Energy as information and constrained endogenous RNA interference (2)

By: James V. Kohl | Published on: February 4, 2017

Precision Medicine virtual conference, Feburary 22-23, 2017
This abstract has been accepted for presentation as a poster.
Title: Energy as information and constrained endogenous RNA interference

  •  James V. Kohl
  • Abstract describing the poster

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry.  Light induced energy-dependent changes link  angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.
The National Microbiome Initiative links microbial quorum sensing  to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.
This detailed representation of energy-dependent natural selection for codon optimality links  biologically- based cause and effect from G protein-coupled receptors to  RNA-mediated amino acid substitutions and the functional structure of  supercoiled DNA.  Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.
For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from  archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.
See also: Catalyst mediates energy-efficient proton transport for reversibility

Scientists at Pacific Northwest National Laboratory built a catalyst that mimics nature’s hydrogen-splitting enzymes—working reversibly at room temperature and pressure without added energy. This was achieved by stabilizing the catalyst’s structure by attaching an amino acid…”

This means they could also link the sun’s anti-entropic virucidal energy from the speed of light on contact with water to chirality and autophagy, which link the physiology of reproduction from supercoiled DNA to all biodiversity via hydrogen atom transfer in DNA base pairs in solution and endogenous RNA interference.
The mysterious 98%: Scientists look to shine light on the ‘dark genome’

 …hidden among this noncoding DNA are many crucial regulatory elements that control the activity of thousands of genes. What is more, these elements play a major role in diseases such as cancer, heart disease, and autism, and they could hold the key to possible cures.”
Nothing is hidden. Everything has been revealed in the context of what is known to all serious scientists about biophysically constrained endogenous RNA interference.

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