ATP-dependent creation of RNA
(click to enlarge)
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing
They suggest that deep evolution somehow conserved energy-dependent phosphorylation sites. The sites somehow link changes in the microRNA/messenger RNA balance from RNA-mediated cell type differentiation to morphological and behavioral diversity via amino acid substitutions in supercoiled DNA. But they do not mention chirality, autophagy, or supercoiled DNA in the context of molecular mechanisms that optimize microRNA activity in diverse species.
Reported on January 25, 2017 as: Partnering MicroRNAs & Targets in a Molecular Dance
The authors of the article and the science journalist fail to link an energy source to the molecular dance and they fail to link virus-driven energy theft to the end of the biophysically constrained dance.
My summary: Their failure to link changes in the speed of light on contact with water from chirality to energy-dependent RNA-mediated autophagy and biophysically constrained cell type differentiation exemplifies the failure of Precision Medicine to link nutrient energy-dependent endogenous RNA interference (RNAi) to healthy longevity and all biodiversity via metabolic networks and genetic networks to the physiology of reproduction.
Instead, the fact that RNAi targets exogenous genes in models of viral infection has been touted in the context of a “A Billion Dollar Baby in Therapy.” See: Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy
See for comparison: Fire A (1999) RNA-triggered gene silencing .
Facts about ATP and the energy-dependent creation of RNA, which is required for gene silencing, seems to be missing from every aspect of energy-dependent gene activation and biophysically constrained RNA-mediated protein folding chemistry. See: DEPENDENCE OF RNA SYNTHESIS IN ISOLATED THYMUS NUCLEI ON GLYCOLYSIS, OXIDATIVE CARBOHYDRATE CATABOLISM AND A TYPE OF “OXIDATIVE PHOSPHORYLATION” (1964)
Fifty-two years later we have this representation of what is known
VIDEO
That representation can be compared to what is known about endogenous RNA interference and cell type differentiation in the context of virus-driven energy theft and all pathology.
VIDEO
See also: Bistability, Stochasticity, and Oscillations in the Mitogen-Activated Protein Kinase Cascade
Our stochastic modeling reveals that small changes in protein abundances can have large effects on MAPK activation. Additionally, data on protein turnover suggests that protein degradation plays an important role in regulating the pheromone pathway. Pheromone-stimulated degradation has been documented previously for the receptor (Ste2) (8), a regulator of G-protein signaling (Sst2) (9), components of the effector kinase cascade (Ste11, Ste7) 9., 10. and 11., and the transcription factor (Ste12) (12).
Bistability, Stochasticity, and Oscillations have been linked from femtosecond blasts of virucidal UV light to RNA-mediated DNA repair and cell type differentiation that links feedback loops from odors and pheromones to the physiology of reproduction in all living genera. That’s why all serious scientists are Combating Evolution to Fight Disease. That fact makes it difficult for me to accept any more claims about deep evolution.
See also: microRNA “amino acid”
For example: Essential amino acid ratios and mTOR affect lipogenic gene networks and miRNA expression in bovine mammary epithelial cells.
For example: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition.
Given the ease of finding supporting evidence that links nutrient-energy-dependent endogenous RNA interference to all cell type differentiation via natural selection for energy-dependent codon optimality and the physiology of reproduction, I wonder why Mendell’s group still touts “deep evolution” in the context of energy-dependent phosphorylation.
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4 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
A working model of “captured” genes
6 MIN READ
0
DNA repair via junk DNA (2)
5 MIN READ
0
The Aquatic Ape / Waterside Ape divergence
6 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
Unconstrained mutations, Zika virus, Kallmann’s syndrome
4 MIN READ
0
How did the innate immune system evolve?
4 MIN READ
0
Protecting 4 billion people from virus-driven entropy
< 1 MIN READ
0
Increased soil pH and nutrient availability
4 MIN READ
0
Energy-dependent cellular communication
3 MIN READ
0
Lawless evolution: No physics
4 MIN READ
0
Conserved biophotonic emissions
7 MIN READ
2
Antithetical conclusions (7)
3 MIN READ
0
Antithetical conclusions (5)
4 MIN READ
0
Antithetical conclusions (6)
3 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
Co-evolution and co-speciation replace neo-Darwinian nonsense
4 MIN READ
0
Virus-driven downsizing of the human brain (3)
4 MIN READ
0
Do weak bosons evolve into leptons?
4 MIN READ
0
Q and A: Energy-dependent cell type differentiation
10 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity (2)
19 MIN READ
0
The end of neo-Darwinism
5 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
0
Did “Nature” kill Steve Jobs? (3)
10 MIN READ
0
Funding the Human Genome Project-Write
2 MIN READ
0
Did “Nature” kill Steve Jobs?
3 MIN READ
0
Virus-driven downsizing of the human brain (2)
< 1 MIN READ
0
RNA methylation (revisited)
< 1 MIN READ
0
Placing boundaries where none exist
< 1 MIN READ
0
Virus-driven downsizing of the human brain
2 MIN READ
0
MicroRNAs and sexual orientation
8 MIN READ
0
RNA methylation, learning, memory and behavior,
< 1 MIN READ
0
Innate immunity and multiplexing
7 MIN READ
0
Amino acids and virus penetration
3 MIN READ
0
Major transition ends use of silly theories
5 MIN READ
0
Model vs theory: Progress report!
8 MIN READ
0
Masters of deception about nature (2)
7 MIN READ
0
Masters of deception about nature
8 MIN READ
0
The Mind’s Eyes (revisited)
10 MIN READ
0
Cracking the Olfactory Code?
5 MIN READ
0
RNA methylation, behavior, and disease
6 MIN READ
0
Modelling life scientifically: RNA-mediated events
12 MIN READ
0
Energy-dependent RNA methylation (9)
2 MIN READ
0
Energy-dependent RNA methylation (10)
4 MIN READ
0
Energy-dependent RNA methylation (8)
4 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (4)
5 MIN READ
0
Energy-dependent RNA methylation (3)
10 MIN READ
0
Energy-dependent RNA methylation (2)
5 MIN READ
0
Energy-dependent RNA methylation (1)
6 MIN READ
0
Secular humanism and ecoterrorism
4 MIN READ
0
Thermotolerance and longevity (2)
3 MIN READ
0
War Games: False Flag Terrorism (2)
4 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
0
Virus-driven energy theft: definition?
5 MIN READ
0
Energy-dependent biodiversity (4)
4 MIN READ
0
The tipping point? 50,000 publications (4)
3 MIN READ
0
Energy-dependent biodiversity (2)
2 MIN READ
0
Neo-Darwinism failed in 1995
3 MIN READ
0
Countdown to Genetics and Genomics
< 1 MIN READ
0
Magic, Miracle, or Molecular Mechanism (2)
8 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics
9 MIN READ
0
Wasted Templeton Funding (4)
3 MIN READ
0
RNA splicing, genetic variation, and disease
2 MIN READ
0
From nothing to life and death everywhere
5 MIN READ
0
Magic, Miracle, or Molecular Mechanism?
10 MIN READ
0
Molecular Diagnostics: What is unprotected life (4)
2 MIN READ
0
Virus-driven sex differences?
2 MIN READ
0
Ricki Lewis’ Time Machine (4)
8 MIN READ
0
Creating and/or programming the immune system
< 1 MIN READ
0
Half truths support theories without facts
4 MIN READ
0
Ignore the evidence: Rachel Feltman
5 MIN READ
0
Jay R. Feierman: twenty years of antagonism
5 MIN READ
0
Energy dependent RNA-mediated immunity (4)
6 MIN READ
0
Bacteria see the light and they adapt (2)
5 MIN READ
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA (2)
9 MIN READ
0
Despicable fools?
4 MIN READ
0
Ricki Lewis’ Time Machine
5 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (5)
10 MIN READ
0
The radical pair mechanism of ecological speciation
3 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (4)
4 MIN READ
0
Teleophobes vs teleophiles: a recent history
2 MIN READ
0
Ecological genomics: teleophobes respond (too late)
10 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
0
Ecological adaptations you cannot live without
6 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
0
Stress-perturbed mitochondrial dysfunction (2)
5 MIN READ
0
Too complex for the Complex Biological Systems Alliance
4 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Neo-Darwinian logic is nonsense
3 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
New anti-entropic microbes
3 MIN READ
0
Natural selection: an anti-entropic force?
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Is SUMOylation RNA-directed DNA methylation?
2 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
0
Imagining that data historically supports evolutionary theory
7 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
0
Removing natural selection; reshaping the horse; adjusting evolutionary theory
4 MIN READ
0
Single-cell level assay of protein biosynthesis and degradation
2 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Ecological adaptations reported as evolution in insects and mammals
4 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
ALPHA GENOMIX
7 MIN READ
2
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
Evolutionary theorists and evolutionary theists live under rocks
< 1 MIN READ
0
RNA-mediated events are not a matter of faith
2 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Do bacterial proteins evolve?
3 MIN READ
0
Probable changes in connectivity
2 MIN READ
0
Memory of repression and memory of behavior (2)
< 1 MIN READ
0
Nutrient-dependent pheromone-controlled exercise-induced physiques
< 1 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Is the problem an internet echo or Feierman's ethics?
2 MIN READ
0
Mechanisms that are not understood increase clarity
4 MIN READ
2
Evolutionary heritage or ecological adaptation? Racism versus reality
4 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0
Targeting a cancer gene
2 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
0
Natural selection and the behavior of whole organisms
< 1 MIN READ
0
Natural selection: New insights are unlikely
< 1 MIN READ
0
Human pheromones and IQ via neurogenic and socio-cognitive niche construction
2 MIN READ
0
Human pheromones, nutrition, DNA, epigenetics
2 MIN READ
0