferences: examples of pseudoscience
14
0
Energy-dependent purpose vs teleophobic telorexia
12
0
Virus-driven disorder prevention and health promotion
6
0
Stress-linked population-level history dependence
5
0
Jay R. Feierman: twenty years of antagonism
5
0
Do not miss the misrepresentations
2
0
Energy dependent RNA-mediated immunity (5)
4
0
Energy dependent RNA-mediated immunity (4)
6
0
Energy dependent RNA-mediated immunity (3)
8
0
Energy dependent RNA-mediated immunity (2)
10
0
RNA-mediated DNA modifications
5
0
The toxic river of neo-Darwinian pseudoscience
3
0
Science vs semantics
4
0
From angstroms to ecosystems and entropy
2
0
Bacteria see the light and they adapt (2)
5
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands (2)
3
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3
0
Bringing RNA back to epigenetics (20 years later)
11
0
Effects on invertebrate GnRH and affects on primate behavior
6
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA (2)
9
0
Nutrient-dependent RNA-mediated cause and effect
3
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2
0
Bacteria see the light and they adapt
7
0
The Light and Darkness of “Evolution 2.0”
11
0
Models of scientific literacy
3
0
Organic Compounds and the Miracle of Smell and Taste
7
0
Cancer: Evolution 2.0’s Blind Spot
13
0
Despicable fools?
4
0
Ricki Lewis’ Time Machine
5
0
Virus-perturbed alternative splicings
3
0
The radical pair mechanism of ecological speciation
3
0
Brain evolution?
< 1
0
Center stage RNA-mediated events (since 1996)
3
0
Hydrogen-Atom Transfer in DNA Base Pairs (4)
4
0
Blood test links atoms to ecosystems
2
0
A failed theory of cancer: two more decades of pseudoscience
5
0
Teleophobes vs teleophiles: a recent history
2
0
Ecological genomics: teleophobes respond (too late)
10
0
Genes, orchid odors, and pheromones from blonds
5
0
RNA-mediated theory killers (11) (12) (13) (14) (15)
7
0
Finding peace and π in the light of H bond energy (2)
8
0
MicroRNA-mediated RNA epigenetics
2
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3
0
Finding peace and π in the light of H bond energy
5
0
Perry Marshall: too much information for atheist PZ Myers
3
0
Assumptions prove ignorance
5
0
Neo-Darwinian sink testing
2
0
Life history transitions and RNA-mediated survial
2
0
Did Brain Atrophy Evolve?
2
0
Did Dobzhansky see the UV light of creation?
10
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5
0
Does metabolism link beneficial mutations to cancer?
10
0
Hydrogen-Atom Transfer in DNA Base Pairs (3)
3
0
Manufacturing fossil “evidence”
4
0
RNA-mediated theory killers (5)
2
0
RNA-mediated theory killers (3)
7
0
Ecological adaptations you cannot live without
6
0
RNA-mediated regulatory mechanisms link microbes to humans (3)
5
0
Essential pseudoscientific concepts of atheism
3
0
RNA-mediated theory killers (2)
8
0
RNA-mediated theory killers
6
0
Natural cooperation and Evolution 2.0
6
0
A million dollar paradox?
2
0
A two-faced protein enables RNA-mediated DNA repair (4)
6
0
A two-faced protein enables RNA-mediated DNA repair (5)
4
0
A two-faced protein enables RNA-mediated DNA repair (3)
8
0
Teaching the biologically uninformed
3
0
Innovative Neurotechnologies Link Sunlight to Precision Medicine
4
0
Hydrogen-Atom Transfer in DNA Base Pairs
9
0
Neo-Darwinism vs the neocortex
4
0
A two-faced protein enables RNA-mediated DNA repair
2
0
Virally derived RNA molecules and cell types
2
0
Plasma created by sunlight and RNA–mediated epigenetic heredity
2
0
Positive feedback loops and epigenetic traps
2
0
Stress-perturbed mitochondrial dysfunction (2)
5
0
Behavioral Immune System model
4
0
Stress-perturbed mitochondrial dysfunction
4
0
Understanding cell type differentiation
3
0
Let there be anti-entropic light (3)
6
0
Theorists can’t understand biology
6
0
Neuroplasticity
4
0
Sensationalizing no new mechanism
2
0
Cell type differentiation: atoms to ecosystems
2
0
Too complex for the Complex Biological Systems Alliance
4
0
More re-evolved functional structures?
2
0
Receptor methylation controls behavior
2
0
Rediscovering quantum behavior
2
0
From dust to genomic entropy?
3
0
Virus, transposon and plasmid evolution
< 1
0
Conserved molecular mechanisms
< 1
0
Models are not theories (2)
2
0
Models are not theories (1)
2
0
Fossils vs cell types and the brain
3
0
Can veterans and other prisoners escape pseudoscience?
2
0
eQTLs and ecological adaptation
< 1
0
RNA central and RNA-mediated.com
6
0
Ecological speciation. Get it, theorists?
< 1
0
Designing, engineering, and protecting biodiversity
3
0
The virome, microbiome, replisome and supercoiled DNA
2
0
Skip the politics; embrace the facts
5
0
Controled Stem Cell Expansion
3
0
Neo-Darwinian logic is nonsense
3
0
FREE* SAMPLE: Histone modification
4
0
700 million years of evolution?
5
0
Biophysically constrained or unconstrained?
2
0
Mutated mitochondrial genes vs Supercoiled DNA
2
0
RNA-mediated retrotransposon-mediated biodiversity
3
0
Mystery machine vs model (2)
2
0
Mystery machine vs model
2
0
Mystery machine vs medical intelligence
2
0
Xist-ing on planet Earth
2
0
The Current State of Neuroscience
3
0
Cancer: forward and reverse
2
0
Energy and evolution: another opinion?
2
0
Bird watchers and RNAs in cancers
2
0
Supercoiled DNA constrains virus-driven genomic entropy
2
0
Let there be anti-entropic light (2)
4
0
Foundamentals of theory
4
0
Microbes to humans 2015 Nobel Prize
2
0
Non-mainstream scientist shares Nobel prize in Medicine
3
0
Is mainstream science in “Science” pseudoscience?
5
0
Mechanisms of stress: from genes to cancer
9
0
Viruses come alive: Tree of life pseudoscience
6
0
Theorists have not seen the light (2)
3
0
Gene creation (revisited)
2
0
Hijacked light energy and vertebrate pathology
4
0
Theorists have not seen the light
4
0
A 5-10K comparison of design principles to evolution
3
0
Alternative pre-mRNA splicing and ecological adaptation
7
0
Nucleic acids: Stability of DNA/RNA
2
0
Exosomes and the RNA-mediated future of medicine (3)
2
0
Exosomes and the RNA-mediated future of medicine (2)
< 1
0
Exosomes and the RNA-mediated future of medicine
5
0
Multi-omic analysis features (SNPs, miRNA)
3
0
Anti-entropic effects on the origin of life
< 1
0
Somatic hypermutation vs RNA-mediated events
2
0
From fertilization to RNA-mediated events and back
2
0
Phytochemical link from the sun to cell types
2
0
Metabolic competition and cancer
2
0
Natural selection: an anti-entropic force?
2
0
Genome sequencing, cadherins, and quantum consciousness
6
0
“New” quantum biology. Pirating the old
3
0
Creating genes and species
3
0
Cell types, SNVs, CNVs, and chromosomes
3
0
A “new” code enables ecological adaptation
4
0
Thermotolerance and Longevity
57
0
Is life the balance between quantum and classical physics?
3
0
Anti-entropic containment of energy: symbiosis 1.0
5
0
RNA-mediated X chromosome inactivation
3
0
The “great filter” is an epigenetic trap
4
0
Atomic-resolution of cell type signaling
4
0
Information and communication (2)
6
0
Unraveling evolutionary pseudoscience
2
0
Eibi Nevo gets it wrong
3
0
Rs3827760 is Val370Ala and EDARV370A
3
0
From “Blood Music” to Evolution 2.0
5
0
Olfaction & the octopus and human genomes (2)
4
0
Olfaction & the octopus and human genomes
3
0
Protosuns, prebiotic molecules, proteins, and people
4
0
Mammalian-wide interspersed repeats (MIRs)
2
0
Ecological speciation vs revised evolutionary syntheses
6
0
Ecology replaces the extended evolutionary synthesis
4
0
The stability of organized genomes (4)
3
0
The stability of organized genomes (3)
3
0
The stability of organized genomes (2)
5
0
Epimutation.com: a domain of confusion
8
0
Light -induced nucleic acid-mediated gene duplication?
< 1
0
Is the best Chinese research from China?
3
0
The stability of organized genomes
5
0
Viruses, amino acids, and somatic cell types (3)
9
0
Viruses, amino acids, and somatic cell types (2)
5
0
Big Bang Cosmology vs Reality
< 1
0
RNA-mediated terms of virus-induced en-deer-ment
2
0
Domestication via a single amino acid substitution
2
0
Hematopoiesis and practopoiesis
4
0
RNA-mediated morphological AND behavioral phenotypes
2
0
Becoming biologically informed (3)
3
0
Easy editing: Reinventing our RNA world
3
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2
0
Picornaviruses moving between primates (or not)
2
0
Riding the wrong direction
3
0
Decreased phenotypic variation: Faith in Facts
7
1
Faithfully repaired DNA
5
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6
0
MicroRNA controlled growth and brain development
7
0
MicroRNA – controlled ecological adaptations
5
0
Becoming biologically informed
2
0
Celebrating independence from ridiculous theories
3
0
“New” epigenetic mechanism for lifelong learning?
3
0
The sum of our RNA-mediated parts
2
0
microRNAs and memory: Why trust a theory?
2
0
Protein folding and Google page rank
2
0
Iron, ferritin, thyroxine
2
0
“Evolution” of sex differences?
2
0
RNA-mediated cell type differentiation: Honeybee
< 1
0
Nutrient stress-induced RNA-mediated pathology
< 1
0
Amino acid substitutions are not mutations
2
0
RNA-mediated events from A to Z
2
0
What I cannot create I eliminate from discussion
3
0
RNA-mediated development
2
0
Creating and maintaining the human virome
2
0
Healthy mutants
2
0
Uniquely epigenomic gene regulation
2
0
MicroRNAs and inappropriate functions
2
0
Rejecting pseudoscientific nonsense
6
1
Living the life that randomness created? (Sarcasm alert)
3
0
30 years of theoretical nonsense
3
0
microRNAs, glycosylation, and genomes
4
0
Unknown mechanisms and conclusions
2
0
Alternative splicings: epigenetics meets pharmacogenomics
4
0
Epigenetic regulation of aging by glycine and GnRH
5
0
Physicians who practice evolutionary medicine?
3
0
Pattern recognition: biogeochemical structure and function
5
0
Viruses and the human-like microbiome
3
0
Informing the biologically uninformed
< 1
0
Tweaking the story to fit the theory
5
0
Appetite for ingesting theories (raw)
< 1
0
I forgot. How do mutations cause evolution?
4
0
One amino acid substitution, genes, and brain activity
3
0
Batch effect vs epigenetic effects
3
0
Gene expression, immortality, and cancer
6
0
Missing a fact: microRNAs are genomic biomarkers
4
1
Bee-birthed epigenetics and primate cell types
5
0
A lighting requirement for life
11
3
Scientists lose. A sci-fi author gains credibility
2
0
Vitamin B3 and DNA repair
4
0
Bees and primates automagically evolve
3
0
Ignoring systems complexity (it’s too complicated)
3
0
Five years of Ferguson
2
0
Computing via phosphorylation and fixation
3
0
Virus-driven cancer treatment and prevention
2
0
The microbiome, pharmacogenetics, and privacy
< 1
0
A special issue on nutritional epigenetics
5
0
Retinoic acid + one receptor regulate the genome
3
0
Epigenetics: microRNAs effect an integrative pathway
4
0
Protein isoforms do not evolve
3
0
Tissue type variation and expression of genes
< 1
0
From gut bacteria to breast milk and back
5
0
Chance mutations — not natural selection
5
0
Viruses in gut microbes
4
0
Physics, chemistry, light, and life
2
0
Finding odor and taste receptors everywhere
6
0
Linking the origin of birds to dinosaurs
< 1
0
An epigenetic mark links algae, worms, and flies
2
0
Effect and affect of a single base-pair change
4
0
Tet3 regulation of nutrient-dependent cell type differentiation
4
0
Thermodynamics and protein folding landscapes
2
0
RNA-mediated silencing of a chromosome
3
0
Viruses, proteins, and gut metagenomes do not evolve
< 1
0
Pathology constrains X-linked evolution
2
0
Feedback loops link insects to human brains
2
0
Viruses and cell type differentiation
3
0
RNA-mediated cell types and precision medicine
5
0
DNA Methylation and organized genomes (2)
10
0
DNA Methylation and organized genomes
7
0
Misunderstanding cancer
7
0
Amino acid-dependent cell type differentiation
8
0
Nutrient-dependent RNA interference (2)
4
0
The Darwin Code by Greg Bear
13
0
Nutrient-dependent RNA interference
4
0
Mutisensory integration: watching the paradigm shift
12
0
Origin of life and cancer (1,2,3)
2
0
A genetic variant refutes neo-Darwinism
6
0
MicroRNAs and invasive phenotypes
< 1
0
Silencing genes and serious scientists
3
0
The miRNA/mRNA balance: a suboptimal strategy?
2
0
Nutrient-dependent microRNAs control cell types
6
0
Deeply ingrained thoughts
< 1
0
Graphic misrepresentations of ecological adaptation
2
0
Too many targets for theories
3
0
Methylation maintains cell type differences (2)
2
0
Methylation maintains cell type differences
3
0
Creating nothing but a theory (3)
4
3
Creating nothing but a theory (2)
4
0
Creating nothing but a theory
4
0
Viruses and ecologically adapted animals
2
0
2 genes in 2 species (too expensive and too insignificant)
11
0
The quantum / classical RNA-mediated ‘tipping point’
3
0
Epigenetic effects of soil bacteria on plants
< 1
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4
0
Quantum correlations/pseudoscience
3
0
Anti-entropic solar energy
5
0
Mimicking claims and ignoring facts
4
0
Correctly modeling life on this planet
3
0
Correctly modeling ecological adaptation
4
0
Behavior (4): All responses are RNA-mediated in birds
4
0
Questions about life’s diversity
21
0
UV-light mutations and gene loss (not gain)
5
0
Virus-driven origin of life
2
0
Luis P. Villarreal tells it like it is
3
0
RNA-directed gene choice
5
0
Walk towards the light
< 1
0
Two types of microRNA are not double agents
2
0
Epigenetics Skeptism
5
0
Is DNA-directed transcription RNA-mediated?
2
0
Assembling yourself: Molecular self / other recognition
4
0
What about birds?
5
0
Virus-driven cell type differentiation
2
0
RNA directed DNA methylation and cell types
4
0
Implicating microRNAs in cancer
2
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2
0
Reverse phosphorylation
7
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3
0
From 3-D to epigenetically-effected 4-D genome make-up
5
0
Let there be anti-entropic light (1)
11
0
An epigenetic trap (the prequel)
5
0
Imagining that data historically supports evolutionary theory
7
0
Atheism: Arrogant, useless, and divisive ignorance
7
0
The anti-entropic force of "Nature"
2
0
Nutritional epigenetics, exercise, and immune system integrity
4
0
What if Darwin was not still dead?
2
0
Military combat training to fight disease (2)
3
0
Military combat training to fight disease
3
0
Theoretical physics and molecular biology
5
0
Atoms to ecosystems is not almost a molecular ecology
3
0
Epigenetic effects of viruses on cellular homeostasis (2)
2
0
RNA-mediated epigenetic modification via DNA-methylation
4
0
Quantum physics, quantum biology, and quantum consciousness
4
0
How fast can evolutionary theory be changed?
5
0
Biological energy and a microbiome model of a light-driven time machine
3
0
The biologically-based origin of the mammalian placenta (2)
6
0
Quantum Superpositions: let there be light
4
0
Are viruses microRNAs? (2)
5
0
Are viruses microRNAs?
3
0
Sneaking up from behind (2)
3
0
Sneaking up from behind
4
0
Quantum entanglement, mass, and biomass
4
0
Physicists: Desperate Acts
16
0
An epigenetic trap (the sequel)
10
0
Mute points: most are afraid to mention them
6
0
All of “like kind” (Part 2)
2
0
All of "like kind" in the (bigger) family
6
1
Environment epigenetically shapes the immune system
3
0
Beneficial microbes kill beneficial mutations
4
0
Constrained evolution is ecological adaptation
5
0
A single amino acid substitution differentiates cell types of E. coli
3
0
Unconstrained evolutionary innovability
4
0
RNA-protein interactions reveal biophysical to ecological landscapes
2
0
Mutagenesis: Replacing facts with theories
5
0
ISHE's human ethology group
2
0
Amino acid homeostasis for a Happy New Year!
6
0
Understanding cell type differentiation
3
0
From Hydra to humans vs a Lakatosian research program
4
0
Unified nutritional and molecular mechanisms
9
0
Removing natural selection; reshaping the horse; adjusting evolutionary theory
4
0
Communication, not mutations
2
0
Models by evolutionary biologists are not models
2
0
The future of physics predicts no future for evolutionary theory
3
0
Model organisms: the birds and the bees
3
0
Chemical ecology and RNA-mediated control of DNA loops
< 1
0
Atoms to ecosystems: Evolutionary theory vs the coelacanth
6
0
Jumping back: Science or Pseudoscience? (2)
2
0
Jumping back: Science or Pseudoscience?
6
0
Single-cell level assay of protein biosynthesis and degradation
2
0
Glycine and GnRH: Am I being pedantic?
4
0
Extensive molecular evidence vs ridiculous theories
2
0
Dual genomes: exposing the evolution industry
5
0
One test of bioenergetic health?
2
0
Meaningful dialogue, anonymous fools and idiot minions
4
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3
0
RNA-mediated events and "The Theory of Everything"
4
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2
0
Thermodynamic constraints and ecological adaptations sans evolution
6
0
Eliminating correlations from evolutionary ecology
6
0
RNA-mediated species specificity
2
0
Are mutations beneficial?
4
0
The key to science: experimental evidence
5
0
Ecological adaptations reported as evolution in insects and mammals
4
0
There’s a model for that!
5
0
Biologists puzzled by evolved RNAs and decaying DNA
6
0
SNPs and millions of small variations in the human genome
3
0
More than a bag of chemicals?
2
0
Achiral GnRH: no prophesy, just prediction
9
0
Nothing new under the sun, except pseudoscientific nonsense
6
0
Making sense of quotes scattered across disciplines
2
0
Intelligent viruses and cancers?
10
0
Complex behaviors of cell types in cancer
6
0
De novo DNA methylation?
3
0
We need pattern recognition, not proclamations
3
0
We need pattern recognition, not a prologue
6
0
Pharmacogenomics
3
0
Sexual differentiation of cell types in plants
2
0
A model of MHC 'evolution'
2
0
From deep time into real time: What evolutionary processes?
10
0
In theory, or supported by experimental evidence?
5
0
It’s cell type differention, not cell fate determination (2)
3
0
Are evolutionary theorists 'nob ends'?
5
2
ALPHA GENOMIX
7
2
No excuses: Creation and the meaning of organismal complexity
7
0
Nutrient-dependent gene duplication in plants (but not animals?)
4
0
Evolutionary theorists justify fear of the Ebola viruses
2
0
Evolutionary theorists and evolutionary theists live under rocks
< 1
0
No understanding of biodiversity
2
0
Understanding physical forces of ecological variation and adaptation
< 1
0
Eliminating evolutionary theory
3
0
Behavioral ecology: please continue to believe in our fantasies
3
0
2014 and 2004 Nobel Prize in Medicine
3
0
RNA-mediated events: chromosomal rearrangements and genomic rearrangements
2
2
How much good can be attributed to social science theories?
< 1
0
RNA-mediated genetic engineering (Part 3)
< 1
0
RNA-mediated genetic engineering (Part 2)
3
0
RNA-mediated genetic engineering
2
0
RNA-mediated events are not a matter of faith
2
0
Color vision refutes the evolutionary dogma of gene duplication
4
0
Unassailable evidence vs assumptions
4
0
Forces of "Nature" limit dissemination of information
4
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2
0
Systems biology and memory disorders
3
0
RNA-mediated cell type differentiation and behavior
3
0
Different physical locations and different molecular mechanisms of health and disease
2
0
Metabolism, fixation, health or neurodegerative disorder
2
0
Physics, Chemistry, and Molecular biology (PCMb)
2
0
Physics denied; pseudoscientific nonsense accepted
2
0
Ecological variation and niche construction: 1, 2, 3
6
0
Epigenetically-effected metabolic shifts and ecological adaptations
3
0
Evolving DNA before RNA
4
0
Stop evolutionary theorists. Kill cancers
3
0
Did our adapted mind evolve? (Revisited)
2
0
De novo gene Creation sans evolution of genes via mutations
4
0
Did our adapted mind evolve?
6
0
RNA-directed DNA methylation and RNA-mediated events
5
1
Miracles are not miracles to evolutionary theorists
2
0
Mathematical model: microRNA and epigenetic regulation
2
0
Seemingly futile cycles are not thermodynamically futile
3
0
Do bacterial proteins evolve?
3
0
“Kardashians” in science
< 1
0
Probable changes in connectivity
2
0
New technique used in report of atomic-level ecological adaptations
3
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3
0
Memory of repression and memory of behavior (2)
< 1
0
Memory of repression and memory of behavior
2
0
Quantum physics meets Evolutionary Psychology News
2
0
Nutrient-dependent pheromone-controlled exercise-induced physiques
< 1
0
Watching and waiting for more retractions
2
0
RNA-mediated ecological adaptations of teeth
4
0
A molecular visualizer of worthwhile molecular biology
2
0
RNA-mediated species diversification from microbes to primates
3
0
RNA-mediated events found everywhere
2
0
Reseachers think copy number variation is genetically determined
< 1
0
Some neuroscientists think a mutation led to human language development
< 1
0
Genotype, observed phenotype, and distinctly disordered behaviors
3
0
Is the problem an internet echo or Feierman's ethics?
2
0
Behavior (3): All responses are RNA-mediated in bees
3
0
RNA-mediated ecological adaptation is not evolution
2
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4
0
Behavior: The first response is RNA-mediated not genetically-determined
3
0
Mechanisms that are not understood increase clarity
4
2
Pattern recognition and conserved receptors (TAARs)
5
0
Nutrient-dependent erythropoiesis and anemia
6
0
Evolutionary heritage or ecological adaptation? Racism versus reality
4
0
A relatively young branch of science called epigenetics
4
0
Insect homology and diversity attributed to mutations
2
0
Biophysically constrained beginnings of RNA and DNA
4
0
Baby talk: More misrepresentations of ecological adaptations
2
0
Comparing divergent model organisms
2
1
A microRNA-mediated mechanism that is epigenetically inherited
2
0
Epimutations: Attacking pseudoscientific dogmas
4
0
Order and disorder: Ecological adaptations not mutations
6
0
microRNAs differentiate neuronal cell types
3
0
microRNAs and species relationships
3
0
Drunks and Monkeys: Pseudoscientific nonsense
2
0
The quantum biology of consciousness
3
0
Behavior is receptor-mediated
10
0
Genes and Race: Human History?
2
0
Soft atheism: a case for Creation
< 1
0
Nutrition, pheromones and cancer (2)
2
0
Ecologically linked adapted ants and brains
2
0
MiRNAs methylation and ecological adaptation sans mutations
2
0
Not focused and self-aggrandizing
2
0
Nutrient-dependent cooperation vs cannibalism (video)
2
0
Cell-type differentiation
2
0
Another powerful refutation of mutation-initiated natural selection
4
0
The new light of chromosomal rearrangements
3
0
Darwinian theories vs Darwin's facts
2
0
Chromosomal rearrangements and ecological adaptations
4
0
The wrong picture of our evolution
4
0
96 fixed amino acid substitutions, not 96 genes
6
0
Jay R. Feierman
3
0
Don't tell the Creationists
2
0
Targeting a cancer gene
2
0
Alternative splicings (very technical)
2
0
Pulses of olfactory/pheromonal input
2
0
Pheromone-controlled thermodynamics and cancer
2
0
Seeds of life: astrobiological theory and mutations theory
3
0
Your comment is awaiting moderation
2
0
Nutrient-dependent pheromone-controlled stickleback evolution
2
0
Functional coding variants are not mutations
2
0
Mirror neurons and microRNA: theory vs biological facts
4
0
Understanding the role of mutations and evolution
4
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2
0
Pheromones and cancer
4
0
Are pheromones responsible for human body odour assessment?
2
0
Comparative, developmental, neurobehavioral, sexual dimorphisms
< 1
0
Sex differences in Alzheimer's and everything else
2
0
Human Pheromones: theory vs models
3
0
CB Nemeroff: Off Restriction
< 1
0
Species specificity in gene expression in the brain
2
0
A thought experiment
3
0
More than speculation: adaptive evolution in species from microbes to man
2
0
Cookbook chemistry: food odors and hormones
< 1
0
Honeybees, food odors, and perfume
< 1
0
Pheromones and a realistic model of sexual differentiation
3
0
Results: increased flirtatious behavior and self-reported attraction
2
0
(click to enlarge)