Coulombic interactions facilitate polycombic adaptation

By: James V. Kohl | Published on: November 4, 2016

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RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly
Summary: Everything known to serious scientists about energy-dependent biophysically constrained RNA-mediated protein folding chemistry is attributed to “Nature” and evolution with no consideration for where the energy came from or where it goes when viruses use it for their replication.

I baited Sean Ovis, and caused him to join a discussion on “The Battlefield.“Sean Ovis regurgitated parts of my model when he wrote:
Excerpts:

This scenario is explored fully within my model which links virus-driven energy theft and genomic entropy in all ecosystems on Earth to energy-dependent RNA-mediated amino acid substitutions via olfaction and the innate immune system in the context of the physiology of reproduction, and is fully known to all serious scientists.

In this model all organized genomes in all tissues of all living genera are linked to nutrient-dependent RNA-mediated amino acid substitutions via symbiosis and the pheromone-controlled physiology of nutrient-dependent reproduction in biochemically-based ecosystems which protects energy-dependent ecological adaptations from virus-driven energy theft and genomic entropy. The model was about to be published when due to an unfortunate accident, I tripped and the only copy of the manuscript fell out of my pocket and was eaten by a small dog.

My reply: Please note: After my last encounter with Sean Ovis, he wrote:

“If you are a creation scientist, you can take comfort in the fact that as you get older, the control of these viral fragments is considerably weakened, and eventually one or more of these jumping genes will be let loose in your body to wreak havoc on your DNA. When that happens, you can thank God, because they will have brought you closer to him.”

Addendum: That will remain as one of the most vicious of all atheistic attacks on my model.

I’ve since added information on coulombic interactions to help others link angstroms to ecosystems in all living genera via the physiology of reproduction and fixation of RNA-mediated amino acid substitutions in supercoiled DNA, which protects all organized genomes from virus-driven entropy.

Sean Ovis bastardized the discussion of Quantum Consciousness, so I ended comments on the threat after attempting to get him and others to start their own OP.

See: James Kohl

Was Hitchens a self- described marxist-trotskyist who regarded the materialist conception of history as legitimate for explaining the human condition?

Sean Ovis “Language is elitist,” says Marx; however, according to la Tournier , it is not so much language that is elitist, but rather
the rubicon, and some would say the defining characteristic, of language. Bataille’s analysis of neocultural textual theory states that consciousness may be used to marginalize minorities. Thus, Lacan suggests the use of postsemantic feminism to challenge hierarchy.If one examines dialectic nationalism, one is faced with a choice: either accept postsemantic feminism or conclude that the task of the poet is social comment, given that culture is interchangeable with sexuality. The within/without distinction which is a central theme of Tarantino’s Pulp Fiction emerges again in Reservoir Dogs, although in a more mythopoetical sense. Therefore, if Lacanist obscurity holds, we have to choose between subpatriarchialist narrative and the capitalist paradigm of discourse.

In an attempt to move forward, I started a new OP based on the claims in: Peptides design based on transmembrane Escherichia coli’s OmpA protein through molecular dynamics simulations in water-dodecane interfaces

It seems futile to continue to address questions about the transfer of energy as information, when people cannot seem to grasp the fact that transfer must be biophysically constrained in the context of RNA-mediated protein folding chemistry that links coulombic interactions to polycombic adaptation, which prevents the hecatombic evolution of all virus-driven pathology.

Matthew Hunt, who is the co-author of “Electrostatic effects on linear and nonlinear waves in hanging film flows” (link opens pdf paper) continued to ask questions like this: You talk about the transfer of energy, but what is physically being transferred?

One of the administrators, Larry Kinser Jr., began to provide vague answers. His vague answers and proselytizing are all that I’ve seen come from the administrators of the group.

James Kohl Thanks for asking. Energy as information is being physically transferred as in the context of the Laws of Physics, which must be linked from the fundamentals of what is known about organic chemistry to Kohl’s Laws of Biology or Darwin’s ‘conditions of life,” which God established in the context of His Creation. Chemists know that — see for example:

See also: Gianmarc Grazioli YouTube Channel for Chemistry AND Guitar Tutorials!
See also: m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs
Excerpt:

These observations provide a mechanism for disrupting RNA structure through post-transcriptional modifications. The different propensities to form Hoogsteen base pairs in B-DNA and A-RNA may help cells meet the opposing requirements of maintaining genome stability, on the one hand, and of dynamically modulating the structure of the epitranscriptome, on the other.

My comment: For several years, others have also attempted to portray what they think are novel mechanisms of RNA-mediated cell type differentiation in the context of the epitranscriptome and epitranscriptomics. Their attempts seem to be nothing more than attempts to obfuscate the facts that have been known about the molecular epigenetics of RNA-mediated cell type differentiation for at least two decades.
See for example: From Fertilization to Adult Sexual Behavior
Excerpt:

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

My comment: See also this report on “m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs”
DNA’s dynamic nature makes it well-suited to serve as the blueprint of life
Excerpt:

“For something as fundamental as the double helix, it is amazing that we are discovering these basic properties so late in the game,” said Al-Hashimi. “We need to continue to zoom in to obtain a deeper understanding regarding these basic molecules of life.”

Excerpt:

“The team believes that RNA doesn’t form Hoogsteen base pairs because its double helical structure (known as A-form) is more compressed than DNA’s (B-form) structure. As a result, RNA can’t flip one base without hitting another, or without moving around atoms, which would tear apart the helix.” That means fixation of RNA-mediated amino acid substitutions is the basis of life and all biodiversity.

My comment: That fact means DNA cannot serve as the “blueprint of life” outside the context of biophysically constrained energy-dependent fixation of RNA-mediated amino acid substitutions that differentiate all cell types in all living genera. Science journalists continue to twist the facts to support the pseudoscientific nonsense of neo-Darwinian theories.
For musical fun with those who cannot link energy-dependent changes from angstroms to ecosystems in all living genera, see what intelligent people are doing with their experimental evidence of biologically-based cause and effect, which must start with changes in base pairs and link hydrogen-atom transfer from natural selection for energy-dependent codon usage to RNA-mediated amino acid substitutions in supercoiled DNA, which protects all organized genomes from virus-driven entropy.

To be continued.