Dobzhansky 1973 and precision medicine (4)

By: James V. Kohl | Published on: January 25, 2017

See: Dobzhansky 1973 and precision medicine (3)
Evidence-based medicine has been hijacked: a report to David Sackett
Fake news

See for comparison: Sugar Gliders, Flying Squirrels, and How Evolutionists Explain Away Uncooperative Data

…contradictory evidence drives evolutionists to embrace irrational just-so stories. Natural selection cannot “adapt” anything. Natural selection kills off the bad designs. It cannot influence the random mutations that must, somehow, come up with such amazing designs. This is the hard reality, but in order to rationalize the evidence, evolutionists must resort to this sort of teleological language, personifying and endowing natural selection with impossible powers. As often happens, a distinctive grammatical form — “for similar lifestyles” — is a dead giveaway. Natural selection becomes a designer.

Creationists shoot themselves in the foot each time they fail to mention the fact that natural selection for energy-dependent codon optimality is obviously the link from the sun’s anti-entropic virucidal energy to ecological adaptations manifested in all biodiversity. See:
Most of the proponents of Intelligent Design still seem to be fighting against the concept of energy as information. Some of them seem to hate the fact that virus-driven energy theft has been linked to all pathology. I suspect their hatred is inspired by their ignorance. They never learned that sunlight is the anti-entropic energy source for all life on Earth.

If energy is not equal to information, where does the life sustaining information come from that links physics and chemistry to molecular epigenetics? And where does the energy go after death or after the extinction of a species?
See also: Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

One way to influence extracellular metabolites is through active modification or degradation by other organisms (7–9).

…this reaction is reminiscent of reduced flavin acting as the electron donor in its own destruction in vitamin B12 biosynthesis (30).

There should be no need to link vitamin B12 biosynthesis or any other biosynthetic process to biodiversity since all protein biosynthesis and degradation is energy-dependent and biophysically constrained by RNA-mediated protein folding chemistry. Serious scientists have known for several decades how energy-dependent changes in chirality must be linked from sunlight to autophagy by nutrient-dependent pheromone-controlled quorum-sensing in species from microbes to humans. Every aspect of biophysically constrained protein folding chemistry in all cell types of all individuals of all living genera involves thermodynamic cycles of hydrogen-atom transfer in DNA base pairs in solution, which link ecological variation to ecological adaptation via protein biosynthesis and degradation.
The weekend resurrection of the bacterial flagellum in P. fluorescens links its nutrient-dependent pheromone-controlled physiology of reproduction to the  nutrient-dependent pheromone-controlled physiology of reproduction in P. aeruginosa,
See also: Neuroscience of Early-Life Learning in C. elegans Scientists identify the brain circuits with which newly hatched nematodes form and retrieve a lifelong aversive olfactory memory.
My comment:

See also:  Pan-neuronal imaging in roaming Caenorhabditis elegans
Reported as: Watching sensory information translate into behavior

“We have long been recording behavior in worms, but we and others have concluded that, if you want to get physiologically relevant neural activity patterns, you have to look at neurons inside a behaving animal,” Samuel explained. “Only in that context are all feedback loops intact, where behavioral output modulates neural activity which, in turn, shapes behavior.”

As all serious scientists continue to link ecological variation to ecological speciation via nutrient-dependent pheromone-controlled reproduction in species from microbes to humans, my antagonists have all but disappeared.

Clearly, it is time to finally begin discussion of how virus-driven energy theft links hydrogen-atom transfer in DNA base pairs in solution from mutations to pathology instead of from nutrient-dependent RNA-mediated DNA repair via amino acid substitutions to supercoiled DNA, which protects organized genomes from virus-driven entropy.

My comment to the Scientist led to a warning from senior editor Bob Grant.  I was told not to post anything else about virus-driven energy theft.
See Schrodinger (1944) for his prescient representation of what has since been exemplified in all organisms.

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

In the reprint edition, the facts about the extremely well-ordered state of matter in food were placed into the context of this question.

How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy? — Roger Penrose (8 August 1991)

See also: American Society for Biochemistry and Molecular Biology “This morning [1/24/16], ASBMB learned that an email went out today to senior NIH officials apparently instituting temporary procedures for correspondence with public officials. The email states that all correspondence must be approved by the Department of Health and Human Services. We contacted NIH to find out what’s going on.”
Here’s what we found: NIH transition – trying to provide clarity

Conclusion: …we, frankly, do not know if this is the beginning of a new phase of more restricted communications, or if everything will go back to normal – whatever that means – after Feb. 3.

We do know, however, that any effort to stop a scientific agency from responding to congressional, federal, state and local inquiries has a chilling effect.  As we told the Huffington Post, peer-reviewed science should remain free of politicization, and we support the NIH and all federally funded scientific agencies in their efforts to continue on their missions without political interference.

The fact that they told the Huffington Post anything makes the American Society for Biochemistry and Molecular Biology seem to be in bed with the Demoncrats. Political interference from liberals and theorists has cost billions of dollars that could have been spent on preventative medicine and to implement Precision Medicine based on what has been learned from the National Microbiome Initiative.
See also: The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters
They link short, recurring patterns in DNA, which pseudoscientists call sequence motifs to sequence-specific binding sites for proteins. nucleases, transcription factors (TF), and other proteins link energy-dependent RNA mediated ribosome binding, mRNA processing (splicing, editing, polyadenylation) and transcription termination. Serious scientists put the facts about RNA-mediated events into the context of natural selection for energy-dependent codon optimality and healthy longevity. Pseudoscientists fail to link virus-driven energy theft to all pathology because they don’t know enough about physics, chemistry, and molecular epigenetics to integrate the experimental evidence. If they could do that, they would have a model of biophysically constrained biologically-based cause and effect. Instead, they have reputations to protect.
Reported as:Biologists unlock code regulating most human genes

They also discovered that this sequence is located precisely at the start site of more than half of all , underlining the importance of the human Initiator in the human genome.

The human Initiator in the human genome is of no importance whatsoever unless it can be linked from natural selection for energy-dependent codon optimality to healthy longevity, and from virus-driven energy theft to all pathology.
See: Dobzhansky 1973 and precision medicine (5)

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