Two types of microRNA are not double agents

By: James V. Kohl | Published on: March 16, 2015

Study details microRNA’s role as a double agent during Hep C infection

By coopting miRNA-122, the virus appears to alter gene expression in the liver

Excerpt: “What if chronic low levels of miRNA-122 prompt changes that, over years, contribute to liver damage and cancer? This could be a molecular link between the viral infection and the pathologies associated with hepatitis C,” Luna says. “More work on miRNA-122 targets in hepatitis C-infected patients may clarify why some go on to develop liver cancer and others don’t.”

My comment: The viral microRNA / nutrient-dependent microRNA balance is the determinant of how nutrient-dependent RNA-directed DNA methylation and RNA-mediated amino acid substitutions differentiate health from physiopathology. Nutrient-dependent microRNAs prevent the entropic elasticity that leads to viral microRNA-linked physiopathology. For example, during thermodynamic cycles of protein biosynthesis and degradation, nutrient-dependent microRNAs are linked from RNA-mediated amino acid substitutions to the stability of protein folding in organized genomes.

The nutrient-dependent microRNAs also link RNA-mediated cell type differentiation from the metabolism of nutrients by the liver to the control of reproduction in mammals. For example, the metabolism of nutrients to species-specific pheromones controls the physiology of reproduction that enables fixation of the amino acid substitutions in the organized genomes that the fixations stabilize.

This misrepresentation of the two different types of microRNAs as one type that acts as a double agent can be placed into the context of pseudoscientific nonsense about beneficial mutations and evolution. Attempts to portray how low levels of microRNAs contribute to disease without mention of how nutrient-dependent microRNAs control the viral microRNAs that cause disease is a one-sided view that appears to be based in evolutionary theory, not what is known about cell type differentiation.

See also: 

Organisms can keep gene expression in check, biologist says

Nutrients keep gene expression in check by preventing viral microRNAs from causing the entropy associated with entropic elasticity.  Nutrients provide the the anti-entropic energy that controls cell type proliferation.


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