Energy-dependent purifying selection / autophagy (5)

By: James V. Kohl | Published on: November 21, 2016

See: Energy-dependent purifying selection / autophagy (4)

See also: Team develops method to better identify genes involved in diseases

If we can pinpoint the genetic mutations that cause a particular disease, we can associate those mutations with specific proteins, and then design drugs to block or activate those proteins. We can also measure the activity of proteins identified in this manner to diagnose diseases more accurately, which is a major goal of precision medicine.

In: Histone Acetylome-wide Association Study of Autism Spectrum Disorder the same senior author admits this:

Acetylome aberrations in ASD were not attributable to genetic differentiation at cis-SNPs and highlighted genes involved in synaptic transmission, ion transport, epilepsy, behavioral abnormality, chemokinesis, histone deacetylation, and immunity.

That fact forced them to correlate energy-dependent epigenetically-effected histone acetylation with genotype and the discovery of what they refer to as >2,000 histone acetylation quantitative trait loci (haQTLs) in human brain regions, which include “…four candidate causal variants for psychiatric diseases.”  Their failure to discover any direct links from genes to behavior forced them to report their findings in the context of neo-Darwinian pseudoscientific nonsense instead of what is known about biophysically constrained energy-dependent biologically-based cause and effect.

They have been forced to report their findings in terms of epimutations and try to link mathematical models of QTLs to brain development in hopes that no one will notice that everything is epigenetically effected at the level of energy-dependent changes in cell type differentiation.

Old earth creationists and atheists have one thing in common. If they look at the experimental evidence of energy-dependent biologically-based cause and effect they are forced to put it into the context of their ridiculous theories. They must use definitions of meaningless terms like quantitative trait loci (QTL). QTLs are are energy-dependent changes that must be linked to ecological adaptation or they must be linked from virus-driven energy theft to all pathology.

 See: Energy-dependent purifying selection / autophagy (6 )

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