Amino acid homeostasis for a Happy New Year!
(click to enlarge)
Works by Christ et al., continue to attest to the rejuvenating power of blood. For example, in the context of epigenetic pharmacology and regenerative medicine , one protein in the blood has been linked to health via nutrient-dependent amino acid substitutions that differentiate all cell types in all individuals of all species. Simply put, blood seems to reverse aging in another mammal, which suggests an across-species link to RNA-mediated amino acid substitutions. For contrast, nothing currently known about any species links beneficial mutations to health. That’s because mutations perturb protein. Mutations that perturb protein folding typically lead to pathology. Only evolutionary theorists continue to insist that beneficial mutations exist. Without them, their theories are based on nothing more than pseudoscientific nonsense. For comparison to Christ’s works, see:
Abstract excerpt: We found that autosomal recessive TPP2 mutations cause recurrent infections, autoimmunity, and neurodevelopmental delay in humans. We show that a major function of TPPII in mammalian cells is to maintain amino acid levels and that TPPII-deficient cells compensate by increasing lysosome number and proteolytic activity. However, the overabundant lysosomes derange cellular metabolism by consuming the key glycolytic enzyme hexokinase-2 through chaperone-mediated autophagy. This reduces glycolysis and impairs the production of effector cytokines, including IFN-γ and IL-1β. Thus, TPPII controls the balance between intracellular amino acid availability, lysosome number, and glycolysis, which is vital for adaptive and innate immunity and neurodevelopmental health.
See also the graphical abstract below, which is from this URL
Caption: “A new form of immunodeficiency in humans caused by mutations in the enzyme tripeptidyl peptidase II reveals a new connection between amino acid homeostasis and immunometabolism.”
My comment : I reiterate, mutations perturb protein folding. In the report linked above, “…mutations cause recurrent infections, autoimmunity, and neurodevelopmental delay in humans.” Amino acid substitutions stabilize protein folding. See above: “…TPPII controls the balance between intracellular amino acid availability, lysosome number, and glycolysis, which is vital for adaptive and innate immunity and neurodevelopmental health.”
Controlled nutrient-dependent amino acid homeostasis is required for cell type differentiation in the context of epigenetic links from metabolic networks linked to genetic networks. These networks include what is known about immunometabolism, which links thermodynamic cycles of nutrient-dependent protein biosynthesis and degradation to organism-level thermoregulation via the de novo creation of olfactory receptor genes. The creation of these olfactory receptor genes enables receptor-mediated self vs non-self recognition. The de novo creation of any receptor requires systems level complexity that typically is dismissed by theorists and attributed to mutations.
However, in the context of one of Science Magazine’s 2014 Breakthroughs of the year, there are two reports that link nutrient-dependent RNA-directed DNA methylation and RNA-mediated amino acid substitutions in the blood from olfaction to regeneration of cells in tissues of organs and organ systems of mammals.
Editor’s Summary excerpt : Two teams analyzed the effects of heterochronic parabiosis in mice. Sinha et al. (p. 649) found that when an aged mouse shares a circulatory system with a youthful mouse, the aged mouse sees improved muscle function, and Katsimpardi et al. (p. 630) observed increased generation of olfactory neurons. In both cases, Growth Differentiation Factor 11 appeared to be one of the key components of the young blood.
Taken together, the works clearly link the experience-dependent nutrient-dependent de novo creation of olfactory receptor genes to increased olfactory acuity via the circulatory system in the context of regenerative medicine.
See Christ et al (2013) . His group appears to have presaged the latest reporting on regenerating life by placing it into the context of nutrient-dependent RNA-mediated amino acid substitutions.
Excerpt: “Collagen (RGD), fibrin (RGD), laminin (YIGSR), and keratin (LDV) all contain three to five amino acid sequences that promote cell binding through integrin or other interactions (Fig. 7Aiii).”
My comment: The amino acid sequences link the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man via conserved molecular mechanisms. See for examples: Nutrient-dependent/pheromone-controlled adaptive evolution: a model .
Christ’s amino acid sequences appears to be linked via the circulatory system to the nutrient-dependent stability of organized genomes. For example, the circulatory system of vertebrates and invertebrates links epigenetic effects on the nutrient-dependent pheromone-controlled physiology of reproduction to the bio-physically constrained fixation of amino acid substitutions via the chemistry of protein folding in species from microbes to man.
The question arises: “Has anyone credited Christ et al., with his group’s scientific breakthrough? It appears to have presaged another report of a 2014 Breakthrough of the Year. That breakthrough suppposedlly somehow links dinosaurs to the evolution of birds. Christ’s breakthrough makes the link from dinosaurs to birds untenable unless it is placed into the context of pseudoscientific nonsense touted by evolutionary theorists, which is based on de Vries definition of ‘mutation’ and assumptions that mutations could somehow be linked to increasing organismal complexity.
[W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et al. did was invent…. Evolution was defined as “changes in gene frequencies in natural populations.” The accumulation of genetic mutations was touted to be enough to change one species to another…. Assumptions, made but not verified, were taught as fact. Mazur (2014)
Given what is already known about The Pharmacology of Regenerative Medicine in the context of nutrigenomics and pharmacogenomics, which link metabolic networks to genetic networks, theories about beneficial mutations seem more ridiculous than ever. Christ’s works clearly show why heterochronic parabiosis leads to regeneration of cells in tissues of organs and organ systems of mammals. Regeneration is the likely outcome associated with blood-borne epigenetic effects on receptor-mediated events in all tissue types.
Others claim “…there is a lack of studies that demonstrate causal links between epigenetic change and tissue function .” They have also invented the term “allosteric mutations” in an effort to link something besides experience-dependent receptor-mediated changes in cell types to increasing organismal complexity manifested in biodiversity. They claim that biodiversity somehow evolved, but no experimental evidence of biologically-based cause and effect supports their claims.
Instead, we continue to see experimental evidence of how the Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities . Experimental evidence shows that nutrient-dependent changes in the microRNA/messenger RNA balance link RNA-mediated amino acid substitutions to cell type differentiation, which is perturbed by mutations. Natural genetic variation enables ecological variation to lead to ecological adaptations via conserved molecular mechanisms. Everything currently known to intelligent serious scientists shows Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment and that epigenetic effects of food odors and pheromones shape the local microenvironment as exemplified in Feedback loops link odor and pheromone signaling with reproduction.
All biologically-based facts reported during the past year link feedback loops to A 3D Map of the Human Genome at Kilobase Resolution [that] Reveals [the] Principles of Chromatin Looping . Indeed, the reporting of the 2014 Breakthrough in regenerative medicine included a link to a video representation of the report on chromatin looping Reversing Aging Processes with One Protein: a 2014 Breakthrough
VIDEO
The likelihood that mutations, which perturb protein folding, contribute to anything but pathology appears to have been all but eliminated from the thoughts of intelligent serious scientists during the past year. For additional examples of what serious scientists now know about biologically-based cause and effect, see: A red meat-derived glycan promotes inflammation and cancer progression .
It may be important to remember that molecular mechanisms of nutrient-dependent pheromone-controlled cell type differentiation are conserved across all species. Human pheromone-deniers would rather you think that we have somehow escaped from bio-physical constraints on chemistry folding and cell type differentiation via amino acid substitutions. They will almost undoubtedly also continue to support the evolution industry’s claims that “…genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world.” (p. 199 ) But watch the video linked above at least once to see how ridiculous that claim has become in the context of what is known about nutrient-dependent protein folding and pheromone-controlled gene expression. See also:Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
I suspect that anyone who is not an evolutionary theorist will make even more scientific progress during 2015. Happy New Year! Indeed, forthcoming information about Epigenetic mechanisms underlying learning and the inheritance of learned behaviors also attests to the role of nutrient-dependent RNA-directed DNA methylation and RNA-mediated amino acid substitutions in cell type differentiation linked to learned behaviors in all species. This suggests that If you learnt evolutionary biology and genetics a decade or more ago you need to be aware that those debates have moved on very considerably, as has the experimental and field work on which they are based. (p 1014)
Simply put, if you don’t begin to quickly learn in the new year what has been known to serious scientists for more than a decade, you are less likely to have a Happy New Year than those who remain biologically uninformed.
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Teleophobes vs teleophiles: a recent history
2 MIN READ
0
Ecological genomics: teleophobes respond (too late)
10 MIN READ
0
Genes, orchid odors, and pheromones from blonds
5 MIN READ
0
RNA-mediated theory killers (11) (12) (13) (14) (15)
7 MIN READ
0
Finding peace and π in the light of H bond energy (2)
8 MIN READ
0
MicroRNA-mediated RNA epigenetics
2 MIN READ
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Epigenetic (re)programming of behavior (3)
5 MIN READ
0
Assumptions prove ignorance
5 MIN READ
0
Neo-Darwinian sink testing
2 MIN READ
0
Life history transitions and RNA-mediated survial
2 MIN READ
0
Did Brain Atrophy Evolve?
2 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
Researchers rename, reshuffle, and reveal their ignorance
3 MIN READ
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
0
Does metabolism link beneficial mutations to cancer?
10 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (3)
3 MIN READ
0
Manufacturing fossil “evidence”
4 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (3)
7 MIN READ
0
Essential pseudoscientific concepts of atheism
3 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
RNA-mediated theory killers
6 MIN READ
0
Natural cooperation and Evolution 2.0
6 MIN READ
0
A million dollar paradox?
2 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (5)
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
Teaching the biologically uninformed
3 MIN READ
0
Innovative Neurotechnologies Link Sunlight to Precision Medicine
4 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
0
Neo-Darwinism vs the neocortex
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Nutrient-dependent trophic analogs
3 MIN READ
0
Plasma created by sunlight and RNA–mediated epigenetic heredity
2 MIN READ
0
Positive feedback loops and epigenetic traps
2 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Stress-perturbed mitochondrial dysfunction
4 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
Let there be anti-entropic light (3)
6 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Sensationalizing no new mechanism
2 MIN READ
0
Cell type differentiation: atoms to ecosystems
2 MIN READ
0
Too complex for the Complex Biological Systems Alliance
4 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Rediscovering quantum behavior
2 MIN READ
0
From dust to genomic entropy?
3 MIN READ
0
Virus, transposon and plasmid evolution
< 1 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Models are not theories (1)
2 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Can veterans and other prisoners escape pseudoscience?
2 MIN READ
0
eQTLs and ecological adaptation
< 1 MIN READ
0
RNA central and RNA-mediated.com
6 MIN READ
0
Ecological speciation. Get it, theorists?
< 1 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
Controled Stem Cell Expansion
3 MIN READ
0
Neo-Darwinian logic is nonsense
3 MIN READ
0
Human pheromone deniers: What’s next?
5 MIN READ
0
FREE* SAMPLE: Histone modification
4 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Biophysically constrained or unconstrained?
2 MIN READ
0
Mutated mitochondrial genes vs Supercoiled DNA
2 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs model
2 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
The Current State of Neuroscience
3 MIN READ
0
Cancer: forward and reverse
2 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Keep the gay gene theory?
< 1 MIN READ
0
Bird watchers and RNAs in cancers
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Microbes to humans 2015 Nobel Prize
2 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Theorists have not seen the light (2)
3 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
A 5-10K comparison of design principles to evolution
3 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Nucleic acids: Stability of DNA/RNA
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (3)
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (2)
< 1 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Multi-omic analysis features (SNPs, miRNA)
3 MIN READ
0
Anti-entropic effects on the origin of life
< 1 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
From fertilization to RNA-mediated events and back
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
Metabolic competition and cancer
2 MIN READ
0
Natural selection: an anti-entropic force?
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Creating genes and species
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
A “new” code enables ecological adaptation
4 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
RNA-mediated X chromosome inactivation
3 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Atomic-resolution of cell type signaling
4 MIN READ
0
Information and communication (2)
6 MIN READ
0
Unraveling evolutionary pseudoscience
2 MIN READ
0
Eibi Nevo gets it wrong
3 MIN READ
0
Rs3827760 is Val370Ala and EDARV370A
3 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Protosuns, prebiotic molecules, proteins, and people
4 MIN READ
0
Mammalian-wide interspersed repeats (MIRs)
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
The stability of organized genomes (2)
5 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Light -induced nucleic acid-mediated gene duplication?
< 1 MIN READ
0
Is the best Chinese research from China?
3 MIN READ
0
The stability of organized genomes
5 MIN READ
0
Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Big Bang Cosmology vs Reality
< 1 MIN READ
0
RNA-mediated terms of virus-induced en-deer-ment
2 MIN READ
0
Domestication via a single amino acid substitution
2 MIN READ
0
Hematopoiesis and practopoiesis
4 MIN READ
0
RNA-mediated morphological AND behavioral phenotypes
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Riding the wrong direction
3 MIN READ
0
Decreased phenotypic variation: Faith in Facts
7 MIN READ
1
Faithfully repaired DNA
5 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
The RNA-mediated sum of our parts
2 MIN READ
0
Celebrating independence from ridiculous theories
3 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
Olfactory perception of genetic information
2 MIN READ
2
Nutrient stress-induced RNA-mediated pathology
< 1 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
RNA-mediated events from A to Z
2 MIN READ
0
What I cannot create I eliminate from discussion
3 MIN READ
0
RNA-mediated development (3)
5 MIN READ
0
RNA-mediated development (2)
< 1 MIN READ
0
RNA-mediated development
2 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
Healthy mutants
2 MIN READ
0
Uniquely epigenomic gene regulation
2 MIN READ
0
MicroRNAs and inappropriate functions
2 MIN READ
0
Rejecting pseudoscientific nonsense
6 MIN READ
1
Living the life that randomness created? (Sarcasm alert)
3 MIN READ
0
30 years of theoretical nonsense
3 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Physicians who practice evolutionary medicine?
3 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Tweaking the story to fit the theory
5 MIN READ
0
Appetite for ingesting theories (raw)
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
One amino acid substitution, genes, and brain activity
3 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Bee-birthed epigenetics and primate cell types
5 MIN READ
0
A lighting requirement for life
11 MIN READ
3
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Bees and primates automagically evolve
3 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Five years of Ferguson
2 MIN READ
0
Computing via phosphorylation and fixation
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
The microbiome, pharmacogenetics, and privacy
< 1 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
Viruses in gut microbes
4 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
Finding odor and taste receptors everywhere
6 MIN READ
0
Linking the origin of birds to dinosaurs
< 1 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
Tet3 regulation of nutrient-dependent cell type differentiation
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Viruses, proteins, and gut metagenomes do not evolve
< 1 MIN READ
0
Pathology constrains X-linked evolution
2 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Viruses and cell type differentiation
3 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes (2)
10 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
MicroRNAs and invasive phenotypes
< 1 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Deeply ingrained thoughts
< 1 MIN READ
0
Graphic misrepresentations of ecological adaptation
2 MIN READ
0
Too many targets for theories
3 MIN READ
0
Methylation maintains cell type differences (2)
2 MIN READ
0
Methylation maintains cell type differences
3 MIN READ
0
Creating nothing but a theory (3)
4 MIN READ
3
Creating nothing but a theory (2)
4 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic effects of soil bacteria on plants
< 1 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Correctly modeling life on this planet
3 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Behavior (4): All responses are RNA-mediated in birds
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Virus-driven origin of life
2 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
RNA-directed gene choice
5 MIN READ
0
Walk towards the light
< 1 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
Epigenetics Skeptism
5 MIN READ
0
Assembling yourself: Molecular self / other recognition
4 MIN READ
0
What about birds?
5 MIN READ
0
Virus-driven cell type differentiation
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3 MIN READ
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
Imagining that data historically supports evolutionary theory
7 MIN READ
0
Atheism: Arrogant, useless, and divisive ignorance
7 MIN READ
0
The anti-entropic force of "Nature"
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease (2)
3 MIN READ
0
Military combat training to fight disease
3 MIN READ
0
Theoretical physics and molecular biology
5 MIN READ
0
Atoms to ecosystems is not almost a molecular ecology
3 MIN READ
0
Epigenetic effects of viruses on cellular homeostasis (2)
2 MIN READ
0
RNA-mediated epigenetic modification via DNA-methylation
4 MIN READ
0
Quantum physics, quantum biology, and quantum consciousness
4 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Biological energy and a microbiome model of a light-driven time machine
3 MIN READ
0
The biologically-based origin of the mammalian placenta (2)
6 MIN READ
0
Quantum Superpositions: let there be light
4 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Sneaking up from behind (2)
3 MIN READ
0
Sneaking up from behind
4 MIN READ
0
Quantum entanglement, mass, and biomass
4 MIN READ
0
Physicists: Desperate Acts
16 MIN READ
0
An epigenetic trap (the sequel)
10 MIN READ
0
Mute points: most are afraid to mention them
6 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
All of "like kind" in the (bigger) family
6 MIN READ
1
Environment epigenetically shapes the immune system
3 MIN READ
0
Beneficial microbes kill beneficial mutations
4 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
0
Unconstrained evolutionary innovability
4 MIN READ
0
RNA-protein interactions reveal biophysical to ecological landscapes
2 MIN READ
0
Mutagenesis: Replacing facts with theories
5 MIN READ
0
ISHE's human ethology group
2 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Unified nutritional and molecular mechanisms
9 MIN READ
0
Removing natural selection; reshaping the horse; adjusting evolutionary theory
4 MIN READ
0
Communication, not mutations
2 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
The future of physics predicts no future for evolutionary theory
3 MIN READ
0
Model organisms: the birds and the bees
3 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Atoms to ecosystems: Evolutionary theory vs the coelacanth
6 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Jumping back: Science or Pseudoscience?
6 MIN READ
0
Single-cell level assay of protein biosynthesis and degradation
2 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
One test of bioenergetic health?
2 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Eliminating correlations from evolutionary ecology
6 MIN READ
0
RNA-mediated species specificity
2 MIN READ
0
Are mutations beneficial?
4 MIN READ
0
The key to science: experimental evidence
5 MIN READ
0
Ecological adaptations reported as evolution in insects and mammals
4 MIN READ
0
There’s a model for that!
5 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
SNPs and millions of small variations in the human genome
3 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Achiral GnRH: no prophesy, just prediction
9 MIN READ
0
Nothing new under the sun, except pseudoscientific nonsense
6 MIN READ
0
Making sense of quotes scattered across disciplines
2 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
De novo DNA methylation?
3 MIN READ
0
RNA eclipses the importance of DNA to cell type differentiation
4 MIN READ
0
We need pattern recognition, not proclamations
3 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
Pharmacogenomics
3 MIN READ
0
Sexual differentiation of cell types in plants
2 MIN READ
0
A model of MHC 'evolution'
2 MIN READ
0
From deep time into real time: What evolutionary processes?
10 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
It’s cell type differention, not cell fate determination (2)
3 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
ALPHA GENOMIX
7 MIN READ
2
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
Evolutionary theorists and evolutionary theists live under rocks
< 1 MIN READ
0
No understanding of biodiversity
2 MIN READ
0
Understanding physical forces of ecological variation and adaptation
< 1 MIN READ
0
Eliminating evolutionary theory
3 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
2014 and 2004 Nobel Prize in Medicine
3 MIN READ
0
RNA-mediated events: chromosomal rearrangements and genomic rearrangements
2 MIN READ
2
How much good can be attributed to social science theories?
< 1 MIN READ
0
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
RNA-mediated genetic engineering (Part 2)
3 MIN READ
0
RNA-mediated genetic engineering
2 MIN READ
0
RNA-mediated events are not a matter of faith
2 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Unassailable evidence vs assumptions
4 MIN READ
0
Forces of "Nature" limit dissemination of information
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Systems biology and memory disorders
3 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Epigenetically-effected metabolic shifts and ecological adaptations
3 MIN READ
0
Evolving DNA before RNA
4 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
Did our adapted mind evolve? (Revisited)
2 MIN READ
0
De novo gene Creation sans evolution of genes via mutations
4 MIN READ
0
Did our adapted mind evolve?
6 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Miracles are not miracles to evolutionary theorists
2 MIN READ
0
Mathematical model: microRNA and epigenetic regulation
2 MIN READ
0
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Do bacterial proteins evolve?
3 MIN READ
0
“Kardashians” in science
< 1 MIN READ
0
Probable changes in connectivity
2 MIN READ
0
New technique used in report of atomic-level ecological adaptations
3 MIN READ
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
Memory of repression and memory of behavior (2)
< 1 MIN READ
0
Memory of repression and memory of behavior
2 MIN READ
0
Quantum physics meets Evolutionary Psychology News
2 MIN READ
0
Nutrient-dependent pheromone-controlled exercise-induced physiques
< 1 MIN READ
0
Watching and waiting for more retractions
2 MIN READ
0
RNA-mediated ecological adaptations of teeth
4 MIN READ
0
A molecular visualizer of worthwhile molecular biology
2 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
RNA-mediated events found everywhere
2 MIN READ
0
Reseachers think copy number variation is genetically determined
< 1 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Genotype, observed phenotype, and distinctly disordered behaviors
3 MIN READ
0
Is the problem an internet echo or Feierman's ethics?
2 MIN READ
0
Behavior (3): All responses are RNA-mediated in bees
3 MIN READ
0
RNA-mediated ecological adaptation is not evolution
2 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4 MIN READ
0
Behavior: The first response is RNA-mediated not genetically-determined
3 MIN READ
0
Mechanisms that are not understood increase clarity
4 MIN READ
2
Pattern recognition and conserved receptors (TAARs)
5 MIN READ
0
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
Evolutionary heritage or ecological adaptation? Racism versus reality
4 MIN READ
0
A relatively young branch of science called epigenetics
4 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
Baby talk: More misrepresentations of ecological adaptations
2 MIN READ
0
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
microRNAs differentiate neuronal cell types
3 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Drunks and Monkeys: Pseudoscientific nonsense
2 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Behavior is receptor-mediated
10 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
Soft atheism: a case for Creation
< 1 MIN READ
0
Nutrition, pheromones and cancer (2)
2 MIN READ
0
Ecologically linked adapted ants and brains
2 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
Not focused and self-aggrandizing
2 MIN READ
0
Nutrient-dependent cooperation vs cannibalism (video)
2 MIN READ
0
Another powerful refutation of mutation-initiated natural selection
4 MIN READ
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The new light of chromosomal rearrangements
3 MIN READ
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Darwinian theories vs Darwin's facts
2 MIN READ
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Chromosomal rearrangements and ecological adaptations
4 MIN READ
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The wrong picture of our evolution
4 MIN READ
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96 fixed amino acid substitutions, not 96 genes
6 MIN READ
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Jay R. Feierman
3 MIN READ
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Don't tell the Creationists
2 MIN READ
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Targeting a cancer gene
2 MIN READ
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Alternative splicings (very technical)
2 MIN READ
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Pulses of olfactory/pheromonal input
2 MIN READ
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Social experiences epigenetically effect gene networks
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
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Seeds of life: astrobiological theory and mutations theory
3 MIN READ
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2 MIN READ
0
Nutrient-dependent pheromone-controlled stickleback evolution
2 MIN READ
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Functional coding variants are not mutations
2 MIN READ
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Mirror neurons and microRNA: theory vs biological facts
4 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
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Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
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Are pheromones responsible for human body odour assessment?
2 MIN READ
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Hormones effect sensitivity to androsterone
2 MIN READ
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A flawed model: no tripartate synapse in the adult brain
3 MIN READ
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Music to our ears and song in birds: a common sense approach
2 MIN READ
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The challenges of a Darwinian approach to anything
3 MIN READ
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Sex differences in Alzheimer's and everything else
2 MIN READ
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How Species Diversify
2 MIN READ
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The same neural mechanisms are at work in worms and humans
2 MIN READ
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Epigenetic effects on the evolution of behavior
2 MIN READ
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CB Nemeroff: Off Restriction
< 1 MIN READ
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Human pheromones and inner conflict about evolution (1102 words)
4 MIN READ
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A thought experiment
3 MIN READ
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Human pheromones and the visual appeal of other people (Part Three)
2 MIN READ
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Human pheromones and the visual appeal of other people (Part Two)
2 MIN READ
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Human pheromones and your immune system
< 1 MIN READ
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A fallacious leap? Ancestral and derived traits
3 MIN READ
0
Modeling odor processing in microbes, mice, and mankind
2 MIN READ
0
Human Pheromones in Socioaffective Neuroscience & Psychology
2 MIN READ
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The biology of behavior: Seeing more clearly
< 1 MIN READ
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Do Pheromones Play a Role in Our Sex Lives: Scientific American
< 1 MIN READ
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Docosahexaenoic acid and autism: praying for hope, or preying on hope
< 1 MIN READ
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Timing is key in the proper wiring of the brain: study
2 MIN READ
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Progress in brain research (e.g., starting over)
< 1 MIN READ
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Honeybees, food odors, and perfume
< 1 MIN READ
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Avian recognition of human faces
< 1 MIN READ
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A lesser role for olfaction and pheromones in humans?
1 MIN READ
0
Pheromones and sexual behavior in birds
< 1 MIN READ
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