Stress-perturbed mitochondrial dysfunction (2)

By: James V. Kohl | Published on: November 22, 2015

Biologically uniformed science idiots either refuse to discuss facts or try to bury them beneath the pseudoscientific nonsense of their ridiculous claims.

Study connects mitochondria to psychological stress response and species resilience

See the discussion of this news report on the Neuroscience FB group. With one exception, I’ve included only my own comments because my comments are tractable across what is currently known to serious scientists at a time when anonymous fools hope to disrupt the message from my serious of posts.

My comments:

Bruce McEwen coauthored this article about how ecological variation is linked to ecological adaptation via amino acid substitutions. In the early 90’s, he taught me to start my model with gene activation in GnRH neurosecretory neurons. Epigenetically-effected changes in the vertebrate hypothalamic GnRH pulse link food odors and pheromones to RNA-mediated cell type differentiation in species from microbes to man via what is known about nutrient-dependent RNA-mediated amino acid substitutions and biophysically constrained protein folding chemistry in all living genera.
See also:

The thermodynamic cycles of protein biosynthesis and degradation link nutrient stress and social stress to adaptations that must occur at the level of the mitochondria to prevent stress-perturbed protein folding that links viruses to mutations and genomic entropy.Mitochondrial dysfunction has since been attributed to the theft of nutrient-dependent energy by viruses, which is linked via mutation-perturbed protein folding to all pathology. Neo-Darwinian theorists seem to hate that fact, but the facts about biologically-based cause and effect have never changed. The facts continue to force neo-Darwinists to revise their theories with hopes that they can regain some credibility without admitting that they have been touting pseudoscientific nonsense since the time the “Modern Synthesis” was invented.
See for comparison: Epigenetics and animal virus infections

A new mechanism of nervous system plasticity: activity-dependent myelination

It has taken more than 8 years for neo-Darwinists to link this research from the nutrient-dependent pheromone-controlled physiology of reproduction in microbes to human behavior via the conserved molecular mechanisms that link RNA-mediated events to cell type differentiation in all living genera.

There is still no sign that theorists will ever learn anything about nutrient-dependent cell type differentiation.

See also: Little-known nerve may be secret to lust

Excerpt: “Fields has supporters, among them James Kohl, co-author of “The Scent of Eros,” a book on pheromones.“He’s right on,” Kohl said. “We have known there is some physical link, but [nerve zero] really helps to define it.

Maybe a lot of neuroscientists don’t know about it, but people who study the olfactory system and pheromones see that and say that’s really important.”

Please see: Human Life History Dimensions in Reproductive Strategies are Intuitive Across Cultures.  If you would like to discuss pseudoscientific nonsense somewhere else. I encourage you to go there.

The interpretation of their claim is ridiculous. “This mutation may compensate for the muscle regeneration problems caused by a lack of dystrophin, the authors suggest.” Suggesting that one mutation may compensate for another can be placed into the context of what is known to serious scientists about virus-perturbed protein folding, which cannot be linked to compensatory mutations via any known pathway of biophysically constrained protein folding, which is nutrient-dependent and RNA-mediated in the context of the physiology of reproduction and fixation of amino acid substitutions in species from microbes to humans.

See for comparison:  A small, microRNA-size, ribonucleic acid regulating gene expression and development of Shiga toxin-converting bacteriophage Φ24Β


“…we have demonstrated the existence of a microRNA-size molecule derived from phage Φ24B in E. coli cells. This small RNA, named 24B_1, has a physiological role, as the mutant phage lacking the region encoding its precursor revealed dramatic changes in expression of all tested phage genes, and significant differences in various developmental processes. To our knowledge, this is the first demonstration of physiological significance of a microRNA-sized molecule in bacterial cells.”

How many more people must die due to Weeny’s touting of pseudoscientific nonsense before someone complains to the moderator? Phage treatment of human infections

Let’s turn this into a FB group for discussion of facts, before it’s too late to help your loved ones who will probably suffer and die from stress-related disorders unless other serious scientists begin to focus on facts instead of ridiculous theories about cell type differentiation.

Crustaceans and insects were linked via the conserved molecular mechanisms I have detailed in a series of published works since book publication in 1995.

See: All in the (bigger) family

The links are from nutrient-dependent microRNAs and cell adhesion proteins to supercoiled DNA that protects organized genome from virus-driven entropy, you FOOL!

Success of new-generation metabolo-therapies in personalized medicine depends on measuring bioenergetic health

The environmental factors that enable links from ecological variation to ecological adaptation, which all serious scientists have linked to supercoiled DNA in organized genomes, are nutrient-dependent and controlled by the fixation of RNA-mediated amino acid substitutions in the context of the physiology of reproduction. No experimental evidence of biologically-based cause and effect suggests that use of the term “evolution” in the context of an atoms to ecosystems model of cell type differentiation is anything more than a throw-back to the time after de Vries defined the term “mutation” as a sudden energy jump. The pseudoscientific nonsense of population geneticists who invented neo-Dawinism was based on their assumptions about how long it might take for accumulated mutations (i.e., energy jumps) to lead to the evolution of a new species. As everyone here has repeatedly seen, WEENY is one of the few biologically uninformed science idiots who still thinks that is possible. Thus, he claims that use of the term “evolution” is an example of support for the most ridiculous theory that could ever have been imagined by Darwin, or anyone else who realized that ecological speciation is nutrient-dependent and controlled by the physiology of reproduction in all living genera.

RNA-mediated gene duplications are called mutations by biologically uninformed science idiots who do not know that gene duplication is nutrient energy-dependent. That means it doesn’t matter what YOU or anyone else calls gene duplications since serious scientists know how RNA-mediated cell type differentiation occurs.

Pat Sweeney  [aka Pat’s Weeney or WEENY): All gene duplications are called mutations Kohl, get over it your not entitled to claim otherwise. I agree that a mutation produced by gene duplication is different from a mution produced by gene insertion or deletion.

Re: “…a cascade of impacts.” The cascade links the effects of stress via the immune system to perturbed protein folding and to pathology via mutations, which exemplify how the accumulation of viruses alters morphological phenotypes and behavioral phenotypes. That is not an opinion, and there is no reason to be humble when expressing facts that have been established during the past two or three decades, just because theorists and other types of WEENY’s want to continue ignoring the facts!

They are supporting this claim:  Feedback loops link odor and pheromone signaling with reproduction

That claim was based on our claims in From Fertilization to Adult Sexual Behavior

All published works by all serious scientists have continued to support the claims we made in our section on molecular epigenetics. Only biologically uninformed science idiots have continued to try to support their ridiculous claims about mutations and evolution with even more ridiculous claims.

See for comparison:

1) Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity

2) The octopus genome and the evolution of cephalopod neural and morphological novelties

3) Structural diversity of supercoiled DNA


4) this video representation of facts about nutrient energy-dependent base pair changes linked from RNA-mediated gene duplication and RNA-mediated amino acid substitutions and all cell type differentiation in all living genera via their nutrient-dependent physiology of reproduction.


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