Nutrient stress-induced RNA-mediated pathology

By: James V. Kohl | Published on: June 20, 2015

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease

Reported as:

Fructose powers a vicious circle

Excerpt:
The central fructose-metabolising enzyme is ketohexokinase (KHK), which exists in two isoforms: KHK-A and KHK-C, generated through mutually exclusive alternative splicing of KHK pre-mRNAs.
My comment: The role of nutrient-dependent RNA-mediated alternative splicings of pre-mRNAs in cell type differentiation was linked from yeasts to mammals in 1996. Nothing known about biolgically-based cause and effect has changed since then.
See our section on molecular epigenetics in the Hormones and Behavior review article:

From Fertilization to Adult Sexual Behavior

Excerpt:
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

My comment: Cell type differentiation in all cell types of all individuals of all genera is RNA-mediated. Fixation of RNA-mediated amino acid substitutions occurs via the physiology of reproduction. See my invited review of nutritional epigenetics for examples.

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems


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