Supercoiled DNA constrains virus-driven genomic entropy

By: James V. Kohl | Published on: October 13, 2015

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1) Genes linked with malaria’s virulence shared by apes, humans and
2) Supercoiled DNA is far more dynamic than the ‘Watson-Crick’ double helix were reported today.
One report (1) links viruses to the evolution of biodiversity in chimpanzees and humans compared to gorillas.
The other report (2) links nutrient energy-dependent base pair changes to RNA-mediated amino acid substitutions and DNA repair.

Both reports are linked to open access publications:

See 1) Ape parasite origins of human malaria virulence genes
Excerpt:

This Laverania species diversity provides an unprecedented opportunity to study the origins of genomic features that previously seemed unique to P. falciparum, such as the var gene family encoding erythrocyte membrane proteins. Here we show that various aspects of the multi-scale modularity of these loci can be recognized in diverse Laverania species, with the implication that a var or var-like gene family already existed in their last common ancestor.

My comment: The implication that gene families already existed in a last common ancestor are linked to the theoretical ghosts of the evolution industry. Despite a century of scientific progress, the ghosts are still linked to the gene-centric views of population geneticists. They used de Vries (1904) definition of “mutation” as the basis for assumptions about how long it would take for all extant or extinct biomass to automagically arise from a primodial soup. Sometime during that time apes evolved from microbes and became modern humans.
See also 2): Structural diversity of supercoiled DNA
Conclusion:

Our data provide relative comparisons of supercoiling-dependent twisted, writhed, curved, and kinked conformations and associated base exposure. Each of these structural features may be differentially recognized by the proteins, nucleic acids, and small molecules that modulate DNA metabolic processes.

My comment: The data that links small molecules, such as microRNAs, from metabolic networks to genetic networks, makes the claims of neo-Darwinian theorists the theme of this parody. It is an accurate representation of how nutrient-dependent base pair changes link ecological variation to ecological adaptation and all biomass on earth via what is currently known to serious scientists about base pair changes and RNA-mediated DNA repair.

Last week, I recorded a less technical representation of biologically-based cause and effect that placed squirrel-centric evolution into the context of current philosophy (we don’t know how species evolved) and claims of evolutionary theorists (random mutations and natural selection led to the theoretical basis of the “walnut crush” phenomenon). Sarcasm alert: Creationist claims are vaguely presented with no experimental evidence to support the idea that the walnuts grew on and fell from trees.

Obviously, no one can be perfectly sure that what is known about RNA-mediated epigenetic regulation of gene expression and RNA-mediated gene silencing link base pair changes to all extant biodiversity, or if de Vries definition of “mutation” and theories are the best approach to understanding the pathology of malaria. However, the 2015 Nobel Prize winners in Physics, Chemistry, and Physiology and/or Medicine have linked neutrinos to mass and the speed of light on contact with water from the light’s virucidal properties to the effective treatment of malaria via a water-based chemical extraction procedure described 1600 years ago.