MicroRNAs and the exposome (2)
(click to enlarge)
Excerpt 1)
Chemical modifications to these histones can change the expression of genes, making them more available for expression or silencing them by compacting the DNA-protein complex. Oddball H3.3 varies from its regular counterpart H3 by only few amino acids.
Excerpt 2)
The research has implications beyond epigenetics. “This study also hints at a fascinating question in biology: How do cells balance the potential evolutionary benefit of mobile elements, such as retrotransposons, with the competing need to silence them so as to maintain the genome?” she says.
My comment: Cells do not balance the ‘potential evolutionary benefit’ of viral microRNAs. The entropic elasticity that links viral microRNAs to pathology is balanced by the anti-entropic epigenetic effect of nutrient-dependent microRNAs. Nutrient-dependent microRNAs link beneficial changes in the microRNA/messenger RNA balance to RNA-mediated amino acid substitutions that differentiate all cell types of all individuals of all genera. The need to control the entropy caused by viruses arises in the context of fixation of the amino acid substitutions via the physiology of reproduction. Fixation is nutrient-dependent and pheromone-controlled in species from microbes to man. Researchers who wonder “How do cells balance the potential evolutionary benefit of mobile elements…” have framed the question in the context of ridiculous theories, and they may need to begin learning about the biologically-based cause and effect manifested in cell type differentiation.
See also: MicroRNAs and the exposome
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< 1 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Life: conserved ion and amino acid transporters
3 MIN READ
0
Graphic misrepresentations of ecological adaptation
2 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
Epigenetic effects of soil bacteria on plants
< 1 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Correctly modeling biological energy
2 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Behavior (4): All responses are RNA-mediated in birds
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Virus-driven origin of life
2 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
Walk towards the light
< 1 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
Epigenetics Skeptism
5 MIN READ
0
Is DNA-directed transcription RNA-mediated?
2 MIN READ
0
Assembling yourself: Molecular self / other recognition
4 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
Imagining that data historically supports evolutionary theory
7 MIN READ
0
Atheism: Arrogant, useless, and divisive ignorance
7 MIN READ
0
The anti-entropic force of "Nature"
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
Communication, not mutations
2 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Jumping back: Science or Pseudoscience?
6 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Epigenetically-effected metabolic shifts and ecological adaptations
3 MIN READ
0
Memory of repression and memory of behavior
2 MIN READ
0
RNA-mediated events found everywhere
2 MIN READ
0
Pattern recognition and conserved receptors (TAARs)
5 MIN READ
0
Ecologically linked adapted ants and brains
2 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
Cell-type differentiation
2 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Seeds of life: astrobiological theory and mutations theory
3 MIN READ
0
Epigenetic effects underlie sexual preferences III
3 MIN READ
0
Epigentics and the baby connectome
2 MIN READ
0
Epigenetics and the connectome
2 MIN READ
0
Behavioral epigenetics
2 MIN READ
0
Genes, Hormones, and Behavior (for other scientists)
4 MIN READ
0
Epigenetics, science fiction, and scientific fact
2 MIN READ
0
