Trump’s appeal to common sense (2)
(click to enlarge)
See: Trump’s appeal to common sense
Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation
To our knowledge, this is the first study to use a genetic mouse model to simultaneously map Gpr182 localization patterns and elucidate novel physiological functions for the negative regulation of intestinal proliferative capacity, especially during regeneration and adenoma formation. Future studies to identify the ligand for this exciting and physiologically relevant orphan GPCR [G protein-coupled receptor] will shed light on its tractability as a potential therapeutic target.
Reported as: Unmasking previously misunderstood gene, scientists discover potential drug target for gastrointestinal cancers
The study also shows that science is as much about asking questions as finding answers.
The de novo creation of G protein-coupled receptors (GPCRs) and GPCR-mediated cell type differentiation is energy-dependent and RNA-mediated.
Nutrient energy-dependent microRNA flanking sequences link hydrogen-atom transfer in DNA base pairs in solution to all morphological and behavioral phenotypes via the de novo creation of GPCRs. See: The phylogenetic utility and functional constraint of microRNA flanking sequences
For example, the potential of hydrogen is expressed as pH and all biophysically constrained RNA-mediated energy-dependent protein folding chemistry is pH-dependent.
The questions that these researchers failed to ask are:
1) Where did the energy come from for the creation of this GPCR?
2) Where did the energy go when the GPCR mutated?
Until they understand the importance of the answers to those two questions, they will not know enough about GPCRs. It is important to link their creation from all energy-dependent chemotaxis and phototaxis to all biologically-based biodiversity on Earth via amino acid substitutions in supercoiled DNA, which protect all organized genomes from virus-driven energy theft and genomic entropy. Anyone who does not have enough common sense to link energy from ecological variation to ecological adaptation is not likely to learn that virus-driven energy theft causes all pathology via the loss of GPCRs.
See for comparison:
Family-wide structural characterization and genomic comparisons decode diversity-oriented biosynthesis of thalassospiramides by marine proteobacteria
…comparative genomics indicated that thalassospiramide production is likely to be attendant on particular genes/pathways for amino acid metabolism, signaling transduction and compound efflux.
Amino acid metabolism is nutrient energy-dependent.
See also: Perspectives on the history of evo-devo and the contemporary research landscape in the genomics era
The issue begins with articles about various aspects of genomics, with Holland et al. [26] discussing gene duplication and Urrutia and co-workers [51] alternative splicing and their contributions to phenotypic innovation while Orlando and co-workers [47] outline the latest methodologies that allow analysis of fossil genomes.
Alternative splicing is nutrient energy-dependent and it links RNA-mediated amino acid substitutions from the de novo creation of genes to the functional structures of all proteins and the morphological and behavioral phenotypes of all living genera via feedback loops that link what they eat to their physiology of pheromone-controlled reproduction.
Stability of the hybrid epithelial/mesenchymal phenotype
…we propose three particular network topologies that can be used to mine for other similar ‘phenotypic stability factors’ (PSFs) – (a) a double negative feedback loop with ZEB, (b) inhibition on both miR-200 and ZEB, and (c) a double negative feedback loop with ZEB as well as inhibiting miR-200. In all these three cases, the PSF can self-regulate positively or negatively. With a surging interest in mapping and modeling the signaling pathways regulating metastasis [45, 63, 101–104], the theoretical approach presented here can serve as a template to elucidate the effect of many intracellular and extracellular signals in regulating EMT dynamics and governing the relative stability of the E, M and E/M phenotypes.
Viruses send chemical messages
Virus-driven energy theft allows the metabolism of energy in viruses to be linked from viral microRNAs to all pathology. It does not allow anyone to link viruses to the evolution of heterosexual love.
Researcher investigates the science behind love
Larry Young already did this and decided that viruses must cause the evolution of human love.
https://www.youtube.com/watch?v=3Ms04x6MvMY
How Trump Could Unravel Obama’s Science Legacy
Funding science involves a delicate balance. Science in the Obama years tilted the needle towards applied research—from the launch of the ambitious Precision Medicine Initiative to sequence the genomes of one million people, to the creation of a string of institutes to foster robotics and other innovative manufacturing technologies in partnership with private industry.
The Precision Medicine Initiative preceded the National Microbiome Initiative. Pseudoscientists finally realized that energy-dependent metabolic networks must be linked to genetic networks in attempts to understand the difference between healthy longevity and the pathology, which is caused by virus-driven energy theft. For comparison, “…the creation of a string of institutes to foster robotics and other innovative manufacturing technologies in partnership with private industry” was a way to provide corporations with more taxpayer funded research as the amount of suffering from disease increased and the death toll continued to rise.
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Polycombic ecological adaptation as a science, not a theory (2)
12 MIN READ
0
Demoncrats fight polycombic ecological adaptation
4 MIN READ
0
Polycombic ecological adaptation as a science, not a theory
3 MIN READ
0
Biological evolution as a philosophy, not a science
6 MIN READ
0
Attacking Young Earth Creationists
5 MIN READ
0
80 years of causal analysis (1936 – 2016)
11 MIN READ
0
Did evolution autophosphorylate your kinases? (3)
2 MIN READ
1
The human virome (revisited)
4 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Hecatombic evolution VS polycombic ecological adaptation
3 MIN READ
0
Virus-mediated hecatombic evolution
2 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Did evolution autophosphorylate your kinases? (2)
5 MIN READ
1
Did evolution autophosphorylate your kinases?
5 MIN READ
1
Nutrient-dependent autophagy
3 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy (2)
6 MIN READ
0
The last RNA-mediated theory killer (2)
7 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy
3 MIN READ
0
Life is energy-dependent task management (4)
2 MIN READ
0
Life is energy-dependent task management (2)
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
0
Hypothesis free pseudoscience vs facts (4)
5 MIN READ
0
Hypothesis free pseudoscience vs facts (3)
3 MIN READ
0
Hypothesis free pseudoscience vs facts (2)
5 MIN READ
0
Hypothesis free pseudoscience vs facts (1)
5 MIN READ
0
Base pairs, olfaction and RNA thermometers
4 MIN READ
0
Chromatin: The structure of DNA (2)
8 MIN READ
0
Chromatin: The structure of DNA (3)
4 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
DNA repair via junk DNA (2)
5 MIN READ
0
The Aquatic Ape / Waterside Ape divergence
6 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
Displays of ecological adaptation (2)
3 MIN READ
0
DNA repair via junk DNA (1)
5 MIN READ
0
Displays of ecological adaptation
2 MIN READ
0
Unconstrained mutations, Zika virus, Kallmann’s syndrome
4 MIN READ
0
Virus-driven energy theft causes cancer
2 MIN READ
0
Linking RNA structure to function
3 MIN READ
0
Exosomes, Inflammatory Disease, Pathogenesis, Treatment
< 1 MIN READ
0
How did the innate immune system evolve?
4 MIN READ
0
The Aquatic Ape: New evidence?
4 MIN READ
0
Plant microRNAs slow virus-driven aging
3 MIN READ
0
Protecting 4 billion people from virus-driven entropy
< 1 MIN READ
0
Increased soil pH and nutrient availability
4 MIN READ
0
Energy-dependent cellular communication
3 MIN READ
0
Lawless evolution: No physics
4 MIN READ
0
Conserved biophotonic emissions
7 MIN READ
2
Antithetical conclusions (7)
3 MIN READ
0
Antithetical conclusions (5)
4 MIN READ
0
Antithetical conclusions (6)
3 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
Anthetical conclusions (2)
5 MIN READ
0
Non-random pheromone-controlled cell type differentiation
3 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
Co-evolution and co-speciation replace neo-Darwinian nonsense
4 MIN READ
0
Energy-dependent natural fluorescence and bioluminescence
2 MIN READ
0
Pseudoscientists ignore what serious scientists prove
6 MIN READ
0
Food supplement or licensed immunostimulant?
6 MIN READ
0
Virus-driven downsizing of the human brain (3)
4 MIN READ
0
Do weak bosons evolve into leptons?
4 MIN READ
0
Q and A: Energy-dependent cell type differentiation
10 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity (2)
19 MIN READ
0
The end of neo-Darwinism
5 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
0
The Origin of Information (2)
6 MIN READ
0
The tipping point? 50,000 publications (5)
3 MIN READ
0
Did “Nature” kill Steve Jobs? (3)
10 MIN READ
0
Invisible dark matter
< 1 MIN READ
0
Funding the Human Genome Project-Write
2 MIN READ
0
Did “Nature” kill Steve Jobs?
3 MIN READ
0
Virus-driven downsizing of the human brain (2)
< 1 MIN READ
0
RNA methylation (revisited)
< 1 MIN READ
0
Placing boundaries where none exist
< 1 MIN READ
0
Virus-driven downsizing of the human brain
2 MIN READ
0
MicroRNAs and sexual orientation
8 MIN READ
0
RNA methylation, learning, memory and behavior,
< 1 MIN READ
0
Innate immunity and multiplexing
7 MIN READ
0
Amino acids and virus penetration
3 MIN READ
0
Major transition ends use of silly theories
5 MIN READ
0
RNA methylation
2 MIN READ
0
Model vs theory: Progress report!
8 MIN READ
0
Masters of deception about nature (2)
7 MIN READ
0
Masters of deception about nature
8 MIN READ
0
The Mind’s Eyes (revisited)
10 MIN READ
0
Cracking the Olfactory Code?
5 MIN READ
0
RNA methylation, behavior, and disease
6 MIN READ
0
Modelling life scientifically: RNA-mediated events
12 MIN READ
0
Energy-dependent RNA methylation (9)
2 MIN READ
0
Energy-dependent RNA methylation (10)
4 MIN READ
0
Energy-dependent RNA methylation (8)
4 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (5)
3 MIN READ
0
Energy-dependent RNA methylation (4)
5 MIN READ
0
Energy-dependent RNA methylation (3)
10 MIN READ
0
Energy-dependent RNA methylation (2)
5 MIN READ
0
Energy-dependent RNA methylation (1)
6 MIN READ
0
Secular humanism and ecoterrorism
4 MIN READ
0
Thermotolerance and longevity (2)
3 MIN READ
0
War Games: False Flag Terrorism (2)
4 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
0
Virus-driven energy theft: definition?
5 MIN READ
0
Energy-dependent biodiversity (4)
4 MIN READ
0
The tipping point? 50,000 publications (4)
3 MIN READ
0
Energy-dependent biodiversity (3)
7 MIN READ
0
Energy-dependent biodiversity (2)
2 MIN READ
0
Energy-dependent biodiversity
5 MIN READ
0
The tipping point? 50,000 publications (3)
6 MIN READ
0
The tipping point? 50, 000 publications
4 MIN READ
0
Neo-Darwinism failed in 1995
3 MIN READ
0
Countdown to Genetics and Genomics
< 1 MIN READ
0
Magic, Miracle, or Molecular Mechanism (2)
8 MIN READ
0
Energy-dependent creation and entropy
4 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics
9 MIN READ
0
Wasted Templeton Funding (4)
3 MIN READ
0
MicroRNAs and/or QTLs: Who buried what?
2 MIN READ
0
From nothing to life and death everywhere
5 MIN READ
0
Molecular Diagnostics: What is unprotected life? (5)
5 MIN READ
0
Molecular Diagnostics: What is unprotected life (4)
2 MIN READ
0
Molecular Diagnostics: What is unprotected life (3)
5 MIN READ
0
Molecular Diagnostics: What is unprotected life? (2)
7 MIN READ
0
Molecular Diagnostics: What is unprotected life?
2 MIN READ
0
Virus-driven sex differences?
2 MIN READ
0
Ricki Lewis’ Time Machine (4)
8 MIN READ
0
Half truths support theories without facts
4 MIN READ
0
YEC compared to Perry Marshall’s opinions
4 MIN READ
0
Ricki Lewis’ Time Machine (3)
5 MIN READ
0
Creating nutrient-dependent life with enough genes to survive
3 MIN READ
0
Ignore the evidence: Rachel Feltman
5 MIN READ
0
Virus-driven disorder prevention and health promotion
6 MIN READ
0
Stress-linked population-level history dependence
5 MIN READ
0
Jay R. Feierman: twenty years of antagonism
5 MIN READ
0
Energy dependent RNA-mediated immunity (6)
5 MIN READ
0
Do not miss the misrepresentations
2 MIN READ
0
Energy dependent RNA-mediated immunity (3)
8 MIN READ
0
Energy dependent RNA-mediated immunity (2)
10 MIN READ
0
RNA-mediated DNA modifications
5 MIN READ
0
Science vs semantics
4 MIN READ
0
From angstroms to ecosystems and entropy
2 MIN READ
0
Bacteria see the light and they adapt (2)
5 MIN READ
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands (2)
3 MIN READ
0
Bringing RNA back to epigenetics (20 years later)
11 MIN READ
0
Hybrids: making microbes and Democrats into monkey’s uncles?
11 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (7)
5 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
The Light and Darkness of “Evolution 2.0”
11 MIN READ
0
Organic Compounds and the Miracle of Smell and Taste
7 MIN READ
0
Ricki Lewis’ Time Machine (2)
6 MIN READ
0
Ricki Lewis’ Time Machine
5 MIN READ
0
Virus-perturbed alternative splicings
3 MIN READ
0
Cytogenetic approaches link biosystems to ecosystems
3 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (5)
10 MIN READ
0
The radical pair mechanism of ecological speciation
3 MIN READ
0
Origin and evolution of the genetic code
2 MIN READ
0
Blood test links atoms to ecosystems
2 MIN READ
0
Another failed rescue attempt
5 MIN READ
0
Juvenile hormone links atoms to ecosystems
3 MIN READ
0
Ecological genomics: teleophobes respond (too late)
10 MIN READ
0
Genes, orchid odors, and pheromones from blonds
5 MIN READ
0
Amino acid substitutions, stress, and human behavior
3 MIN READ
0
RNA-mediated theory killers (11) (12) (13) (14) (15)
7 MIN READ
0
MicroRNA-mediated RNA epigenetics
2 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Epigenetic (re)programming of behavior (3)
5 MIN READ
0
Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
0
Assumptions prove ignorance
5 MIN READ
0
Neo-Darwinian sink testing
2 MIN READ
0
NORAD: air defense and defense against genomic entropy
7 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
RNA-mediated theory killers (5)
2 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
RNA-mediated theory killers
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
RNA-mediated everything
4 MIN READ
0
The Sherlock lab: Beneficial mutations
5 MIN READ
0
Neo-Darwinism vs the neocortex
4 MIN READ
0
Plasma created by sunlight and RNA–mediated epigenetic heredity
2 MIN READ
0
Positive feedback loops and epigenetic traps
2 MIN READ
0
Stress-perturbed mitochondrial dysfunction (2)
5 MIN READ
0
Stress-perturbed mitochondrial dysfunction
4 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
Neuroplasticity
4 MIN READ
0
Sensationalizing no new mechanism
2 MIN READ
0
Cell type differentiation: atoms to ecosystems
2 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
From dust to genomic entropy?
3 MIN READ
0
Virus, transposon and plasmid evolution
< 1 MIN READ
0
Can veterans and other prisoners escape pseudoscience?
2 MIN READ
0
eQTLs and ecological adaptation
< 1 MIN READ
0
Ecological speciation. Get it, theorists?
< 1 MIN READ
0
Human pheromone deniers: What’s next?
5 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
0
Xist-ing on planet Earth
2 MIN READ
0
Cancer: forward and reverse
2 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
The creation and activation of GPCRs
4 MIN READ
0
Multi-omic analysis features (SNPs, miRNA)
3 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
New anti-entropic microbes
3 MIN READ
0
RNA-mediated permanent symbioses
11 MIN READ
0
Atomic-resolution of cell type signaling
4 MIN READ
0
Unraveling evolutionary pseudoscience
2 MIN READ
0
Olfaction & the octopus and human genomes (2)
4 MIN READ
0
Protosuns, prebiotic molecules, proteins, and people
4 MIN READ
0
Viruses, amino acids, and somatic cell types
4 MIN READ
0
RNA-mediated morphological AND behavioral phenotypes
2 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
RNA-mediated cell type differentiation: Honeybee
< 1 MIN READ
0
RNA-mediated development
2 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
Healthy mutants
2 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Bees and primates automagically evolve
3 MIN READ
0
Five years of Ferguson
2 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
Viruses in gut microbes
4 MIN READ
0
MicroRNAs and the exposome
5 MIN READ
0
Epigenetics vs the fossil record
4 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Pathology constrains X-linked evolution
2 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Life: conserved ion and amino acid transporters
3 MIN READ
0
MicroRNAs and memory
< 1 MIN READ
0
Methylation maintains cell type differences
3 MIN READ
0
Creating nothing but a theory (2)
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
Correctly modeling biological energy
2 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
RNA-directed gene choice
5 MIN READ
0
What about birds?
5 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
Imagining that data historically supports evolutionary theory
7 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease (2)
3 MIN READ
0
RNA-mediated epigenetic modification via DNA-methylation
4 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
All of "like kind" in the (bigger) family
6 MIN READ
1
Environment epigenetically shapes the immune system
3 MIN READ
0
Beneficial microbes kill beneficial mutations
4 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
Unified nutritional and molecular mechanisms
9 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
Model organisms: the birds and the bees
3 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
One test of bioenergetic health?
2 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
RNA-mediated species specificity
2 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
Sexual differentiation of cell types in plants
2 MIN READ
0
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
No understanding of biodiversity
2 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
How much good can be attributed to social science theories?
< 1 MIN READ
0
RNA-mediated events are not a matter of faith
2 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Epigenetically-effected metabolic shifts and ecological adaptations
3 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
Probable changes in connectivity
2 MIN READ
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
The new light of chromosomal rearrangements
3 MIN READ
0
The wrong picture of our evolution
4 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
[…] See also: Trump’s appeal to common sense (2) […]