Metabolic competition and cancer

By: James V. Kohl | Published on: August 31, 2015

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Excerpt:

“…glucose consumption by tumors metabolically restricts T cells, leading to their dampened mTOR activity, glycolytic capacity, and IFN-ฮณ production, thereby allowing tumor progression.”

My comment: Does anyone know the difference between 1) a tumor that eats glucose and 2) viruses that steal nutrient-dependent energy from the cell types of all cells in all individuals of all living genera, which links viruses to perturbed RNA-mediated protein folding and pathology?
Hint: One of two thought processes above is a logical extension of everything known about biophysically constrained RNA-mediated cell type differentiation in all genera, the other is theoretical.
Reported as (see the diagram): Metabolic competition in the tumor microenvironment Is a driver of cancer progression
Excerpt:

DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action.

My comment: Nutrient-dependent microRNAs and RNA-directed DNA methylation are linked from the physiology of reproduction to fixation of amino acid substitutions and cell type differentiation, which is perturbed by viral microRNAs. The known mechanisms include links from microRNAs to adhesion proteins and from viruses to perturbed protein folding and all pathology.
The claim about “…anti-tumor efficacy via an unknown mechanism of action…” ignores what is known to serious scientists about the difference between mutations and amino acid substitutions in the context of RNA-mediated biodiversity in all genera. It is controlled by nutrient uptake and the physiology of reproduction. Controlled cell type differentiation of cell types is perturbed by viruses. Viral microRNAs link entropic elasticity to genomic entropy without the anti-entropic epigenetic effects of nutrients on DNA repair.
For contrast, evolutionary theorists have claimed that natural selection is the anti-entropic source of something linked to all biodiversity, which many of them think arises in the context of constraint-breaking mutations.
See: Mutation-Driven Evolution

…genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world. In this view of evolution there is no need of considering teleological elements” (p. 199).

 
 


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