MicroRNAs vs Red Queen hypothesis

By: James V. Kohl | Published on: December 7, 2015

All About Molecular Biology

How MicroRNAs regulate gene expression in different cell types…
MicroRNAs constitute a recently discovered class of non-coding RNAs that play key roles in the regulation of gene expression…
Posted by All About Molecular Biology on Saturday, December 5, 2015
My comment: This is the best representation I have seen, and its less than 5 mintutes long. For comparison, my invited review of nutritional epigenetics for the journal “Nutrients” is available here:

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man.

See for comparison: This is the worst representation of biologically-based cause and effect that I have ever seen.

Fruit flies diversify their offspring in response to parasite infection


… active parasite signals or host immune signaling pathways that specifically respond to live parasites appear to be required for the full-blown recombination response.”


Overall, our work identifies a strong link between infection and recombination in animals and further extends the Red Queen hypothesis to include plastic changes in recombination in response to environmental stimuli


This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements.”

There is a problem caused by extending the pseudoscientific nonsense about the Red Queen hypothesis in attempts to explain what is known about biologically-based cause and effect to serious scientists. If serious scientists accept a hypothesis that is not supported by experimental evidence of biologically-based cause and effect that links atoms to ecosystems, they become pseudoscientists. Pseudoscientists teach others to become pseudoscientists, which is why the majority of students who are taught biology in the Western World have become pseudoscientists who tout pseudoscience as if it was mainstream science.
Mainstream science is represented in this parody.

Mainstream science also is represented here.

MicroRNAs, adhesion proteins, and reproduction

In my opinion, this represents how supercoiled DNA links atoms to ecosystems in the context of ever-changing DNA structure and function. If the organisms portrayed did not produce offspring, there would be no biodiversity.

The story about the re-evolved flagellum appears to exemplify the fact that mainstream science largely consists of pseudoscientific representations of biologically-based cause and effect.

My comment: The idea that a complex functional structure could evolve over a weekend would probably not be considered by any serious scientist. Similarly, the idea that god effects behavior would probably not be considered by anyone who is not a pseudoscientist.
For example, see: The god effect

To intensify the ‘god effect’ in people already attracted to religious ideas, my studies revealed, all we had to do was boost the activity of the neurotransmitter, dopamine, crucial for balanced emotion and thought, on the right side of the brain. But should dopamine spike too high, murderous impulses like terrorism and jihad could rear up instead.

My comment: Evolutionary theorists seem to frequently confuse the epigenetic effects of sensory input on hormones with the affect of hormones on behavior. Creationists link the love of God to effects on hormones that affect behavior in all invertebrates and vertebrates.
Evolutionary theorists seem to link their love of pseudoscientific nonsense from mutations to the evolution of different morphological and behavioral phenotypes. They cannot seem to grasp the fact that the behavior of all invertebrates and vertebrates is nutrient-dependent and pheromone-controlled — just as it is in all bacteria.
For example, Todd Ian Stark wrote:Most of the work relating dopamine to stable traits has been regarding extraversion
I replied:  Most of the work that links it to life history transitions in the honeybee model organism and humans has been placed into an atoms to ecosystems model of biologically-based cause and effect.
See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
The link from a single base pair change and single nutrient-dependent RNA-mediated substitution to differences in behavior during life history transistion includes Dobzhansky’s claim about cell type differentiation in three different primate species with different morphologies and behaviors linked to their life history transitions.

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla (p. 127).”

My comment: This tells us that terrorists are not created by their god. It also explains why terrorists can train adolescents to become terrorists by the early indoctrination into sects that take the love of god and use it to teach others to hate those who do not believe in the same god. Finally, neo-Darwinian theorists blame the love of a creator God for the hatred of others and the terrorist acts committed by others who hate.

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