Is the best Chinese research from China?

By: James V. Kohl | Published on: August 4, 2015

8 and great: the best Chinese research of 2015 in Genome Biology

Excerpt 1)

They found that the relationship between mRNA and protein levels is increasingly unlinked during aging. This occurrence is likely caused by modifications to the mRNA that alter stability, or prevent translation into proteins. Many of the genes that were predicted to be targeted for these modifications are known to be involved in lifespan extension, mitochondrial function, and Alzheimer’s disease.

My comment: The modifications to the mRNA that alter stability are caused by the accumulation of viral microRNAs. The viral microRNAs perturb the nutrient-dependent microRNA/messenger RNA balance that is linked to healthy longevity.

Excerpt 2)
They found that highly expressed behavior-associated genes in worker (female) brains have unusually high crossover rates, but that immune-related genes do not. This is the first evidence linking cross over events with social behavior in honeybees.

My comment: The honeybee model organism exemplifies how nutrient-dependent microRNAs are linked to pheromone-controlled morphological and behavioral phenotypes during the life history transitions of all invertebrates and vertebrates via RNA-mediated fixation of amino acid substitutions.

Excerpt 3)

Assembling a genome from scratch, or de novo assembly, occurs in a series of steps: the assembly of overlapping reads into contigs, building contigs into scaffolds, and accurately ordering and orienting scaffolds into chromosomes.

My comment:  The de novo assembly of genomes does not arise from scratch. The de novo creation of amino acids must be linked to RNA-mediated events and nutrient-dependent amino acid substitutions. The RNA-mediated events lead creation of organized genomes in all living genera via the controlled physiology of nutrient-dependent reproduction. If the physiology of reproduction is not biophysically constrained, the accumulation of viral microRNAs will eventually cause the failure of the organism and/or species to ecological adapt to ecological variation.
Excerpt 4)

Geese are also a good model for studying liver metabolism in humans.

My comment: Liver metabolism is the link between nutritional epigenetics and pharmacogenomics that has led to more significant advances in personalized medicine than anyone could have expected as few as 10 years ago, which was the time when everything currently known about the microRNA/messenger RNA balance began to be linked to downstream effects on morphological and behavioral phenotypes in all living genera.
Excerpt 5)

Mutations can include anything from single nucleotide polymorphisms (SNPs), to sequence insertions and/or deletions (INDELs), while epigenetic changes include non-genetic aberrations. Each of these types of change has the potential to perturb a gene’s expression.

My comment:  RNA-mediated gene duplication and RNA-mediated nutrient-dependent fixation of amino acid substitutions link all aspects of what is required to link the physiology of reproduction to biodiversity in species from microbes to man via the nutrient-dependent pheromone-controlled organization of their genomes.

Nutrient-dependent epigenetic changes link RNA-mediated DNA repair to everything known about cell type differentiation, which is biophysically constrained by the chemistry of protein folding and perturbed by virus-driven mutations.

 

Slide speaks for itself.
Posted by James C. Coyne on Sunday, August 2, 2015

Riding the Evolution Paradigm Shift With Eugene Koonin

Excerpt:
…the new understanding of evolution needs to integrate what we now know about viruses and virus-host interactions which, from my own perspective, has been absolutely one of the key factors of all evolution since the emergence of cells — well, actually even before the emergence of cells.”

My comment: The new understanding of ecological variation links viruses to entropic elasticity and genomic entropy in the absence of nutrient-dependent RNA-mediated DNA repair that is required for ecological adaptation. If the understanding of how ecological variation leads to ecological adaptations comes from China, it will be because Chinese researchers, like researchers in Israel, have learned the difference between a mutation and an amino acid substitution.
Researchers who have been taught to believe in neo-Darwinian theories, do not seem to know anything about that difference. For example, Andrew Jones clearly does not: See: Criticisms of the nutrient-dependent pheromone-controlled evolutionary model
Excerpt:

Despite his valid publications involving endocrinology, sexuality, and epigenetically induced intraspecies differentiation in model organisms, James V. Kohl overextends his expertise in trying to overthrow established evolutionary theory.

My comment: Neo-Darwinian theory was never established in the context of facts about virus-driven changes in what must become nutrient-dependent organized genomes in the context of the physiology of reproduction.
Evolutionary theorists in the western world will be left with only their ridiculous theories if the Chinese start reporting their experimental evidence in the context of ecological speciation, which is clearly driven by viruses and controlled by the physiology of nutrient-dependent RNA-mediated amino acid substitutions in the context of reproduction in all genera.
If you do not yet believe in Chinese medicine, now would be a good time to reevaluate what you believe in — before your ridiculous beliefs are subjected to ridicule.


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